#TWiNPP Why do some cannabis users never develop addiction while 1/10 progress to cannabis use disorder? A new genetic study reveals that cannabis use vs use disorder are wired differently: distinct brain networks, genes, and biology / @renatopolimanti.bsky.social www.nature.com/articles/s41...
Genetic pleiotropy differentially linking brain variation to cannabis use and cannabis use disorder - Neuropsychopharmacology
Neuropsychopharmacology - Genetic pleiotropy differentially linking brain variation to cannabis use and cannabis use disorder
nature.com
Using causal ML and data from ~90,000 NHS patients, we found that only 31% received the treatment the algorithm identified as optimal. Recovery rates were 11 percentage points higher among patients with the strongest recommendations who received their indicated treatment. lnkd.in/e5Muc4BJ
We've spent decades predicting who will "convert" to psychosis — while conversion rates keep falling and the people in our clinics keep struggling. Our new Viewpoint in JAMA Psychiatry makes the case: it's time to stop counting conversions.
With @remyfurrer.bsky.social, a new piece in Nature Human Behavior. The standard description of a polygenic score as a "genetic predisposition" essentializes a statistical construct. It's not language policing: PGS are a new kind of entity; now is the time to think carefully about what they are.
Polygenic risk scores are not genetic predispositions - Nature Human Behaviour
Nature Human Behaviour - Polygenic risk scores are not genetic predispositions
nature.com
Some evidence of decreasing depression rates among adolescents from the latest National Survey on Drug Use and Health. 60% of teens with depression reported receiving mental health treatment (31% taking meds) www.samhsa.gov/data/sites/d...
I am seeking motivated Postdoctoral and Postgraduate trainees to join our multidisciplinary team @yaleschoolofmed.bsky.social. We apply big data analytics to molecular, clinical, and imaging data to investigate human traits and diseases. www.nature.com/naturecareer...
Postdoc and Postgrad Positions in Computational Biology, Human Genetics, and Molecular Epidemiology - New Haven, Connecticut job with Yale University School of Medicine | 12858871
Postdoc and postgrad positions open in Dr. Renato Polimanti’s group at the Yale University School of Medicine.
nature.com
Our new paper, led by @renatopolimanti.bsky.social and I, and published today in Nature Genetics, is the largest multi-ancestry GWAS of endometriosis to date including 1.4 million women, 105,869 cases, six global ancestry groups. Previous studies were almost exclusively European.
Our lab (w/ @patrickgbissett) is hiring a full-time research coordinator to work with us on cognitive control, dense fMRI, computational modeling, and human-AI interaction. Designed for post-bacs looking to start a Ph. D in ~2 years. Please repost. phxc1b.rfer.us/STANFORDNLbWAG
Social Science Research Coordinator (Hybrid Opportunity) in School of Humanities and Sciences, Stanford, California, United States
Professor Russ Poldrack’s lab is seeking a new full-time Research Coordinator. The RC will work closely with and report directly to Dr. Patrick...
phxc1b.rfer.us
Anti-amyloid Alzheimer’s drugs show no clinically meaningful effect www.cochrane.org/about-us/new...
Anti-amyloid Alzheimer’s drugs show no clinically meaningful effect | Cochrane
cochrane.org
First paper led by me since joining BIDMC is out now! We identified a relationship between brain free water and cognition, and use that signature to cluster individuals with psychosis spectrum disorders into two stable clusters that differed clinically Link: authors.elsevier.com/c/1mnCd3AAzz...
NIH is requesting comments on a new draft policy that may require human brain imaging data (and other data) from nih-funded research to only be shared via controlled access, & only with certain countries. I suggest neuroimagers read closely & submit comments by 3/18. osp.od.nih.gov/comment-form...
Comment Form: Draft NIH Controlled-Access Data Policy and Proposed Revisions to NIH Genomic Data Sharing Policy
National Institutes of Health (NIH) Office of Science Policy (OSP): Request for Information on Draft NIH Controlled-Access Data Policy and Proposed Revisions to NIH Genomic Data Sharing Policy
osp.od.nih.gov
"The average Gen Xer lost about 6 points of IQ due to early childhood lead exposure, according to a study recently published in the Proceedings of the National Academies of Science." thewhyaxis.substack.com/p/the-leaded...
The leaded generation
More than half of Americans alive today were exposed to dangerous levels of lead as kids
thewhyaxis.substack.com
Both chambers of Congress have now passed the FY26 minibus with NIH provisions. The President will sign. (1) $48.7 billion for NIH (2) Full IDC recovery (3) No more multi-year funding (4) No NIH reorganization, maintaining the current IC structure.
This is good news for NIH-funded behavioral scientists and for the public; it resolves an unfortunate Catch-22 situation that inflated administrative burden and occasionally excluded basic behavioral science from funding opportunities: grants.nih.gov/grants/guide...
NOT-OD-26-032: Basic Experimental Studies in Humans (BESH) Will No Longer Be Considered Clinical Trials by the NIH
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Basic Experimental Studies in Humans (BESH) Will No Longer Be Considered Clinical Trials by the NIH NOT-OD-26-032. NIH
grants.nih.gov
Kansas just passed a monstrous bill enabling criminal penalties and vigilante lawsuits for trans people using the bathroom according to their gender identity and requires them to surrender their current drivers licenses and birth certificates if it does not match their sex assigned at birth.
He discussed autism/vaccines with Jay Bhattacharya on his show in June saying “If the data are robust that vaccines don’t cause autism, then run a proper trial” (those studies have been done) and discounted the idea that the rise in autism diagnoses can be explained by changes in testing/criteria.
In sum: all global prevalence rates about gaming addiction/disorder seem to be a partial combination of both gaming *and* gambling prevalence. The same applies to other studies, which use gaming measures in relevant languages. Chinese seems to be a major exception.
Oh, oh my. I need to go through this closely, and as noted earlier NN has a history. But my first read is wow www.nature.com/articles/s41...
Investigating the methodological foundation of lesion network mapping - Nature Neuroscience
The lesion network mapping method links diverse brain lesions to similar functional brain networks, reflecting general brain organization rather than disorder-specific circuits.
nature.com
Interested in research on depression in youth? New opening for a full-time research assistant in our lab (webbslab.com) to work on a range of projects focused on the causes & treatment of depression in teens. Come join our growing lab. Please RT and share! Apply⬇️ webbslab.com/job-postings
New preprint alert! We used connectome-based predictive modeling in a transdiagnostic sample to identify brain network correlates of wide array of behavioral measures. We also identify where networks supporting cognition overlap with those linked to diagnostically related clinical symptomatology.
Transdiagnostic connectome-based predictive modeling of many behavioral phenotypes reveals brain network mediators of clinical-cognitive relationships
Connectome-based predictive modeling (CPM) applied to functional MRI connectivity data can identify brain networks that vary with behavioral measures across subjects. The prediction strength also prov...
biorxiv.org
Toward Robust Neuroanatomical Normative Models: Influence of Sample Size and Covariates Distributions | bioRxiv www.biorxiv.org/content/10.1...
netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1101/2025... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging ⤵️
Survey study identifies that most patients with depression interpret the Patient Health Questionnaire instructions incorrectly, raising questions about its validity for clinical and research use. ja.ma/4s27WSt
Looking for a post-bac RA position focused on the brain bases of affective and psychotic illness? @holmeslab-bhi.bsky.social is hiring! @cahbir.bsky.social @rutgersbhi.bsky.social @rutgersu.bsky.social @sobp-org.bsky.social @hitop-system.bsky.social @ohbmofficial.bsky.social
Wow. Harvard nuking its PhD programs - Science PhD admissions reduced by more than 75% - Arts & Humanities reduced by about 60% - Social Sciences by 50–70% - History by 60% - Biology by 75% - The German department will lose all PhD seats - Sociology from six PhD students to zero
Harvard FAS Cuts Ph.D. Seats By More Than Half Across Next Two Admissions Cycles | News | The Harvard Crimson
The Faculty of Arts and Sciences slashed the number of Ph.D. student admissions slots for the Science division by more than 75 percent and for the Arts & Humanities division by about 60 percent for th...
thecrimson.com
www.nature.com/articles/s44...
A stratified precision medicine trial targeting α2A-adrenergic receptor agonism as a treatment for the cognitive biotype of depression - Nature Mental Health
This study demonstrates that guanfacine immediate release enhances cognitive control circuit function and behavioral performance in a neurobiologically defined cognitive biotype of depression, achievi...
nature.com
A method for capturing neuronal activity using fMRI excited the neuroimaging field but couldn’t be replicated. Today, the authors of the original paper retracted their work. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/retraction/a...
Authors retract Science paper on controversial fMRI method
Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.
thetransmitter.org