And a second new preprint from Lerner Lab on the same day! 👀 🎉 Led by graduate student Nkatha Mwenda! “Dopamine dips during unrewarded actions promote punishment-resistant reward seeking” #neuroskyence🧪

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2d ago

Dopamine dips during unrewarded actions promote punishment-resistant reward seeking https://www.biorxiv.org/content/10.64898/2026.08.01.742224v1

🚨Happy to share a new preprint from Lerner Lab led by graduate student @nadelneurosci.bsky.social! 🚨 “Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking” This has been a wholly impressive effort by Jacob; summary below 👇 #neuroskyence🧪

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2d ago

Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking https://www.biorxiv.org/content/10.64898/2026.07.29.741478v1

How does the brain represent the value of knowledge? In our paper--out now at Nature Neuroscience--we identify a representation of intrinsic information value within neural population structures in the orbitofrontal cortex in mice. www.nature.com/articles/s41593-026-02377-y #neuroskyence 🧠🧪 (1/8)

Representations of the intrinsic value of information in mouse orbitofrontal cortex - Nature Neuroscience

Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...

nature.com

Our new preprint from @daylab.bsky.social characterizes Chst9-MSNs, a specialized NAc population with high Oprm1 expression and opioid sensitivity that is required for fentanyl reward learning. Excited to share this work! 🧠🧬 www.biorxiv.org/content/10.6...

A very nice panel on translationally relevant studies of neural circuits for DBS this morning at #CRANIA2026 - covering thinking about Parkinson's, dystonia, and chronic pain. All star panel and really complementary talks! Gives me optimism in translating circuit work!

one.npr.org/i/nx-s1-5780...

🔊 Listen Now: As the Trump administration targets funding, scientists look beyond the U.S. to work

All Things Considered on NPR One | 4:19

one.npr.org

This is a great experience for early career folks! Working with the Intern and the Special Projects team are some of my best memories and highlight of my time as @npp-journal.bsky.social Social Media Editor!

Neuropsychopharmacology@npp-journal.bsky.social · last mo.

It's THAT time of year again: we have begun the search for our next NPP Editorial Intern🤩 The Intern works closely with NPP Principal Editors, Publishers, Special Projects Team & Social Media Editor + gets an invite to ACNP2027 Applications due July 30! More info: pmg.joynadmin.org/documents/10...

I've been told my discussion with NPR about US academics/scientists moving overseas will be on NPR later today on All Things Considered! Live broadcast 4-6pm Eastern. Don’t know when my segment will be within this, but tune in! Huge thanks to @npr.org for the opportunity to share my perspective.

I heard yesterday there are now over 12k comments. Great, but not enough! Comment, if you haven’t already.

Rebecca Saxe @rebeccasaxe.bsky.social · 2mo ago

The OMB has proposed rules that would, among other things, have political appointees override peer review and allow sudden grant termination. This morning I wrote a comment on this proposal in my own words. It only took a few minutes. You can do the same: www.regulations.gov/document/OMB...

I NEED YOUR ATTENTION. When violent and controlling people start to feel their power slip, they become more violent and controlling. I believe this is what’s happening in the Administration, now. This is a CRITICAL INFLECTION POINT: we MUST come together and push back *hard* NOW. 🧵 a thread

1/And just one more note: I have seen various science organizations begin to organize to comment on this rule. A: It is really important to comment on this rule. B: Why? A comment is part of the administrative record and the agency has to respond—in some way—to the comment.

Top story on the @nytimes.com app. A big sign that this all-important story is breaking into mainstream consciousness.

Local control of dopamine release in nucleus accumbens gates opioid withdrawal aversion https://www.biorxiv.org/content/10.64898/2026.05.25.727738v1

I followed these instructions to comment on the new proposed (disatrous) OMB rule - super helpful! Please take the time to write a specific, personal comment!!!

elizabethginexi.bsky.social@elizabethginexi.bsky.social · 2mo ago

Calling all Scientists! Research Administrators! Deans! Fans of Science! No one is coming to save us. Here is your assignment. I have written a step by step, easy to understand "how-to" document to help you comment on the proposed OMB rule. elizabethginexi.substack.com/p/what-we-ne...

Politicization of science is a pathway to mediocrity, decline, and real-world failure. The White House and OMB might want more power to undermine America's once-leading R&D ecosystem, but doing so comes with costs: to careers, discovery, the economy, our health, and national security.

Stand Up for Science!@standupforscience.net · 2mo ago

BREAKING: New proposed OMB regulation, applying to all federal grants, requiring grant reviews by senior political appointees and re-emphasizes that "peer review remains advisory and does not replace agency discretion". #standupforscience public-inspection.federalregister.gov/2026-10817.pdf

This is terrifying stuff

Drug Monkey@drugmonkey.bsky.social · 2mo ago

“agencies may consider an applicant’s history of questionable practices based on publicly available and verifiable information.” Potential perma bans for any University which ever supported any type of DEI activity.

I should have re-posted this a long time ago! 🤣 But please check out this interview I did with Sheena Josselyn at SickKids and #UofT. It was a great conversation!

ACNP@acnporg.bsky.social · 4mo ago

We are happy to share an interview with ACNP Member Fellow Sheena Josselyn, Ph.D. by Associate Member Talia Lerner, Ph.D. 🙂👉 tinyurl.com/yzxyd643 Talia Lerner

The Lerner Lab is excited for #Dopamine2026 next week! Make sure to check out these sessions and say hello 👋 @dopaminesociety.bsky.social

🚨Exiting new preprint from Lerner Lab postdoc AJ Miller-Hansen examining the thalamus as a physiological driver of local, acetylcholine-dependent dopamine release! 🚨 DA-ACh interactions have been 🔥but what’s really going on in vivo? We think we have some answers. #neuroskyence🧪

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 3mo ago

Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum https://www.biorxiv.org/content/10.64898/2026.05.08.723861v1

Posting for Vibhu Sahni: Due to unforeseen circumstances the Burke Neurological Institute will have to terminate its research operations 5/22. There are international postdocs on visas who are looking for new homes. Please reach out to Vibhu if you can help

I am looking for a new reserach technician. This is an entry level position ideal for a graudating senior. Please re-post and send candidates my way! zoemce@email.unc.edu

Check out the birghtest star in the room: PinkyCaMP - the latest member to the red GECI family! Amazing work led by Olivia Masseck and a wonderful team! Proud to contribute

Ryan Fink@finkryan.bsky.social · 3mo ago

PinkyCaMP is finally published!! My first paper co-first authored with @sikmys.bsky.social where we make a great optogenetic and multiplex compatible red calcium indicator. Thank you to @massecklab.bsky.social and @campbell-lab.bsky.social for guiding this journey www.nature.com/articles/s41...

This ruling, supported even by liberal justices, betrays a fundamental misunderstanding: Therapy is not the expression of a personal opinion - it's medical care. There is no first amendment right to medical malpractice.

The Associated Press@apnews.com · 4mo ago

BREAKING: The Supreme Court ruled against a law banning “conversion therapy” for LGBTQ+ kids in Colorado, one of about two dozen states that banned the discredited practice.

This piece reflecting on how I formed the ideas for my research was fun to write, and I hope you enjoy reading it!

The Transmitter @thetransmitter.bsky.social · 5mo ago

In our latest edition of “This paper changed my life,” @talialerner.bsky.social shares how Stephen Lammel and Rob Malenka’s 2011 Neuron paper on dopamine neuron diversity taught her how to go about challenging widely held assumptions in the field. www.thetransmitter.org/this-paper-c...

Burnt out, took the time she needed, came back with confidence, grace, and joy. An inspiration ✨🤩

Alex Ip 葉清霖@alexip718.com · 6mo ago

This photo by the AFP's Wang Zhao is everything right about figure skating

Watching the systematic dismantling of the world's largest funder of biomedical research is heartbreaking and infuriating

Max Kozlov@maxkozlov.bsky.social · 6mo ago

NEW: Another NIH institute director hasn't been renewed — the director of NIAMS (arthritis, musculoskeletal and skin diseases institute). That leaves a whopping 15 of 27 institutes and centers without a permanent director.

Get in, dorks. We're ready for round two. RALLY TO TAKE BACK SCIENCE! 🔬🧪✊ March 7th, 2026 in Washington, DC Learn more at www.standupforscience.net/ma... (link in our bio.)

Congrats to the new #GRCBasalGanglia vice-chairs! See you in Ventura, California 2028!

Happy to share this Spotlight article, drawing attention to recent work by @borgkvistlab.bsky.social on the mechanisms of dopamine action in the SNr. Read our summary and then read their paper! Many cool implications! @cp-trendsneuro.bsky.social www.cell.com/trends/neuro...

Dopamine’s secret agent: serotonin

Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent—instituting a high-...

cell.com

#GRCBasalGanglia co-chairs 4 life 🫶🏼