Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches

Specialized fibroblastic reticular cell (FRC) subsets in lymph nodes orchestrate the compartmentalization that guides immune cell migration, interaction, and function. Alouche et al. examine the signa...

cell.com

Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells

Mitochondrial complex I dysfunction in dendritic cells disrupts NAD+/NADH redox balance and impairs antigen cross-presentation.

science.org

Coupling dead cell recognition to Fcγ receptors augments anticancer immunity - Nature Cancer

Castro-Dopico et al. report the design of reagents to bridge F-actin and Fcγ receptors, endowing a range of antigen-presenting cells with the ability to cross-present antigens from dead tumor cells an...

nature.com

Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit

The efficacy of immune checkpoint inhibitors (ICIs) in colon cancer (CC) is limited by the tolerogenic immune landscape of both the tumor and the inte…

sciencedirect.com

Pan-cancer single-cell atlases of mouse and human tumor-associated dendritic cells - Nature Communications

Multiple lineages and functional states of tumor-associated dendritic cells (TADCs), as essential inducers of anti-tumor immunity, have been reported. Here, the authors have generated single-cell RNA ...

nature.com

Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications

Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...

nature.com

Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches

Specialized fibroblastic reticular cell (FRC) subsets in lymph nodes orchestrate the compartmentalization that guides immune cell migration, interaction, and function. Alouche et al. examine the signals governing FRC differentiation and identify a Notch2-dependent process by which homeostatic mature dendritic cells drive Ccl19hi T-zone fibroblast differentiation, maintain segregation of distinct T-zone niches, and support CD8+ T cell memory formation.

dlvr.it

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells

Chromatin-organizing cohesin complex cooperates with transcription factor IRF8 to enable the functionality of dendritic cells in vivo.

science.org

Transcription factor Etv3 controls the tolerogenic function of dendritic cells

Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-de...

science.org

TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs - Nature Immunology

Recent work has revealed that dendritic cells (DCs) are more heterogeneous than previously thought, yet the functional roles of these newly described DC subsets remain unclear. Here, Li et al. find th...

nature.com

The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types - Nature Immunology

Dendritic cells (DCs) are required to establish thymic central tolerance. Here Srinivasan et al. use single-cell transcriptomics to define thymic conventional dendritic cell (cDC) subsets and find tha...

nature.com

Claudin 1–mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance | Journal of Experimental Medicine | Rockefeller University Press

Březina et al. demonstrate that Claudin 1 enables thymic type 1 dendritic cells to localize within proximity to medullary thymic epithelial cells. This spa

rupress.org

DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function

Carboplatin reshapes macrophages to protect the heart through type I IFN signaling in mouse models.

scim.ag

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology

Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

nature.com

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology

Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

nature.com

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells - Nature Immunology

Pucella, Maqueda-Alfaro and colleagues distinguish three developmentally related subsets of mouse plasmacytoid dendritic cells that differ in their ability to produce type I interferon and their susce...

nature.com

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections - Nature Immunology

Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.

nature.com