Anders Borgkvist
@borgkvistlab.bsky.social
Neurobiologist and basal ganglia specialist.
Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum https://www.biorxiv.org/content/10.64898/2026.05.08.723861v1
Preprint alert: We find that without DARPP-32 in the motor cortex, mice show impaired skill learning and, most strikingly, fail to form robust motor memories. Given DARPP-32’s enrichment in corticothalamic neurons, our findings reveal a causal role for the corticothalamic pathway in motor learning.
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 3mo agoDARPP-32 in motor cortex regulates structural and synaptic plasticity in corticothalamic neurons and enables motor learning. https://www.biorxiv.org/content/10.64898/2026.05.01.722248v1
Undergrad interested in 🧠 ? Join a webinar about our @stockholm-uni.bsky.social MSc program in Neurochemistry w/ Molecular Neurobiology (where I teach about circuits!) Wed Nov 19, 3 pm (start autumn 2026). stockholmuniversity.zoom.us/j/65851250648 Also: utbildning.su.se/english/educ... Pls repost!
Preprint alert: Striatal neurons in the eIF4-tg ASD mouse show dramatically increased activity-dependent plasticity. Unexpectedly, this is NMDA-dependent, not dopamine-driven. Excess protein synthesis alone can generate aberrant plasticity. www.biorxiv.org/content/10.6...
biorxiv.org
Happy to share this Spotlight article, drawing attention to recent work by @borgkvistlab.bsky.social on the mechanisms of dopamine action in the SNr. Read our summary and then read their paper! Many cool implications! @cp-trendsneuro.bsky.social www.cell.com/trends/neuro...
Dopamine’s secret agent: serotonin
Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent—instituting a high-...
cell.com
A study by @borgkvistlab.bsky.social published in Science Advances shows that dopamine modulates basal ganglia output not via DA receptors, but through serotonin and 5-HT1B activation. Findings in mice suggest a new mechanism relevant to #Parkinsons therapy. #Neuroscience 🧪 doi.org/10.1126/scia...
Dopamine and serotonin cotransmission filters striatonigral synaptic activity via 5-HT1B receptor activation
A monoaminergic high-pass filter regulates basal ganglia output activity.
doi.org
💊✨ Exciting new collaboration with Laurence Lafanechère’s team (Grenoble)! Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.
science.org
1/n. New paper from us: here we explore the mechanisms underlying maternal aggression in mice as a means of addressing how an individual transiently can gain access to a behaviour normally outside of its repertoire. Lead investigator Stefanos Stagkourakis (not on 🦋)🧵: www.nature.com/articles/s41...
Maternal aggression driven by the transient mobilisation of a dormant hormone-sensitive circuit - Nature Communications
Mothers can fiercely defend their young, but how the brain triggers this response remains to a large extent a mystery. Here, authors show that a dormant, hormone-sensitive brain circuit switches on to spark maternal aggression during the lactation period.
nature.com
Postdoc Opportunity at Karolinska Institutet: We're seeking an electrophysiologist to join an exciting collaborative project focusing on diabetes and Parkinson's disease. Join us! ki.varbi.com/what:job/job...
Postdoktor i Diabetes och Parkinsons sjukdom
Vill du bidra till medicinsk forskning av toppkvalitet? Det strategiska forskningsprogrammet för diabetes (SRP Diabetes) vid Karolinska Institutet finansierar ett prestigefyllt stipendieprogram för
ki.varbi.com
Happy to share this new paper from the lab in collaboration with George Augustine, characterizing synaptic connectivity between the claustrum and the anterior cingulate cortex. Congratulations to Roberto, Zach, and all co-authors. @robertodelator.bsky.social
Roberto de la Torre Martinez @robertodelator.bsky.social · last yr.Our new paper in Current Biology "Presynaptic and postsynaptic determinants of claustro-cortical connectivity" CLA→ACC projections are highly specific: defined by presynaptic identity, postsynaptic target, and cortical layer. Check here: www.sciencedirect.com/science/arti... #Neuroscience #Claustrum
Do you want to know how basal ganglia synaptic plasticity contribute to movement symtoms in PD? Can you achieve a giga seal? Good, then Join us! Please share. ki.varbi.com/se/what:job/...
Postdoctoral studies in Molecular and Synaptic Neurophysiology focusing on movement disorders (scholarship)
Do you want to contribute to top quality medical research? Join our dynamic and collaborative research team in Anders Borgkvist’s laboratory at the Department of Neuroscience, Karolinska Institute,
ki.varbi.com
🚨SAVE THE DATE‼️ Happy to announce that #DopamineMeeting2026 will be held in S E V I L L A🧠. May, 17-21, 2026
Excited to share our study on striatal dysfunctions in the eIF4E autism model! Understanding brain networks in ASD is key for targeted therapies. Huge thanks to PhD candidate Alina Aaltonen and our funders @Vetenskapsradet, @Wstiftelserna, @StratNeuro! www.biorxiv.org/content/10.1...
Postnatal reduction of eIF4E overexpression in D1-SPNs ameliorates KCNQ dysfunction, hyperexcitability and ASD-like behaviours.
An imbalance between the direct and indirect pathways of the striatum has been implicated in the pathophysiology of ASD, which corresponds with an increase in repetitive behaviours and hyperactivity. ...
biorxiv.org
What a fantastic Lucia performance by Biomedicum's own choir! The Lucia tradition marks the beginning of the darkest week of the year with only 5 hours of daylight in Stockholm. Heart-warming traditions like these are particularly important to maintain spirits high. @karolinskainst.bsky.social
Attend the Swebags conference on November 5th for exciting talks and posters covering the state-of-the-art in basal ganglia research. Entirely a remote event, which means that you can tune in from across the globe. Visit swebags.ebrains.se for event info and registration.
Home - SWEBAGS
Welcome to SWEBAGS The Swedish Basal Ganglia Society, SWEBAGS, is an non-profit scientific organization providing a platform for discussions and education opportunities in the area of basal ganglia re...
swebags.ebrains.se
Happy to finally see our paper published in Cell Reports. @cellpress.bsky.social Thanks to all the hard work put in by our team and to the funders of this study, including @vetenskapsradet.bsky.social Wallenberg stiftelserna, Ollebyggmästare, Åhlens’ and others. www.cell.com/cell-reports...
Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders
Basal ganglia dysfunction potentially causes behavioral alterations in ASD. Carbonell-Roig et al. show that the eIF4E Tg mouse model of ASD exhibits behavioral inflexibility and impaired striatal dopa...
cell.com
(“Hello World”); seems like an appropriate first post.