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Yves Brun lab

@brunlabcaulo.bsky.social

We like to look at bacteria do the things they do. Université de Montréal.

142 Posts1860 Follower907 Folgt
Luiz Pedro Carvalho, PhD@luizcarvalholab.bsky.social · 4mo ago

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy? Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation. www.nature.com/articles/s41... (1 out of 3)

Activation of l-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis - Nature Communications

Here, the authors report metabolic activation as a potential antimicrobial strategy against Mycobacterium tuberculosis. They show that supra-physiological activation of L-histidine biosynthesis r...

nature.com

Yves Brun lab@brunlabcaulo.bsky.social · 4mo ago

Our paper on the in situ structure of the Tad pili machine is now published in mBio journals.asm.org/eprint/D9AT2... #microsky

In situ architecture of the Tad pilus machine in Caulobacter crescentus | mBio

Investigating the Tad pilus nanomachine in a genetically tractable, non-pathogenic organism like Caulobacter crescentus provides a powerful model for elucidating the architecture and functional dynamics of this widespread system. Insights gained from studying the Tad machinery can improve our understanding of related Tad pilus systems in pathogenic bacteria such as Aggregatibacter actinomycetemcomitans, where Tad pili are a key determinant of biofilm formation and chronic infection. Additionally, the remarkable functional diversity of Tad systems, ranging from surface sensing in C. crescentus to bacterial predation in Myxococcus xanthus, highlights their broad biological relevance. By revealing the in situ architecture of the Tad pilus biosynthetic machinery, this study advances our understanding of a major class of bacterial nanomachines and may thus provide structural insights that could inform the development of new therapeutic strategies targeting pilus-mediated virulence.

journals.asm.org

Yves Brun lab@brunlabcaulo.bsky.social · 9mo ago

Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky

Yves Brun lab@brunlabcaulo.bsky.social · 5mo ago

Working on a 🧵 Bacterial Tad pili extend and retract pili using a single motor ATPase with a unidirectional catalytic mechanism. We find that the Tad motor achieves bidirectionality by physical inversion; alternating which face of the ATPase toroid engages the IM platform complex. #microsky

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 5mo ago

Reversible biological motion with unidirectional catalysis through inversion of ATPase orientation https://www.biorxiv.org/content/10.64898/2026.02.24.707734v1

Yves Brun lab@brunlabcaulo.bsky.social · 6mo ago

Thank you for highlighting our paper on how septal PG hydrolysis licenses a second wave of PG transpeptidation during cell separation! www.nature.com/articles/s41.... I will do a thread when the page set version is out.

Cell wall hydrolysis promotes a second wave of transpeptidation to achieve cell separation following septation in Bacillus subtilis - Nature Communications

Cell division in many Gram-positive bacteria involves the synthesis of a peptidoglycan septum that is then hydrolyzed to facilitate cell separation. Here the authors show that, after septum formation,...

nature.com

Jörg Stülke@joergstuelke.bsky.social · 6mo ago

The #SubtiWiki paper of the month for February has been selected. Great work on the final phase of cell division. subtiwiki.uni-goettingen.de/wiki/index.p...

Erin Goley@goleylab.bsky.social · 6mo ago

Hey alpha aficionados - it's almost time for CauloCon 2026! This free, virtual meeting will feature talks from @brunlabcaulo.bsky.social @thanbichlerlab.bsky.social and @lamasonlab.bsky.social with opps for trainee talks. Register using the link below. 👇

Marie Delaby@mariedelaby.bsky.social · 6mo ago

CauloCon 2026 is coming! 🔬✨ March 3–5 (fully virtual + free). Keynotes by Yves Brun, Becky Lamason & Martin Thanbichler. Great chance for grad students & postdocs to present their work (work-in-progress welcome!). Submit an abstract by Sun Feb 8. Register + submit: www.caulocon.com

Yves Brun lab@brunlabcaulo.bsky.social · 7mo ago

Very excited to be part of the amazing Gr-ADI Consortium to accelerate the discovery of new antibiotics. #microsky nouvelles.umontreal.ca/en/article/2...

Major funding for the discovery of new antibiotics

A research team co-led by UdeM's Yves Brun has received a US$3.8-million grant from the Gates Foundation to develop drugs to fight Gram-negative bacteria.

nouvelles.umontreal.ca

Wellcome Trust@wellcometrust.bsky.social · 7mo ago

Today Gates Foundation, @novo-nordisk.bsky.social and Wellcome are announcing $60 million for 18 projects led by teams across 17 countries as part of the Gram-Negative Antibiotic Discovery Innovator to help researchers share data and accelerate the discovery of urgently needed antibiotics.