Celeste Karch
@karchlab.bsky.social
Professor. Washington University School of Medicine. Genomics, stem cell models, molecular mechanisms of AD and other tauopathies. She/her. www.karchlab.wustl.edu
New preprint 🥳 Gamma secretase isnt a single enzyme, multiple GSEC exist depending on which subunits are incorporated into the complex. We made PSEN1 & PSEN2 knockouts to study the impact of different GSEC in neurons & microglia Led by @celarber.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Excited to share new work led by Sam Swift in the lab identifying NINL as a modifier of tau seeding
Integrative genomic and functional analyses reveal NINL as a modulator of tau aggregation
INTRODUCTION Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD), yet the genetic and molecular pathways that disrupt protein homeostasis remain poor...
alz-journals.onlinelibrary.wiley.com
Beyond excited to share new work using super resolution microscopy to reveal how a tau mutation drives early changes in the autophagy lysosome pathway led by the amazing Dr Mirfakhar
A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia - Nature Communications
Researchers show that a disease-causing Tau mutation disrupts the autophagy-lysosome pathway in human neurons, leading to Tau accumulation, and that enhancing autophagy can partially restore protein c...
nature.com
Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: Neuron www.cell.com/neuron/fullt...
Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition
Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease, leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans alike. Suppressing APOE4-i...
cell.com
UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration www.nature.com/articles/s41...
UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration - Nature Neuroscience
ALS/FTD-linked mutations in UBQLN2, a protein quality control factor, impair degradation of enzymes essential for mitochondrial lipid catabolism, leading to metabolic dysfunction and neurodegeneration...
nature.com
Transgender rights = human rights. In many countries around the world, the rights of trans people are under attack. This International Transgender Day of Visibility, we continue to work for a world where all people can enjoy their rights fully.
Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...
Guidelines for T cell nomenclature www.nature.com/articles/s41...
Guidelines for T cell nomenclature - Nature Reviews Immunology
This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...
nature.com
medicalxpress.com/news/2025-11...
Newly discovered RNA molecule could limit protein aggregation and prevent neuronal damage
Neurodegenerative diseases, such as Alzheimer's disease and dementia, are medical conditions that entail the progressive loss of neurons and a decline in brain function. Past studies have found a link...
medicalxpress.com
!["[c]learly Rosy had to go or be put in her place”](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:an2lkmy3huazryrvir2strds/bafkreieh3gaaje45rowrtp3xg5x6kmnzz4ewpaayv4kteikj5uwyvkvk74)
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
Our first Family Social Hour is today at 8PM! Join us to meet other #MAPTFTD families ❤️ #cureMAPTFTD #FTD us06web.zoom.us/meeting/regi...
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia. Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs. Alzforum www.alzforum.org/news/researc... Preprint www.biorxiv.org/content/10.1...
Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function www.nature.com/articles/s41...
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau - Molecular Psychiatry
Molecular Psychiatry - Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau
nature.com
Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
Should PIs at institutions where NIH funds have been frozen still agree to participate in NIH study sections?
Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!
ucl.ac.uk
LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data
bioRxivpreprint@biorxivpreprint.bsky.social · last yr.LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data https://www.biorxiv.org/content/10.1101/2025.04.28.650893v1
Everyone should contact their us congress members and tell them not to cut SNAP (food stamps). secure.everyaction.com/lmBv70YdQkCu...
URGENT ACTION ALERT: Historic Threat to SNAP – Keep The Pressure On
secure.everyaction.com
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read! www.cell.com/neuron/abstr...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...
cell.com
Great article featuring pioneering work from the Frost lab along with promising clinical trial data @bessfrost.bsky.social
Could blocking ‘jumping genes’ help fight disease and aging?
The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own
science.org
Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social! Registration 🔗 us02web.zoom.us/meeting/regi... #NewVisionResearch #ProfessionalDevelopment
Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration
Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.
Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.
us02web.zoom.us