Wildfires and heatwaves: Expert analysis on public health impact

With wildfires and a heatwave currently raging through Europe, Dr Kim van Daalen, Environmental Epidemiologist in the Cardiovascular Epidemiology Unit at the University of Cambridge and Research Assoc...

cam.ac.uk

Inouye Lab - Publications

Google Scholar Inouye Lab authors * denotes equal contribution

inouyelab.org

PGS Catalog - Chen HH, Nature (2025) (Publication)

The Polygenic Score (PGS) Catalog is an open database of published PGS and the relevant metadata needed to apply and evaluate them correctly.

pgscatalog.org

Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans - Nature Ecology & Evolution

Despite their detrimental health effects, disease loci persist in human populations. This study shows that disease-risk alleles are generally associated with reduced longevity and increased fertility,...

nature.com

Reading list: Intestinal nutrition, microbiome GWAS, GLP-1 & AI stuff

Some new articles in the reading list. I’ll probably do a little break for those during the summer holidays. Have a good one! (a) Microbiome and population health Genomic landscape of the human vagina...

mericlab.com

AI-altered images on birdwatching forums putting research at risk

Experts warn increase in enhanced photos on birding platforms creating fake sightings, threatening credibility of tool used by scientists

theguardian.com

On a windswept Norwegian island, one turbine blade was painted black, and the white tailed eagles stopped dying under the rotors

Dozens of wind turbines stand across its treeless ground, spinning day and night in the salt wind.

share.google

Citizen science platforms must mitigate against the threat of generative AI

Nature Ecology & Evolution - Citizen science platforms must mitigate against the threat of generative AI

rdcu.be

Bacteria sense virus-induced genome degradation via methylated mononucleotides

Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...

science.org

Fall in international student numbers ‘cost UK £2.9 billion’

Latest cost-benefit analysis finds overseas enrolments generate nearly 10 times more money for UK than they take away

timeshighereducation.com

Who owns your peer review?

The reward for reviewing has quietly become an asset on someone else's balance sheet.

academicrenewal.substack.com

Dorado v2.0.0 part 3: methylation

a blog for miscellaneous bioinformatics stuff

rrwick.github.io

Widespread immune systems protect bacteria against conjugative plasmids

Conjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells. Although they can introduce beneficial traits such as antibiotic resistance to recipi...

biorxiv.org

E. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrients - Molecular Systems Biology

Although in the wild bacteria likely spend most of their time deprived of nutrients and slowly starving to death, very little is known about how bacteria adapt their phenotype to starvation. Here we combine microfluidics with quantitative fluorescence microscopy of transcriptional reporters to comprehensively quantify growth and gene expression at the single-cell level in E. coli during carbon starvation. We find that all cells immediately stop growing upon loss of carbon source and that almost all remain alive for over 30 hours. Furthermore, entry into starvation triggers a dynamic expression program that is remarkably homogeneous across single cells, but highly variable across genes, causing dramatic remodeling of the proteome early in starvation. We further show that, as protein production and the rate of protein degradation both decay approximately exponentially, protein concentrations become essentially ‘frozen’ after the first 5 to 10 hours, setting phenotypes for several days of starvation. Finally, using experiments in which gene expression is inhibited for different periods, we show that protein production in the first 5 hours is crucial for protecting cells from stresses late in starvation.

doi.org

Why paying peer reviewers works, according to a journal’s editor-in-chief

A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.

nature.com

An ECG biomarker for sudden cardiac death discovered with deep learning - Nature

A deep-learning model trained on electrocardiogram (ECG) waveforms identifies an easily visible biomarker that predicts sudden cardiac death more accurately than the current clinical state of the art.

nature.com

Italy Approves the First Law Recognizing Obesity as a Chronic Disease - EASO

Historic Recognition Until now, obesity—despite being one of the most widespread and impactful health conditions—was often perceived as an “individual problem,” linked mainly to personal choices and r...

easo.org

Extreme heat and cause-specific risk of hospital admission in the adult population in England: a case time series analysis

Objectives This study investigated the impact of heat on the risk of hospital admission due to a range of health conditions in England. Design We used records of over 4 million hospital admissions in...

bmjopen.bmj.com

Apitegromab for lean mass preservation during tirzepatide-induced weight loss: a randomized, double-blind, placebo-controlled phase 2 trial - Nature Medicine

In the phase 2 EMBRAZE study, participants receiving tirzepatide and apitegromab lost less lean mass compared to participants receiving tirzepatide and placebo.

dlvr.it

Guest Lecture 17 June 2026, does the shingles vaccine prevent dementia?

YouTube video by Nuffield Department of Primary Care Health Science

youtu.be

Case fatality rate for Ebola virus disease in west Africa

The case fatality rate (CFR) for the 2014 Ebola outbreak in west Africa has been widely reported to be much lower than for most previous outbreaks.1 However, this low rate is not necessarily a feature...

thelancet.com

Genomic landscape of the human vaginal microbiome is linked to host genetics and population of origin - Nature Genetics

Metagenomics, coupled with genome-wide association analyses, highlights population-specific patterns of variation within the vaginal microbiome and identifies host genetic loci associated with vaginal...

nature.com

A plasmid-encoded H-NS protein selectively binds its own plasmid

H-NS is an abundant nucleoid-associated protein found in Enterobacterales species. Some conjugative plasmids encode H-NS homologues, which are thought to facilitate plasmid maintenance and reduce the ...

biorxiv.org