Bina Singh
@binasingh.bsky.social
Studying viruses where it matters most- inside the cell, in situ Postdoc at Umeå University
Great #postdoc #opportunity at #FMI & #Novartis, worth a look if you're in the field!
FMI science@fmiscience.bsky.social · 3mo agoPostdoc opportunity at FMI + Novartis Biomedical Research 🧬 The Dahmane lab (FMI) & Farady lab (Novartis) are seeking a postdoctoral researcher to study how extracellular inflammasome particles propagate inflammation during neurotropic RNA virus infection. Apply by May 31: www.fmi.ch/education-ca...
📢 We are now recruiting a PhD student in Structural and Molecular Virology in Sweden 🇸🇪 Work on RNA viruses using cryo-EM and in situ cryo-ET, with access to world-class microscopy infrastructure Perfect for candidates with backgrounds in biochem, structural bio, and virology More info ⬇️
New Title Alert: MemBrain-v2- is a tool that includes MemBrain-seg, MemBrain-pick, MemBrain-stats, and several Napari tools. Learn more here: buff.ly/U3s12Ic #SBGrid #SBGridSoftware
CellArchLab/MemBrain-v2
This is the main repository for MemBrain v2. It includes MemBrain-seg, MemBrain-pick, MemBrain-stats, and several Napari tools. - CellArchLab/MemBrain-v2
buff.ly
Our paper is finally out! I’m proud to share this collaborative work using FIB milling and cryo-electron tomography to study tick-borne flavivirus replication. Thanks to all co-authors and collaborators — great teamwork #CryoET #ElectronTomography #Virology #Flavivirus #Microscopy #StructuralBiology
Lars-Anders Carlson@lacarlson.bsky.social · 7mo agoI am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look! #virology #teamtomo www.nature.com/articles/s41...
Emerging roles of lipids in the flavivirus life cycle www.cell.com/trends/micro...
Emerging roles of lipids in the flavivirus life cycle
Flaviviruses, such as Dengue, Zika, and West Nile virus, cause a significant global health burden and have earned attention as high-pandemic risk pathogens. Flaviviruses interact closely with cell mem...
cell.com
🎄✨ Season’s Greetings from PDBe ✨🎄 The PDBe wishes you a very Merry Christmas and a Happy New Year. We are delighted to share our jointly designed EMDB/PDBe Christmas card with you. It has been a busy year, and we look forward to seeing you in the New Year.
Providing order amongst constant traffic: #LMBResearch from Sean Munro (@cellbiol-mrclmb.bsky.social) with John Briggs (@mpibiochem.bsky.social) reveals how GOLPH3 allows COPI vesicles to distinguish between Golgi residents & ER-bound proteins. Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
Delighted to see our work in press! 🙌🔬🧠 Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions. Excited to see where in tissue structural cell biology goes next 👀! #liftlaughlove #teamtomo #whopper
Michael Grange@michaelgrange.bsky.social · last yr.Proud to share our latest paper. doi.org/10.1016/j.cr... Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue. Structural biology in tissue is well and truly here! @rosfrankinst.bsky.social
"A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis" www.nature.com/articles/s41...
A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis - Nature Communications
There are no vaccines or antivirals available against enterovirus D68. Here, the authors report Jun6504 as a 2C inhibitor and show that it provides broad-spectrum antiviral activity against EV-D68, EV...
nature.com
structure prediction is not science if not experimentally validated. period
Diego del Alamo@delalamo.xyz · last yr.Predicted structures from the AFDB are poor substitutes for experimental structures when training inverse folding NNs. Here, authors show that this is because they are "too perfect", and passing them through a custom-trained AFDB-to-PDB NN helps fix this threadreaderapp.com/thread/19384...
Cryogenic Electron Tomography Redefines Herpesvirus Capsid Assembly Intermediates Inside the Cell Nucleus. www.biorxiv.org/content/10.1101/2025.06.27.661840v1 #cryoEM
Just what happens when cryo conditions get too creative: ice contamination feels like sculpture. #CryoFIB #CryoEM #ElectronMicroscopy #MicroscopyArt #MicroscopyMonday
"Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET" www.nature.com/articles/s41...
Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET - Nature Communications
This study delineates the full sequence of SARS-CoV-2 spike-mediated membrane fusion and shows how S2-targeting antibodies inhibit this process, using a near-native functional fusion system and cryo-e...
nature.com
My PhD student @rupeshjayachandran.bsky.social wrote a comment piece on recent #nipah virus #polymerase structures, especially the one reported by @salafernanda.bsky.social from the lab of @haukehillen.bsky.social Please check it out 😊 www.sciencedirect.com/science/arti...
From disorder to order: cryo-EM reveals RNA-dependent remodeling of Nipah virus polymerase
A flurry of recent structural studies have focused on the polymerase complex of the deadly zoonotic pathogen Nipah virus (NiV). These include a report…
sciencedirect.com
