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Benedetta Bolognesi

@bennibolo.bsky.social

Biologist, Explorer. Group Leader @ibecbarcelona.eu‬ Protein Phase Transitions.

29 Posts430 Follower527 Folgt
Benedetta Bolognesi@bennibolo.bsky.social · 4mo ago

Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.

IBEC | Institute for Bioengineering of Catalonia@ibecbarcelona.eu · 4mo ago

🔬 Investigadores de l'#IBEC creen un mapa mutacional de l’amilina que mostra com certes mutacions poden accelerar o frenar la formació d’agregats tòxics vinculats a la diabetis tipus 2.  📖 https://ibecbarcelona.eu/an-unprecedented-mutation-map-reveals-how-amylin-mutations-influence-type-2-diabetes/

Kalli Kappel@kallikappel.bsky.social · last yr.

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out! rdcu.be/eq975

Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq

Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

rdcu.be

Benedetta Bolognesi@bennibolo.bsky.social · last yr.

New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:

Anna Arutyunyan@immunobananna.bsky.social · last yr.

Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall? In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇 www.science.org/doi/10.1126/...

Danielle Beckman@daniellebeckman.bsky.social · last yr.

A black hole in the early universe? Sometimes I like to imagine that I operate a telescope, not a microscope 😁. The hole in the middle of the image is actually a blood vessel. The stars are astrocytes🟡 in the human brain, interacting with beta-amyloid🔵. The brain is from a donor with #Alzheimer.

Confocal microscopy photo
Benedetta Bolognesi@bennibolo.bsky.social · last yr.

And what a great talk to end #VariantEffect25 ! Thanks to the amazing crowd that travelled to Barcelona and made MSS25 such a fantastic meeting. Lots to think about now! 🧦🗺️☀️

Jonathan Frazer@jonnyfrazer.bsky.social · last yr.

And now, the final talk of #VariantEffect25. @roseorenbuch-art.bsky.social from Harvard Medical School presents work from our long-standing collaboration, and one that’s very close to my heart: Proteome-wide model for human disease genetics

John Bull@garius.bsky.social · last yr.

“If she wants to know something specific, but doesn’t want people to notice her asking questions, she should simply make incorrect statements while in the company of experts. Her companions will correct her, especially if they're men.” - Advice for female agents in WW2, provided during SOE training

Dave Baltrus 🦦@surtlab.bsky.social · last yr.

In my 25 years since high school I’ve seen 1. HIV/AIDS go from death sentence to manageable with drugs 2. Cystic fibrosis go from pretty much an extended death sentence to manageable with drugs 3. Sickle cell go from a horrible disease to (almost maybe) cured by gene therapy Simply incredible