Bartomeu Colom
@bartomeucolom.bsky.social
Senior Scientist @altoslabs, previously @sangerinstitute.bsky.social. Stem cells, somatic mutations & cell competition in aging and early cancer. Views are my own. https://scholar.google.com/citations?hl=en&user=o5vRhIAAAAAJ
🚨 New paper from our lab just published in Nature🚨 www.nature.com/articles/s41... Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone ✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social
Thanks for featuring our work on how emerging tumour remodel their nascent niche 🌱promoting their survival @cam.ac.uk, @scicambridge.bsky.social , @cruk-ci.bsky.social, @pdncambridge.bsky.social www.stemcells.cam.ac.uk/news/alcolea... www.nature.com/articles/s41...
'Mechanisms of cellular fitness and cell competition: Towards an integrated view' www.sciencedirect.com/science/arti...
'Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer' www.nature.com/articles/s41...
'Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength' www.nature.com/articles/s43...
Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength - Nature Aging
With aging, somatic mutations accumulate in cellular DNA; however, whether they drive age-related functional decline is incompletely understood. Here the authors show that these mutations can weaken m...
nature.com
'Geographic and age variations in mutational processes in colorectal cancer' www.nature.com/articles/s41...
'Emergence and properties of adult mammalian epidermal stem cells' www.sciencedirect.com/science/arti...
'Clonal driver neoantigen loss under EGFR TKI and immune selection pressures' www.nature.com/articles/s41...
Hundsdorfer, L., Muenkel, M., Aparicio-Yuste, R., ..., Mostowy, S., & Bastounis, E. E. (2025). ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells. Cell reports, 44(1), 115193. #EpithelialMechanics buff.ly/g0GPOtr
🛫You won’t want to miss us in stunning Malta!🌴🏖️ Get ready to be inspired at the STEM CELLS & CANCER conference. INCREDIBLE LINE-UP of speakers! 🎙️Cedric Blanpain @cedric-blanpain.bsky.social 🎙️Peter Dirks 🎙️Catriona Jamieson… and more 🧵 📅 September 28, 2025 🔗 bit.ly/49sCfJp @fusionconf.bsky.social
Maria Alcolea@mariapalcolea.bsky.social · 2y ago✈️Join us in paradise! The stunning Malta will be the perfect setting to stimulate great discussions on Stem Cell and Cancer Biology 🔬 World-leading experts will share their exciting science. 🗓️Fusion Conference Stem Cells & Cancer! September 28, 2025 bit.ly/49sCfJp
'Translating premalignant biology to accelerate non-small-cell lung cancer interception' www.nature.com/articles/s41...
Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork! Free link: rdcu.be/eeeA2 www.nature.com/articles/s41...
Matrix-producing neutrophils populate and shield the skin
Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...
rdcu.be
'Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis' www.cell.com/cancer-cell/...
'The complex interplay between aging and cancer' www.nature.com/articles/s43...
The complex interplay between aging and cancer - Nature Aging
This Review explores the intersection between cancer and aging, illustrating shared causal mechanisms including genome instability, telomere dysfunction, cellular senescence and dysregulated immunity ...
nature.com
'Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation' www.sciencedirect.com/science/arti...
So happy to share the newest pre-print from the lab where we show that old age significantly changes the traits that evolve in established lung adenocarcinoma. This work sheds light into the importance of modeling age-related cancers in the context of old age. www.biorxiv.org/content/10.1...
Aging directs the differential evolution of KRAS-driven lung adenocarcinoma
Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer( [1][1], [2][2] ), is a disease of the elderly, with an average age of diagnosis of about 70 years of age( [3][3] ). Old...
biorxiv.org
Our first 2025 paper! We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer. Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏 www.nature.com/articles/s41...
Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology
Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...
nature.com
✈️Join us in paradise! The stunning Malta will be the perfect setting to stimulate great discussions on Stem Cell and Cancer Biology 🔬 World-leading experts will share their exciting science. 🗓️Fusion Conference Stem Cells & Cancer! September 28, 2025 bit.ly/49sCfJp
A nice article covering some of the surprises in the field of somatic mosaicism in the last decade. As I say there: "Judging by the discoveries that we are making at the moment, the journey has only just started. I expect many surprises in the next few years." knowablemagazine.org/content/arti...
We are all mosaics
Picture your body: It’s a collection of cells carrying thousands of genetic mistakes accrued over a lifetime — many harmless, some bad, and at least a few that may be good for you.
knowablemagazine.org
'Spatial transcriptomic clocks reveal cell proximity effects in brain ageing' www.nature.com/articles/s41...
'iFlpMosaics enable the multispectral barcoding and high-throughput comparative analysis of mutant and wild-type cells' www.nature.com/articles/s41...
