🧵 How did chickens become the world's biggest source of Campylobacter? Changes in agriculture have transformed chickens into the world's largest reservoir of one of our most common bacterial pathogens. Here's the story... 👇 #MicroSky #OneHealth
Ben Pascoe
@benizao.bsky.social
Senior Research Fellow at the University of Oxford using genomics to investigate the global spread and evolution of bacterial pathogens. Science | Sport | Music
🧵 GETCampy Stories #3 Campylobacter is the leading cause of bacterial gastroenteritis worldwide. Yet we still don't have a licensed human vaccine, and reducing infections remains surprisingly difficult. Why? 👇 #MicroSky #OneHealth #Campylobacter
Insertion sequence elements associated with Staphylococcus epidermidis evolution in persistent orthopaedic device-related infections
Insertion sequence elements associated with Staphylococcus epidermidis evolution in persistent orthopaedic device-related infections - PubMed
Our findings highlight the prominent role of IS elements in driving genetic diversification in S. epidermidis, underscoring the need for closer examination of their contribution to pathoadaptation during...
t.co
Genomic insights into specialized and primary metabolism gene clusters in methicillin-resistant Staphylococcus aureus from Egyptian community settings
Genomic insights into specialized and primary metabolism gene clusters in methicillin-resistant Staphylococcus aureus from Egyptian community settings - PubMed
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) remains a major public health concern. Beyond canonical virulence determinants, biosynthetic gene clusters (BGCs) for specialized...
t.co
🧵 GETCampy Stories #2 We spend a lot of time asking: **Where did this infection come from?** It sounds like a simple question. In reality, it's one of the hardest, and most important, questions in infectious disease epidemiology. 👇
A step forward in discovering Buchnera's key to the aphid's heart, published today! Thanks to Jerry Maeda and other authors--a great team -- and to the helpful reviewers #SymbioSky doi: doi.org/10.1038/s415...
A secreted endosymbiont protein essential for colonizing host cells - Nature
SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.
doi.org
🧵 New paper! 🚨 Delighted to see our GETCampy-Africa protocol published in BMJ Open. *Protocols for genomic epidemiology and source attribution of enteric bacteria causing diarrhoeal disease across Africa* @bmj.com @bmjmedicine.bsky.social 📄 bmjopen.bmj.com/content/16/6... 👇
Protocols for genomic epidemiology and source attribution of enteric bacteria causing diarrhoeal disease across Africa
Introduction Enteric bacterial pathogens are a major cause of diarrhoeal disease in low-income and middle-income countries, with complex transmission pathways involving human, animal and environmental...
bmjopen.bmj.com
Great week in The Gambia launching the Campylobacter Control Campaign (CCC). Researchers from 🇬🇲 🇳🇬 🇨🇮 🇬🇧 met at the MRC Unit The Gambia to plan a new multi-country genomic surveillance programme for Campylobacter. Excited to see this collaboration grow. #Campylobacter #OneHealth
We kick-off the Campylobacter Control Campaign meeting with partners from @lshtm.bsky.social, @biology.ox.ac.uk, @ineosoxford.bsky.social, alongside collaborators from Côte d’Ivoire, #Nigeria, #Egypt, #Ghana & #BurkinaFaso to finalise a genomic sampling framework to support future vaccine designs.
In Iquitos, Peru this week 🇵🇪 working on enteric pathogen genomics and surveillance in the Amazon. Science powered by collaboration, rain, food… and Inca kola!
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)! We're looking for someone keen on bioinformatics and microbiome evolution. Important info below on eligibility & URSA competition funding👇 www.findaphd.com/phds/project...
The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com
PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com
findaphd.com
Ben Pascoe @benizao.bsky.social @sheppardlab.bsky.social shining a light on C. coli - although less common than C. jejuni, it has higher levels of AMR. His work in Peru highlights the importance of this pathogen in LMICs due constant exposure with backyard livestock and antibiotic use 🇵🇪 #CampyUK2025
In our 80th year, we are highlighting some key discoveries in our journal archives. In 1976, Journal of Medical Microbiology took the lead in publishing research on Clostridium difficile as a pathogen - doi.org/10.1099/0022... #JMM
Stuck. Trapped. Flattened. ‘The Weight of a Man’ is an exploration of family, love and the search to escape pressures outside our control. 📚 Read @morrislau78.bsky.social's story in our upcoming anthology. Learn more and meet all our shortlisted authors: bit.ly/4dZRhIB
Keynote spotlight: We're thrilled to welcome Professor Christine Szymanski (University of Georgia) to #CampyUK2025 in Oxford! She’ll be sharing insights into the Campylobacter glycome and its role in persistence and disease. 📅 Sept 24–25 🔗 campyuk.web.ox.ac.uk/speakers#col...
"It no longer exists" The Covid Inquiry heard evidence this week that the testing infrastructure built up in 2020 has been completely dismantled. Prof. Alan McNally: "If Sars 3 happens in December, we will be exactly where we were in January 2020" An insult to those we lost.
🚨 Abstract submissions for CampyUK 2025 are now open! Join us in Oxford (24–25 Sept) to explore the latest in Campylobacter research. 🗓 Deadline: 31 July 🔗 campyuk.web.ox.ac.uk/home #CampyUK2025 #Microbiology #AMR #OneHealth
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campyuk.web.ox.ac.uk
Our latest preprint is out describing amr.watch - a platform for monitoring AMR trends from global genomics data: www.biorxiv.org/content/10.1... (1/6)
Geng Zou analysed ~6.5K S. suis genomes 🐷 🦠 & identified the protective capsule 'switch' that facilitates human infection, which has implications for preventing and treating zoonotic infections. @Lucy_Weinert @camvetschool.bsky.social #Microbio25
Make sure to check out the Understudied Bacterial Pathogens session tomorrow. We have a brilliant line up of speakers, including invited talks from Esh Mahenthiralingam and @sylvainbrisse.bsky.social #Microbio25 @microbiologysociety.org @alanmcn1.bsky.social @sheppardlab.bsky.social
I'll be giving a talk on LIN codes for Neisseria meningitidis today at 4pm in the Genetics & Genomics forum. Please come along and have a listen. It is such an exciting (& up and coming) area. @microbiologysociety.org #MicroBio25
I’ve been dabbling with different writing styles to make “behind the paper” type posts a bit more interesting… pascoelab.com/news-and-blog
PascoeLab
Welcome to Pascoe Lab global Pathogen Genomics & evolution
pascoelab.com
🚨 What's new in #Campylobacter research in 2025? 🚨 Check out these groundbreaking studies shaping the field ahead of #CampyUK2025! 🦠👇
The letter contains some fascinating insight into workings of a society operated paper vs a for-profit one, and mentions figures specific to operation of MBE. Well worth a read if you're interested in academic publications landscape.
Society for Molecular Biology and Evolution@official-smbe.bsky.social · last yr.
New paper alert 🚨 Genomic insights into extended-spectrum β-lactamase- and plasmid-borne AmpC-producing Escherichia coli transmission between humans and livestock in rural Cambodia. Incredible effort from Ebraheem Elmarghani and others for their contributions! 👏💩🧫🦠🧬 doi.org/10.1099/jmm....
Genomic insights into extended-spectrum β-lactamase- and plasmid-borne AmpC-producing Escherichia coli transmission between humans and livestock in rural Cambodia
Introduction. The global spread of extended-spectrum cephalosporinase-producing Escherichia coli (producing extended-spectrum β-lactamase or plasmid-borne AmpC, hereafter ESC-Ec) is a major public hea...
doi.org
Really exciting work: The Salmonella Colicin Col1b cannot only KILL a competing E. coli population, but also AMPLIFY metabolic contributions of susceptible bacteria by liberating β-gal… From @nic-ler.bsky.social. @kroegerlab.bsky.social, Andrew Cameron and others ‼️ academic.oup.com/ismej/advanc...
Lysis of Escherichia coli by colicin Ib contributes to bacterial cross-feeding by releasing active β-galactosidase
Abstract. The diffusible toxin ColIb produced by Salmonella enterica serovar Typhimurium SL1344 is a potent inhibitor of Escherichia coli growth. To identi
academic.oup.com
Our paper describing the microGWAS pipeline was published yesterday in Microbial Genomics. Lots of fixes and additions to the code/documentation since the preprint, including a hard to reproduce bug that only showed up in a specific HPC 🥵 www.microbiologyresearch.org/content/jour...
microGWAS: a computational pipeline to perform large-scale bacterial genome-wide association studies
Identifying genetic variants associated with bacterial phenotypes, such as virulence, host preference and antimicrobial resistance, has great potential for a better understanding of the mechanisms inv...
microbiologyresearch.org
🚨 We're very happy to announce the #CampyUK2025 meeting in Oxford (@ox.ac.uk), which will focus on #AMR in collaboration with @ineosoxford.bsky.social 🗓️Save the date: 24th-25th September 2025 📝Register your interest on our website: campyuk.web.ox.ac.uk
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Why now? Campylobacter infections are on the rise globally, with increasing levels of antimicrobial resistance (AMR) making treatment more challenging. As the world’s most common bacterial cause of gastroenteritis, Campylobacter poses a growing public health threat, yet effective interventions remain limited. There is an urgent need for research into novel and sustainable strategies to mitigate its impact—spanning genomics, surveillance, food safety, and public health interventions.
campyuk.web.ox.ac.uk
MicrobesNG POPUP Conference is coming to Norwich! It's a FREE #MicrobialGenomics conference 3rd Jul ECR's submit your abstract (talk or poster) by 3rd Apr www.surveymonkey.com/r/POP_UP_NOR Please repost! Organised with @getgenome.bsky.social & @norwichmicro.bsky.social #MNGPopUp #ECR #MicroSky
Ecological insights into the microbiology of food using metagenomics and its potential surveillance applications. Published #OpenAccess and fee-free in #MGen using a #PublishAndRead agreement: https://buff.ly/40EUUxr
