Thrilled to share Alessandro's beautiful work on a surprising novel presynaptic function of synuclein in dopaminergic neurons! 😎https://www.biorxiv.org/content/10.64898/2026.05.29.728874v1

Our latest collaboration with Guido and Cristina on mechanisms of BIPN! Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity - Iseppon - British Journal of Pharmacology - Wiley Online doi.org/10.1111/bph....

BPS Publications

This study compares the molecular mechanisms of chemotherapy-related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal th....

doi.org

🤔Can we translate microglial microtubules into therapeutic targets? You can read our take on it here! 👇👇👇https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1812417/full

Identification of a cytosol to nucleus feedback loop that regulates neuronal #microtubule nucleation. New study from Nitish Kumar, Melissa M. Rolls and colleagues (Pennsylvania State University): rupress.org/jcb/article/... #Neuroscience #Cytoskeleton

This is a huge, huge deal. Meanwhile the Director of the National Institute for Neurological Disease and Stroke (the agency that funds this kind of work) has been dismissed and the funding for disease research is being cut.

Dr. Keith R. Brunt@profbrunt.bsky.social · 7mo ago

Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!! 🧪🧠Cell www.cell.com/cell/fulltex...

Deadline Dec 5. Fellowships: Pancreatic Cancer Detection/AI—& more. Scadenza: 5 dicembre. Borse di ricerca sul Cancro al pancreas/intelligenza artificiale—e molto altro. @Columbia. Details: tinyurl.com/iafellow26 #PancreaticCancerAwarenessMonth, #WorldPancreaticCancerDay, #PancSky

Reliable actin labelling in expansion #microscopy 🔬 Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social Read the latest #preLight from @kanishka03.bsky.social ⬇️👀 prelights.biologists.com/highlights/h...

HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights

HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.

prelights.biologists.com

💊✨ Exciting new collaboration with Laurence Lafanechère’s team (Grenoble)! Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.

Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1... Soon at @spirochrome.com Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social

so many stories in one short clip!

Andy Moore@aaandmoore.bsky.social · 12mo ago

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

🚨 New Preprint! Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons. ▶️ www.biorxiv.org/content/10.1...

Nominate a deserving early-career investigator today for a chance to compete for a $100,000, 2-year grant! Support the next generation of Alzheimer’s researchers. Nominate ➡️ airtable.com/appjJE7FUGZY... #CCAD2026 #AlzheimersResearch #EarlyCareerScientists #ResearchFunding

LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data https://www.biorxiv.org/content/10.1101/2025.04.28.650893v1

Today, the 25th of April, in Italy 🇮🇹 we celebrate the #Liberation from NaziFascism. We celebrate to remember the people of the resistance, we celebrate to remember that we kicked fascists' asses once and we can do it again.

Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells. www.biorxiv.org/content/10.1...

Our PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️ #realtimemicroscopy

A blood test biomarker for early detection of Parkinson's disease when there are no symptoms @natureaging.bsky.social www.nature.com/articles/s43...

Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments - Nature Aging

Madrer et al. identify a Parkinson’s disease–specific increase in transfer RNA (tRNA) fragments in human blood, cerebrospinal fluid and postmortem brain tissue, demonstrating the ability of blood-base...

nature.com

Happy to share the latest paper of my postdoc JieJia Teoh from his old lab. Super lucky to have you join our MT family JJ! academic.oup.com/brain/advanc...

Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy

Gain-of-function variants in the GRIN2D gene cause a severe developmental and epileptic encephalopathy. Teoh et al. generate a mouse model with the V664I v

academic.oup.com

We have a new review out! In this Microscopy & Microanalysis piece, Louisa Mezache and I survey some of the latest commercially available microscope technologies: Nikon NSPARC, Re-scan Gaia, CSR Biotech MI-SIM, refinements to STED, SMLM from Bruker and Abbelight… Check it out with free access:

Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments

Abstract. Super-resolution microscopy techniques have accelerated scientific progress, enabling researchers to explore cellular structures and dynamics wit

academic.oup.com

Happy to share this fabulous collaboration with Laurence Lafanechere et al. in which we demonstrate that in addition to synergizing with taxanes, Carba1 remarkably protects neurons from CIPN by stimulating NAD biosynthesis through activation of NAMPT! www.biorxiv.org/content/10.1...

Preventing neuropathy and improving anti-cancer chemotherapy with a carbazole-based compound

Advances in cancer treatment have led to a steady increase in the rate of disease remission. However, while many treatment-related adverse effects gradually resolve after therapy, chemotherapy-induced...

biorxiv.org

Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...

Protein codes promote selective subcellular compartmentalization

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. In this study, we demonstrate t...

science.org

@michellemonje.bsky.social at @stanfordmedicine.bsky.social and Frank Winkler at Heidelberg University have won the 2025 @brainprize.bsky.social from the Lundbeck Foundation for their work in cancer neuroscience. By @sydneywyatt.bsky.social #neuroskyence www.thetransmitter.org/community/20...

2025 Brain Prize honors pair of cancer neuroscientists

Michelle Monje and Frank Winkler share the $1.4 million award for their discovery of synapses between brain cancer cells and neurons.

thetransmitter.org

Very interesting new cell biology linking the blood-borne hormone osteocalcin to the renewal of a primary cilia-autophagy axis in hippocampal neurons! rdcu.be/ebez3

A primary cilia–autophagy axis in hippocampal neurons is essential to maintain cognitive resilience

Nature Aging - Exploring the molecular mechanisms by which the blood-borne factor osteocalcin promotes cognitive resilience, Rivagorda, Romeo-Guitart et al. identify a primary cilia axis through...

rdcu.be

Your Action Is Needed! Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy www.ascb.org/science-poli...

Alzheimer's Association Research Fellowship (AARF) Alzheimer's Association Clinician Scientist Fellowship to Promote Diversity (AACSF-D) LOI deadline: Feb 27, 2025 Max Award: 200K-250K #medsky #academicsky 🧪 www.alz.org/research/for...

Cell Bio 2024 mini symposium on synaptic microtubules: every talk was engaging, thought-provoking, and left a great impression on everyone who attended. We've already received so much positive feedback! I love this bunch and can't wait to do this again!👇👇

Help choose JCB’s cover of the year! 🔬 Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. 🗓️ Voting closes on Friday, December 20! Have your say in celebrating the beauty of science 👉 https://buff.ly/3BdttSI #CellBio2024

I'm excited to share an invitation to the Science Art Show & Reception that Beata is organizing after her subgroup session. The event will take place near the conference venue directly after our subgroup (6:30-10:30 pm). Pls RSVP and join the fun!👇👇👇