Bess Frost
@bessfrost.bsky.social
Salame-Feraud Director, Center for Alzheimer’s Disease Research | Brown University
Welp, there goes that one. grants.nih.gov/grants/guide...
NOT-NS-26-002: Notice of Change: Early Expiration of NINDS Ruth L. Kirschstein National Research Service Award (NRSA) for Training of Postdoctoral Fellows (F32 Clinical Trial Not Allowed)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Change: Early Expiration of NINDS Ruth L. Kirschstein National Research Service Award (NRSA) for Training of ...
grants.nih.gov
Congrats to DR. Morgan G. Thomas for a successful PhD defense!!
I had a lot of fun talking life and science with Sia Gullapalli, high schooler and host of the podcast “Her Path to Success!” open.spotify.com/episode/5Coh...
Mapping Memory: Dr. Bess Frost on Neurodegeneration, Resilience, and the Future of Brain Research
open.spotify.com
Congrats to Alvin and Ryan!
Carney Institute for Brain Science@carneyinstitute.bsky.social · 6mo agoBig congrats to Yu-Wen Alvin Huang and Ryan O'Rourke! Their start-up, Acre Therapeutics, is a winner of the 2025 NIA Start-Up Challenge: www.nia.nih.gov/research/sbir/startup-challenge/2025-winners-finalists-and-mentors
Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...
cell.com
asamelson@asamelson.bsky.social · 6mo agoAfter a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex... TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments. More below 👇
Frost lab paper alert! This study was led by Dr. Paul Ramirez, Lead Biostatistician for the Brown University Center for Alzheimer’s Disease Research: alz-journals.onlinelibrary.wiley.com/doi/epdf/10.... 1/9
Long‐read sequencing reveals genomic and epigenomic variation in the dark genome of human Alzheimer's disease
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alz-journals.onlinelibrary.wiley.com
Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function www.nature.com/articles/s41...
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau - Molecular Psychiatry
Molecular Psychiatry - Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau
nature.com
New Frost lab preprint from @SohnClaira: “Elevation of the mechanically-sensitive protein emerin links nuclear mechanotransduction to tau-induced cytoskeletal remodeling in neurons” www.biorxiv.org/content/10.1... 1/9
New Frost Lab Paper/Dataset Alert! bmcgenomics.biomedcentral.com/articles/10.... Congrats to co-first authors @PaulRamirez42 and Dr. Gabbe Zuniga. @carneyinstitute.bsky.social 1/5
Long-read sequencing-based analyses of the adult Drosophila brain transcriptome in physiological and pathological settings - BMC Genomics
Optimal brain function requires that neurons carry out extensive post-transcriptional RNA processing to produce a vast diversity of transcripts. Accurate reconstruction and quantification of highly pr...
bmcgenomics.biomedcentral.com
We are excited to announce a new open search for a tenure track Assistant Professor position within the Brown University Center for Alzheimer's Disease Research! Apply here: apply.interfolio.com/175427
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💫NEW: Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control #GeneExpression and human #StemCell fate. 👉https://rdcu.be/eJqGP bit.ly/4gYgJjm
A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate - Nature Cell Biology
Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control gene expression and human stem cell fate.
bit.ly
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
nature.com
Brain on standby — how torpor made ‘tauopathy’ reversible — a Journal Club article by Nina M. Rzechorzek @dynamicbrain.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...
Brain on standby — how torpor made ‘tauopathy’ reversible - Nature Reviews Neuroscience
In this Journal Club, Nina Rzechorzek explores a 2003 article showing that, during hibernation, ground squirrels reversibly accumulate highly phosphorylated tau in the brain (a hallmark of Alzheimer’s...
nature.com
I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.
If you are at #AAIC25 and want to see new, unpublished data on #tau, #retrotransposons and circular DNA, check out poster #847 by Morgan Lambert @BrownUniversity from 3:30-4:15 today!
If science in the US ends due to continuous funding cuts, I think I’ll try to join a scientific conference dance troupe. #AAIC2025
1/2 Great article by Amber Dance in @knowablemag.bsky.social, a lay explanation of the @annualreviews.bsky.social that @bessfrost.bsky.social and I wrote about the “retrotransposon storm” hypothesis of Neurodegeneration. knowablemagazine.org/content/arti...
How rogue jumping genes can spur Alzheimer’s, ALS
Our genomes are peppered with DNA segments called retrotransposons that can move from place to place. When unleashed, some can kill nerves and promote inflammation — a discovery that may inspire treat...
knowablemagazine.org
More complete analysis of NIH outlays (or lack thereof) from grant-watch.us grant-watch.us/posts/trends...
Trends in NIH outlays: Brown, Columbia, Cornell, and Northwestern funding drops to $0 – Grant Watch
grant-watch.us
The Trump HHS spokesman Andrew Nixon is a flat liar. Peer review selects the best grants and awards them for several years and that’s it. The Trump admin has politicized American science in an unprecedented way and now lies about it. Journalists: ask scientists about what’s happened for the truth.
In case you needed a smile this Tuesday: 10-month-old baby KJ, who received a bespoke gene-editing therapy after a six month scientific sprint - "graduated" from the hospital @childrensphila.bsky.social today and went HOME! YAY SCIENCE! Here's his story: wapo.st/451ZQjT
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Marc Dionne@marcsdionne.bsky.social · last yr.My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate. www.philanthropy.cam.ac.uk/give-to-camb...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference
Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The...
alz-journals.onlinelibrary.wiley.com
An amazing PhD student in my lab just received notice that her individual F31 fellowship focused on Alzheimer’s disease/Tauopathy was terminated.
Progress with rapid & accessible biomarkers of neurodegeneration! Fujirebio received FDA clearance for a blood assay that predicts amyloid plaque pathology associated with Alzheimer's disease. The assay measures the plasma ratio of pTau217:β-Amyloid1-42. www.fujirebio.com/en-us/news-e... 🧪
www.nbcnews.com/health/healt...
One of the country's leading Alzheimer's projects is in jeopardy
A pause to NIH funding has researchers scrambling for contingency plans at the University of Washington’s Alzheimer’s Disease Research Center. The center’s brain bank is preserving more than 4,000 bra...
nbcnews.com
The title tells the story and the 5 graphs amplify it www.nature.com/articles/d41...
154 million lives and counting: 5 charts reveal the power of vaccines
But public-health specialists worry that misinformation and funding cuts could affect vaccination rates.
nature.com
Does anyone know what kind of jellyfish this is? Spotted on a beach in Narragansett Bay.
