Very excited to share our new preprint: Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling Great team effort and collaboration, led by MD/PhD student @kunalshroff.bsky.social in my lab - read more details in his post below:

Kunal Shroff@kunalshroff.bsky.social · last mo.

I am so excited to share our new preprint! www.biorxiv.org/cgi/content/... This work uncovers a key molecular mechanism that control synapse-specific exposure of the canonical “eat-me” signal phosphatidylserine!

Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

cell.com

asamelson@asamelson.bsky.social · 6mo ago

After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex... TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments. More below 👇

Congratulations on passing your qualifying exam, Reet Mishra! 🍾 #kampmannlabproud

Kampmann lab Halloween costume this year: Revenge of the lab rats (Including several KO mice) Happy 👻🎃

Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia. Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs. Alzforum www.alzforum.org/news/researc... Preprint www.biorxiv.org/content/10.1...

Apply by Oct 15 - please spread the word!

Martin Kampmann@kampmann.bsky.social · last yr.

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! aprecruit.ucsf.edu/JPF05702

Find the CrAAVe-seq plasmid pAP215 here: www.addgene.org/217635/ Exciting work, thanks for sharing!

Martin Kampmann@kampmann.bsky.social · 12mo ago

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com! Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab. www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes @kampmann.bsky.social @ivlrose.bsky.social www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience

The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

nature.com

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com! Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab. www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience

The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

nature.com

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! aprecruit.ucsf.edu/JPF05702

Very honored to receive this year's Byers Award in Basic Science! Huge thanks to my lab and our funders for enabling our research on Alzheimer's disease and related dementias. www.ucsf.edu/news/2025/07...

Farewell party for 4 great lab members, excited for their next adventures: Biswa Ramani (starting the Ramani Lab ‪@ucsanfrancisco.bsky.social‬), @venushagan.bsky.social (PhD @ucsanfrancisco.bsky.social‬), Cristian Chavira (PhD ‪@uwmadison.bsky.social‬), Kean Ehsani (Ramani lab). Thanks & best wishes

Stand up for science - stand up for the NIH! I just signed the support letter for the #BethesdaDeclaration. Please consider signing as well: www.standupforscience.net/bethesda-dec...

Bethesda Declaration — STAND UP FOR SCIENCE

Support NIH Staff Now!

standupforscience.net

Farewell to Emily Marzette. Thank you so much for your many contributions to the lab! We will miss you lots but are excited for you to start grad school at UCLA! 🎉

New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures

Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

cell.com

www.alz.org/news/2025/ke...

Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research

The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.

alz.org

Congratulations Rudra Bose, on passing your qualifying exam with flying colors! 🎉🎉🎉 #kampmannlabproud

Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢 Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪 Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!

Takeshi Uenaka@tuenaka.bsky.social · last yr.

Losing sleep over #iPSC transgene silencing after differentiation? Same here — too many times😭 So we built a PiggyBac construct that resists silencing. Expression stays ON, even after differentiation. Our #preprint is out👇 🔗 www.biorxiv.org/content/10.1... Supported by @cziscience.bsky.social

As Trump & Musk tear down our federal science agencies & jeopardize U.S. global science leadership, CA needs to step up. I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵

Congratulations Dr. @parkergrosjean.bsky.social! 🎓🎉🎉🎉 Thank you for your contributions to the Kampmann lab & UCSF - combining AI/ML with functional genomics to uncover regulators of neuronal activity. We are missing you already - but excited for your next adventures at @insitro.bsky.social!

It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:

Excited for our iAssembloid work, led by @emmyli.bsky.social to be featured on the cover of today's issue of @cp-neuron.bsky.social

Neuron@cp-neuron.bsky.social · last yr.

Our latest issue is out! www.cell.com/neuron/current On the cover is an iAssembloid, a 3D co-culture of human iPSC-derived brain cell types, that Emmy Li & coll. combines with CRISPRi screening to elucidate neuron-glia interactions Find the paper here: www.cell.com/neuron/fullt...

Honored and grateful to receive the 2025 Bowes Biomedical Investigator Award - along with my friend, colleague and collaborator @annamolofskylab.bsky.social 😊🎉🎉🎉 www.ucsf.edu/news/2025/02...

How to Build Bold Thinking to Foster Scientific Breakthroughs

Martin Kampmann, PhD, and Anna Victoria Molofsky, MD, PhD, are the 2025 recipients of the Bowes Biomedical Investigator award, which supports scientists who take novel approaches and have the potentia...

ucsf.edu

In this time of chaos - something good! We are excited to share our final (or near final) speaker list for the 3rd UCSF Full Circle Symposium 4/3-4/4 to highlight Native biologists! Please share the word and register to attend the webinar in person! More info: qbi.ucsf.edu/full-circle-...

Congratulations Dr. Olivia Teter! 🎓🎉🎉🎉 Thank you for your many contributions to the Kampmann lab - scientifically and socially. We will miss you lots. All the best for your next adventure at Calico!

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

Check out our new preprint: Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics Project led by @parkergrosjean.bsky.social - see his "blue-torial" below!

Parker Grosjean@parkergrosjean.bsky.social · last yr.

I am excited to announce the release of our BioRxiv preprint: “Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics”. 1/

Thank you Alzforum for featuring our work! CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions - project led by @emmyli.bsky.social www.alzforum.org/news/researc...

Our latest paper, led by Emmy Li, is out on Neuron today: CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions www.cell.com/neuron/fullt...

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions

Using a 3D co-culture system of iPSC-derived neurons and glia, termed iAssembloids, combined with CRISPRi-based screening, Li et al. investigate the effect of glial cells on neuronal activity and surv...

cell.com

www.cell.com/cell/fulltex...

Global organelle profiling reveals subcellular localization and remodeling at proteome scale

Organelle proteomics defines the cellular landscape of protein localization and highlights the role of subcellular remodeling in driving responses to perturbations such as viral infections.

cell.com