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Osama Harraz

@osamaharraz.bsky.social

Assistant Professor, Bloomfield Professor in Cardiovascular Research - decoding the complexity of vascular physiology and blood flow control, one ion channel at a time. Univ. of Vermont www.HarrazLab.com

77 Posts972 Follower946 Folgt
Jorge Castorena@jcastorena.bsky.social · 2mo ago

Our newest study is now published. Here we show that GLP-1Rs are expressed in the lymphatic vasculature and enriched in LECs. And pharmacological activation by semaglutide enhances the pumping capacity of collectors. onlinelibrary.wiley.com/doi/10.1111/...

GLP‐1 Receptors Are Enriched in the Lymphatic Endothelium and Their Pharmacological Activation With Semaglutide Improves the Pumping Capacity of Lymphatic Vessels

Objectives Recent clinical studies have suggested that glucagon-like peptide-1 receptor (GLP-1R) agonists may be effective therapies to treat or reduce the risk of developing secondary lymphedema. I.....

onlinelibrary.wiley.com

Osama Harraz@osamaharraz.bsky.social · 3mo ago

Pew Latin American Fellows Program: Remarkable opportunity for Latin America🌎researchers to pursue postdoctoral training in the US. ➡️ If you consider applying and your interests connect with ours (www.HarrazLab.com), I’d be glad to explore if I could serve as a sponsor. www.pew.org/en/projects/...

Pew Latin American Fellows

The Pew Latin American Fellows Program in the Biomedical Sciences provides support for young scientists from Latin America to receive postdoctoral training in the United States. The program gives thes...

pew.org

Pablo J. Sáez@pjsaez.bsky.social · 6mo ago

Very hot from the press ! Almost every topic we work in: #IonChannels #Leukocytes #CalciumSignaling T cell response depends on target-cell stifness to drive Piezo1- Orai1 membrane channels activation, softening of tumours prevents this response. Full www.science.org/doi/10.1126/... @science.org

T cell polarization and NFAT activation are stiffness dependent and differentially regulated by the channels PIEZO1 and ORAI1

Target stiffness influences T cell polarization and gene expression through distinct Ca2+ channels.

science.org

Science X / Phys.org@sciencex.bsky.social · 6mo ago

Activation of the Piezo1 ion channel in a mouse model of Alzheimer's disease restored brain blood flow and improved neurovascular function, suggesting potential for future therapeutic strategies. doi.org/hbnvgf

Preclinical study successfully reverses loss of blood flow to brain, an early sign of Alzheimer's disease

Supriya Chakraborty might have been studying insects in a lab had it not been for an immunology college instructor in India who taught him about the superheroes inside him—immune cells that wage a battle against bacteria, parasites, and a host of other adversaries that invade our bodies.

medicalxpress.com

Eric Mulhall@ericmulhall.bsky.social · 5mo ago

Very excited to share our new manuscript – published today! Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why. www.nature.com/articles/s41... An overview of the results below ⬇️ ⬇️

The molecular basis of force selectivity by PIEZO2 - Nature

PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

nature.com

Ardem Patapoutian@ardemp.bskyverified.social · 5mo ago

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...

The molecular basis of force selectivity by PIEZO2

Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

nature.com

Science X / Phys.org@sciencex.bsky.social · 8mo ago

Restoring levels of the phospholipid PIP₂ may help normalize brain blood flow and reduce symptoms in vascular dementia by regulating the activity of the Piezo1 protein.

Key phospholipid points to potential treatment for vascular dementia

A possible new treatment for impaired brain blood flow and related dementias is on the horizon. Research by scientists at the University of Vermont Robert Larner, M.D. College of Medicine provides novel insights into the mechanisms that regulate brain blood flow and highlights a potential therapeutic strategy to correct vascular dysfunction.

medicalxpress.com

@adamezracohen.bsky.social · 9mo ago

When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.

The Larner College of Medicine@uvmlarnermed.bsky.social · 9mo ago

#UVMLarnerMed research publication alert! #Brainresearch by authors Osama Harraz, Ph.D., and Ahmed Hashad, Ph.D., Department of Pharmacology, Larner College of Medicine, Vermont Center for Cardiovascular and Brain Health. @uvmvermont.bsky.social @apspublications.bsky.social

Osama Harraz@osamaharraz.bsky.social · 9mo ago

Excited to share the latest from our lab (final version, open access): Brain Capillary Ion Channels: Physiology and Channelopathies Physiology | @apspublications.bsky.social journals.physiology.org/doi/full/10.... @uvmlarnermed.bsky.social

Cordero-Vásquez Lab@cvlab.bsky.social · 9mo ago

Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6

Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome

Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...

jneurosci.org

Cordero-Vásquez Lab@cvlab.bsky.social · 10mo ago

The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2

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