Next Pan Prostate Cancer Group (panprostate.org) paper out! This one looking at bacteria in prostate cancer . Please read the post below by lead author Abraham Gihawi @abrahamgihawi.bsky.social and check it out. doi.org/10.1038/s415...

Recovering anaerobic bacterial genomes in saliva, tumour and blood whole genome sequencing data from patients with prostate cancer - npj Biofilms and Microbiomes

npj Biofilms and Microbiomes - Recovering anaerobic bacterial genomes in saliva, tumour and blood whole genome sequencing data from patients with prostate cancer

doi.org

Abraham Gihawi@abrahamgihawi.bsky.social · last wk.

By digging into existing whole-genome sequencing data, we recovered 249 highly complete bacterial genomes from saliva, blood and tumour samples from men with prostate cancer rdcu.be/w1fzo5yefuja Here’s what we found 🧵👇

For more details on what was found see this post from Daria: lnkd.in/p/e4TPmVhU

The molecular heterogeneity and clinical impact of genomic driver alterations in prostate cancer - Nature Communications | Daria Kiriy

Excited to share that our latest study is now published in Nature Communications! 🍾 🎉 Using data from the largest prostate cohort cohort (PPCG), we systematically characterised the genomic driver la...

lnkd.in

Huge congratulations to Diogo Pellegrina, Daria Kiriy, and Kevin Cheng for leading this incredible piece of work, and to @reimand.bsky.social and @jweischenfeldt.bsky.social for driving the vision across the whole project. It was a great pleasure to contribute to this collaborative effort.

17/ Enormous effort from co-first authors Andreas Gruber (Konstanz), André Olsen (BRIC Copenhagen) and Kevin Cheng (OICR), and from @gmaci.bsky.social, @reimand.bsky.social and @jweischenfeldt.bsky.social who co-led it. Thanks to #PPCG, to the men who donated samples, and to our funders.

1/ NEW PAPER 🎉 🧵 We mapped the mutational processes shaping 959 prostate cancer genomes from the Pan Prostate Cancer Group (PPCG), integrating SBS, ID, CX and complex SV signatures. Eight footprints account for the processes in 85% of cases www.nature.com/articles/s41... @nature.com

Integrated signatures define mutational processes in prostate cancer - Nature

Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.

nature.com

Read our cool study out in @nature.com 🧬 great work by Andreas Gruber, André Vidas Olsen, @bhernando.bsky.social and Kevin Cheng. Co-led with @reimand.bsky.social and @gmaci.bsky.social Read post here: tinyurl.com/3abceaev Also great media coverage here: tinyurl.com/yz8mcb98

Very excited to see our study online today in Nature!!! Amazing tour de force collaborative effort and fantastic collaborators within the Pan Prostate Cancer Group (PPCG) 🥂 Biotech Research &… | J...

Very excited to see our study online today in Nature!!! Amazing tour de force collaborative effort and fantastic collaborators within the Pan Prostate Cancer Group (PPCG) 🥂 Biotech Research & Innovati...

linkedin.com

Nature@nature.com · 2mo ago

Nature research paper: Integrated signatures define mutational processes in prostate cancer go.nature.com/4xLwBNN

www.eurekalert.org/news-release... medicalxpress.com/news/2026-09...

Scientists reveal what damages the DNA in most prostate cancers

The work is based on reading the complete DNA of 959 tumours from men in seven countries — the largest set of prostate cancer genomes examined in this way. Eight faulty cellular processes togeth...

eurekalert.org

If one paper out today wasn't enough, from the PanProstate Cancer Group (panprostate.org), we've got another outstanding paper. This one looking at biallelic epigenetic inactivation in the first PPCG data set. Great work. Lucky to be involved. doi.org/10.1038/s414...

Pan Prostate Cancer Group - Home

PanProstate Cancer Group website.

panprostate.org

www.linkedin.com/feed/update/...

Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications | Thorsten Schlomm

Metastasis does not begin when we detect it — it begins when tumour evolution selects the cells that will spread. In our new Nature Communications study, we show that prostate cancer is not a uniform...

linkedin.com

Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.

Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications

The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples fro...

nature.com

Joachim Weischenfeldt, Ashani Weeraratna, Karuna Ganesh, Elaine Fuchs, Ana Anderson, and Sheetal Hardikar discussed "Endogenous Mechanisms of Early Onset Carcinogenesis" at #AACRearlyonset25. @jweischenfeldt.bsky.social @ashi-w.bsky.social @karunamdphd.bsky.social @thefuchslab.bsky.social

Great participation and discussions at our PhD course in Cancer Genomics at @bric-ucph.bsky.social organized together with prof Jesper Andersen. Exciting talks and interactions with external speakers incl @ecuppen.bsky.social and @matlupien.bsky.social 🙏💪👇

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned

AACR Conference - Rise in Early-Onset Cancers www.aacr.org/meeting/aacr...

So excited to see it out in @science.org. See details below in the 🧵 from stellar former PhD student @bfurtwa.bsky.social. Many thanks to all involved, especially Blueskyless Nil Uresin and Sabrina Richer and my co-PIs @fabiantheis.bsky.social and @erwinschoof.bsky.social

We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Now published in @science.org together with @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social. www.science.org/doi/10.1126/... 🧵

Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget. https://go.nature.com/4gM6oW4

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order

The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

go.nature.com

“I’ve spent over five decades as a scientist in academia & the federal government, including as director of the National Institutes of Health. Never before have I seen my profession so politicized as it is now under the Trump administration” #AcademicSky 🧪 www.nytimes.com/2025/02/14/o...

Opinion | American Science is Under Attack (Gift Article)

The Trump administration hobbles research and endangers the public health.

nytimes.com