How does the brain represent the value of knowledge? In our paper--out now at Nature Neuroscience--we identify a representation of intrinsic information value within neural population structures in the orbitofrontal cortex in mice. www.nature.com/articles/s41593-026-02377-y #neuroskyence 🧠🧪 (1/8)

Representations of the intrinsic value of information in mouse orbitofrontal cortex - Nature Neuroscience

Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...

nature.com

Congrats Lorenzo and team! 👏 excited to collaborate with you in the near future!

Lorenzo Posani@lorenzoposani.com · 3w ago

Out today on @nature.com! Connecting neural specialization, population geometry, and their functional implications across the cortical hierarchy. So grateful for this beautiful and fun collaboration with @shuqiw.bsky.social, S Muscinelli, L Paninski, and @stefanofusi.bsky.social!

Hard to overstate the importance of this paper. Acategoricality and mixed selectivity together kill a lot of sacred cows. For starters, place cells aren't real, in that they are not a meaningful category. They are just a thing we scrape out of the data. Scientists focus on them because...

Columbia University's Zuckerman Institute@zuckermanbrain.bsky.social · 3w ago

Scientists have long debated whether neurons are jacks of all trades or tend to specialize in one thing. Now @stefanofusi.bsky.social, @lorenzoposani.com & Liam Paninski present new evidence in @nature.com shedding light on how the brain performs complex tasks. tinyurl.com/yj3ew8en

Our labs first paper! Some 😳 surprising effects. Turns out everything comes back to context 🤓

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 4w ago

Ventral tegmental area acetylcholine generates appetitive and aversive incentive motivation https://www.biorxiv.org/content/10.64898/2026.07.09.737546v1

I am happy to share our latest manuscript, led by newly-minted PhD Justin Wang, identifying a neural population that selectively controls hedonic, but not homeostatic, feeding. www.biorxiv.org/content/10.6...

Ventral pallidal GABAergic neurons control hedonic feeding and obesity

Food intake is governed by two interacting drives. The homeostatic hunger drive regulates food intake to fulfill caloric needs while the hedonic drive promotes intake of palatable foods outside of cal...

biorxiv.org

EXCITING PAPER! In this review, Drs. Parul Jain & Daniela Schiller synthesize research across various domains to trace how relationships develop from initial impressions through repeated interactions to stable social bonds & networks. Neuron l @cellpress.bsky.social 👉 www.cell.com/neuron/abstr...

Thank you! I’m honored to receive this award! A special thank you to Mount Sinai, my mentors, mentees, colleagues, and family!

The Friedman Brain Institute@sinaibrain.bsky.social · 2mo ago

🎉 CONGRATULATIONS to @brianmsweis.bsky.social for being honored w/ a well-deserved Faculty Council Junior Award. 👏 The Icahn School of Medicine @mountsinainyc.bsky.social’s Faculty Council Awards celebrate faculty members for their clinical excellence, academic leadership & outstanding research. 💯

📝 New preprint (co-led with Hannah Hamling as her NYU honors thesis!) 📝 🧠 Do adolescents learn differently in volatile versus stable environments? 🧠 Yes, and they seem to adapt their learning computations to a greater extent than adults! 😮 🤔 Preprint for deets (+ 👁️ data) osf.io/preprints/ps...

A few years back we started a collaboration to try to work out the mechanisms engaged by DBS for depression. Published today we found that it changes functional networks (expected) but also remodels specific white matter tracts (unexpected). Read more here: www.nature.com/articles/s41...

Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks - Nature Neuroscience

In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism through which this ...

nature.com

📣 Call for Applications: 2026 SRNDNA Pilot Grant We’re excited to announce the final round of SRNDNA pilot funding supporting research at the intersection of decision neuroscience & aging. 🗓️ Applications due June 1, 2026 🧠 Priority: ADRD-related projects #DecisionNeuroscience #AgingResearch #ADRD

Less than a week left! Apply now!

Decision & Aging@srndna.bsky.social · 4mo ago

📣 Call for Applications: 2026 SRNDNA Pilot Grant We’re excited to announce the final round of SRNDNA pilot funding supporting research at the intersection of decision neuroscience & aging. 🗓️ Applications due June 1, 2026 🧠 Priority: ADRD-related projects #DecisionNeuroscience #AgingResearch #ADRD

✨ April is #GraduateStudentAppreciation Month! 🏐 Highlighted here, Emma Andraka. Mentored by Daniela Schiller & @brianmsweis.bsky.social, Emma is developing a cross-species task for elucidating decision-making processes & neurophysiology underlying social interactions in rodents & humans. AMAZING!

Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...

Excited to share our recent review, which highlights algorithmic and implementational degeneracy in studies of cognition: www.sciencedirect.com/science/arti...

Addressing degeneracy in rodent studies of cognition

In order to relate neural dynamics to cognitive computations, it is critical to determine whether subjects are employing behavioral strategies that ac…

sciencedirect.com

Thank you @drnancypadilla.bsky.social for hosting me! I hope this can be a helpful resource for students considering if the MD/PhD path is right for them!

Stories of WiN@storiesofwin.bsky.social · 4mo ago

Thinking about pursuing an MD-PhD? In this special episode, we sit down with Dr. Brian Sweiss (@brianmsweis.bsky.social) to break down what you actually need to know about physician scientist training! 🎧 Full interview below! www.storiesofwin.org/profiles/202... #PhysicianScientist #MDPhD

Thank you @drnancypadilla.bsky.social for hosting me! I hope this can be a helpful resource for students considering if the MD/PhD path is right for them!

Nancy Padilla-Coreano@drnancypadilla.bsky.social · 4mo ago

Inspired by mentoring students who aspire MD-PhDs, I decide to interview @brianmsweis.bsky.social who is very passionate and knowledgeable about physician scientist education. If you are a trainee considering this path, or mentoring a trainee who is considering this path, please listen!!

Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...

Acetylcholine demixes heterogeneous dopamine signals for learning and moving

Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...

nature.com

🚨The Sweis Lab for Translational Neuroeconomics at Mount Sinai is searching for a postdoctoral research fellow! If you or someone you know is searching for a position, please share! 📄 📌Link to job flyer here: tinyurl.com/3vapfpn5 🧠 🐁 🔬🏙️🌆🧪🧬💊🧫💡🏥 @sinaibrain.bsky.social @mountsinai.bsky.social

For Pokémon’s 30th anniversary, Nature spoke to scientists from around the world about how their work has been shaped by playing Pokémon games, watching animated TV series and films and trading cards in school playgrounds. 🧪

Pokémon turns 30 — how the fictional pocket monsters shaped science

The Japanese media sensation has inspired generations of researchers in fields as diverse as evolution, biodiversity and research integrity.

go.nature.com

Congratulations to our 2026 Scholars! This year’s projects span molecules to circuits to behavior and reflect the highly collaborative environment that defines neuroscience at Mount Sinai. Sincere thanks to the donors whose support makes this type of curiosity-driven science possible.

The Friedman Brain Institute@sinaibrain.bsky.social · 6mo ago

A HUGE CONGRATULATIONS to the 2026 #FBIScholars Awardees! The FBI Scholars Award gives both young & established investigators the freedom & flexibility to explore the most audacious ideas in brain science. THANK YOU to our amazing donors w/o whom this award would not be possible!

The KM Lab is hiring! We're looking for both a new technician (makes a great post-bac like experience) and a post-doc. Come do fun science. Come join an amazing community. Learn more: sites.google.com/site/krookma...

We are recruiting! Postdoctoral research fellow at www.sdn-lab.org, studying the computational & neural basis of social decision-making. Birmingham is a fantastic & affordable place to live, with one of the youngest populations in Europe & over 600 parks. Please share! www.jobs.ac.uk/job/DQO275/p...

Postdoctoral Research Fellow in Social Decision Neuroscience at University of Birmingham

Explore an exciting academic career as a Postdoctoral Research Fellow in Social Decision Neuroscience. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

jobs.ac.uk

If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle rather than an afterthought, writes @suthanalab.bsky.social. #neuroskyence www.thetransmitter.org/animal-model...

Neuroscience has a species problem

If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle.

thetransmitter.org

Really important insight from @suthanalab.bsky.social. There seems to be lots of general agreement about the importance for cross-species analysis. But, in practice and in the trenches - there's a real divide on how to do it and how to implement it. Appreciate these conversations being raised!

The Transmitter @thetransmitter.bsky.social · 6mo ago

If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle rather than an afterthought, writes @suthanalab.bsky.social. #neuroskyence www.thetransmitter.org/animal-model...

How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠 Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉

Changyang Linghu@changyanglinghu.bsky.social · 6mo ago

Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...

🧠📢 New preprint alert Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵 #neuroskyence #compneurosky

(1/6) We have a new paper out in #eNeuro! How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆 Read more: www.eneuro.org/content/12/1...

1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social www.biorxiv.org/content/10.1...

Characterizing neuronal population geometry with AI equation discovery

The visual cortex contains millions of neurons, whose combined activity forms a population code representing visual stimuli. There is, however, a discrepancy between our understanding of this code at ...

biorxiv.org

🚨 Reminder: Applications for #OptoGRC2026 are now OPEN! Don’t miss your chance to join an incredible week of science, discovery, and connection with the brightest minds in optogenetics 💡🧠 Apply now for the best chance of acceptance: www.grc.org/optogenetic-...