1/ NEW PAPER 🎉 🧵 We mapped the mutational processes shaping 959 prostate cancer genomes from the Pan Prostate Cancer Group (PPCG), integrating SBS, ID, CX and complex SV signatures. Eight footprints account for the processes in 85% of cases www.nature.com/articles/s41... @nature.com

Integrated signatures define mutational processes in prostate cancer - Nature

Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.

nature.com

Read our cool study out in @nature.com 🧬 great work by Andreas Gruber, André Vidas Olsen, @bhernando.bsky.social and Kevin Cheng. Co-led with @reimand.bsky.social and @gmaci.bsky.social Read post here: tinyurl.com/3abceaev Also great media coverage here: tinyurl.com/yz8mcb98

Very excited to see our study online today in Nature!!! Amazing tour de force collaborative effort and fantastic collaborators within the Pan Prostate Cancer Group (PPCG) 🥂 Biotech Research &… | J...

Very excited to see our study online today in Nature!!! Amazing tour de force collaborative effort and fantastic collaborators within the Pan Prostate Cancer Group (PPCG) 🥂 Biotech Research & Innovati...

linkedin.com

Nature@nature.com · last mo.

Nature research paper: Integrated signatures define mutational processes in prostate cancer go.nature.com/4xLwBNN

Check it now! 💫 Exited to share this preprint, the result of a fantastic collaboration between Sarah Aitken’s and Martin Taylor’s labs. During my secondment at @yalecancer.bsky.social @yalepathology.bsky.social, I contributed to explore how H&E images can be used to predict tumour genomics

Sarah Aitken@s-j-aitken.bsky.social · 3mo ago

🔬NEW PREPRINT🔬 Explainable machine learning relates histological to genomic pathology www.biorxiv.org/content/10.6... From John Connelly and Barbara Hernando @bhernando.bsky.social, co-led with Martin Taylor @mstaylor.bsky.social - along with others from #LCEConsortium #genomicPathology #ml #ai

🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]

Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

nature.com

Thanks for everything! I will miss being around in the lab but see you online 🫶🏻

Sarah Aitken@s-j-aitken.bsky.social · 10mo ago

It has been an absolute pleasure to host @bhernando.bsky.social here at @yalecancer.bsky.social for the last few months! I've learnt so much, and your generosity and enthusiasm will be greatly missed. Looking forward to future collaboration, friendship - and paella 🤩 @yalepathology.bsky.social

Had a lovely dinner today with members of @s-j-aitken.bsky.social’s lab to celebrate my recent preprint! Sharing these small milestones (and the joy that comes with them) with friends is just magic ✨

Barbara Hernando@bhernando.bsky.social · 11mo ago

📢 New preprint out! We are thrilled to introduce our framework to track #ongoingCIN by leveraging single-cell genomics and CIN signatures: www.biorxiv.org/content/10.1...

📢 New preprint out! We are thrilled to introduce our framework to track #ongoingCIN by leveraging single-cell genomics and CIN signatures: www.biorxiv.org/content/10.1...

Tracking ongoing chromosomal instability using single-cell whole-genome sequencing

Chromosomal instability (CIN) generates aneuploid genomes that are characteristic of most cancers. While bulk genome sequencing reveals historical CIN, it lacks the resolution to identify ongoing CIN ...

biorxiv.org

It was an honor to take part in the @yalepathology.bsky.social research retreat today! Great science, inspiring discussions, a fun “guess who?”, and wonderful people. Huge thanks to organizers for such a great work! Can’t believe only 2 months left to enjoy this amazing #AitkenLab team ✨

Sarah Aitken@s-j-aitken.bsky.social · 12mo ago

Today was our first Yale Pathology Department retreat - with Klaske, Barbara, Jacob, and Vanessa (we missed you Tanuja!) Great to present our work with a poster and two talks, share ideas, and meet new people 🇨🇦🇪🇸🇬🇧🇳🇱🇺🇸🌎 @yalepathology.bsky.social @bhernando.bsky.social

A trio of talks this week: Grand Rounds @jhu.edu yesterday. Then @bhernando.bsky.social (who has only been here a fortnight!) and I gave talks at the NYC Genome Integrity Discussion group @rockefeller.edu. Thanks for inviting us Agata Smogorzewska and Philipp Oberdoerffer @yalepathology.bsky.social

Exciting 3 months ahead at the #AitkenLab @yaleschoolofmed.bsky.social! 🤩 Huge thanks to @s-j-aitken.bsky.social for the warm welcome, and to @caixaresearch.bsky.social for supporting my research career at all levels ✨

Sarah Aitken@s-j-aitken.bsky.social · last yr.

🥳 Today we welcome Dr Bárbara Hernando @bhernando.bsky.social to the #AitkenLab @yaleschoolofmed.bsky.social Bárbara joins us from #CNIO as part of her @caixaresearch.bsky.social Postdoctoral Junior Leader Fellowship @yalepathology.bsky.social @yalecancer.bsky.social @cniostopcancer.bsky.social

#CNIOStopCancer develop test that predicts which patients will not respond to cancer chemotherapy. They have identified biomarkers which, in clinical practice, would allow for more effective treatments and the avoidance of side effects. http://bit.ly/465QqnR

Un estudio del #CNIOStopCancer descubre biomarcadores que predicen qué pacientes no responderán a la quimioterapia contra el cáncer. Podrían servir para descartar tratamientos que no van a funcionar, pero provocan efectos secundarios y son caros.  http://bit.ly/4lj1QJn

🚨Chemo treatment upgrade!🚨 Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇

💥New preprint from the @gmaci.bsky.social lab! Thrilled to share this major team effort, with #Angel as co-first author, now live on bioRxiv! Check out our threat to learn more about our work👇

Geoff Macintyre@gmaci.bsky.social · last yr.

If tumour genome evolution is deterministic, can we forecast genomic changes? Yes we can! At least for oncogene amps and tumour suppressor dels. @bhernando.bsky.social Angel Fernandez-Sanroman present our method for forecasting driver gene copy number change. Preprint: bit.ly/4kxF14y ⬇️1/

Flying back from Bologna after the Pan Prostate Cancer Group #PPCG meeting. 3 days of fruitful discussions with lovely colleagues at the best venue I have ever been 🤩

Day 1 at #AACR2025 from my side! Meanwhile, at the #EMBO workshop on Chromosome Segregation and Aneuploidy, Maria Escobar will be presenting our project on ongoing CIN in KRAS mutant pancreatic organoids! A must meeting for the #CIN community meetings.embo.org/event/25-ane...

Chromosome Segregation and Aneuploidy

Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …

meetings.embo.org

Ready for #AACR25! Excited for five full days of talks, posters and educational sessions in cancer research, and also for catching up with colleagues and friends 🤩