Bianca M. Sacchi

@bmsacchi.bsky.social

Fond of genomes big and small 🌱🦠🧬 Currently: postdoc working on phylodynamics and genomic epidemiology @ Public Health Ontario Formerly: PhD in plant sex chromosome evolution @ U of T Opinions my own!

This isn't shortread data, but alignments of genome assemblies with N50 > 100Mb. The plot is the # of bp per 100Kb window that are dropped because of missing data -- because those bp physically are not there in one of the other 25 genomes. This is what normal plant genomes look like, folks.

Bild

It’s widely known (and, I think, pretty uncontroversial) that learning requires effort — specifically, if you don’t have to work at getting the knowledge, it won’t stick. Even if an LLM could be trusted to give you correct information 100% of the time, it would be an inferior method of learning it.

The Conversation U.S.@us.theconversation.com · 9mo ago

Relying on ChatGPT to teach you about a topic leaves you with shallower knowledge than Googling and reading about it, according to new research that compared what more than 10,000 people knew after using one method or the other. Shared by @gizmodo.com: buff.ly/yAAHtHq

Aaah! New preprint from the Sethuraman Lab has dropped! Tamsen and I have been working on this for a while, and we can’t wait for your feedback. Short thread on our swanky new polyploid genome simulator, DemographiKs, and its functionality.

bioRxiv Genomics@biorxiv-genomic.bsky.social · 9mo ago

Hidden in Plain Sight. How Ks histogram dynamics can reveal and obscure ancient whole genome duplications. https://www.biorxiv.org/content/10.1101/2025.11.19.689290v1

More really cool science news: Scientists have extracted the oldest known RNA! This is a particularly amazing feat because RNA degrades very quickly. (Also, we learned that Yuka here was a male, not a female as previously thought.) 🧪 (by @humbertobasilio.bsky.social for @sciam.bsky.social)

A Frozen Woolly Mammoth Reveals the World’s Oldest RNA

RNA has been extracted from an ancient woolly mammoth, providing insight into its last moments on Earth

scientificamerican.com

🚨 NEW: The majority holder of the world's genetic sequence data is a bad actor who can cut off access to critics and competing services. We've tolerated this for years, and now it threatens the pandemic treaty. Time for WHO to step in. With @ctrlalttim.com: www.thinkglobalhealth.org/article/to-f...

To Finish the Pandemic Agreement, WHO Needs a Trustworthy Viral Database | Think Global Health

Online platforms for sharing virus sequences are in disarray. The World Health Organization has a chance to build something new

thinkglobalhealth.org

probably my most deeply-held belief: it is not possible for a slide deck to be both (1) a good presentation aide; and (2) a standalone document that can be read and understood in isolation.