Medical study provides new insights on sepsis

Researchers develop innovative method to analyze immune cell response during severe infection

ucalgary.ca

Imaging Staphylococcus aureus biofilms in vivo reveals neutrophil exclusion by PNAG exopolysaccharide | mBio

The biofilm-associated exopolysaccharide PNAG is frequently expressed in Staphylococcus aureus clinical isolates but is often reduced during laboratory passage, with expression highly dependent on growth conditions. While in vitro analyses have revealed that PNAG is not a dominant matrix component, our intravital imaging of community-acquired methicillin-resistant S. aureus (CA-MRSA) skin infections demonstrates that PNAG is robustly produced in vivo and plays a central role in immune evasion. These findings highlight how PNAG function in tissue environments may be non-obvious in vitro and underscore the need for in vivo models to understand biofilm pathogenesis. By revealing PNAG as a key barrier to neutrophil-mediated clearance, this work positions PNAG and PNAG-targeting glycoside hydrolases as compelling therapeutic candidates for treating antibiotic-resistant S. aureus biofilm infections, a major cause of morbidity in both healthcare and community settings.

journals.asm.org

AI in scientific publishing: Slower, worse, and more expensive

There’s a saying in the management world, popularized by NASA administrator Daniel Goldin in the 1990s, that the goal of technological improvements is to make products faster, better, and cheaper. Alt...

science.org

'Cellular behavioromics' reveals how immune cells swarm during sepsis

Despite the best efforts of intensive care unit (ICU) staff and physicians and the most advanced life support, Dr. Bryan Yipp, witnesses many deaths in the ICU attributed to sepsis. "Sepsis is the bod...

medicalxpress.com

University of Calgary researchers invent a new way of looking at the cells inside our body

University of Calgary researchers invented a new way to analyze cells inside our body. The methodology coined Cellular Behavioromics has enhanced understanding of deadly sepsis infections. During seps...

eurekalert.org

Activation of the auricular vagus nerve reflex suppresses airway inflammation

Bioelectronic technologies are being deployed to treat many inflammatory conditions using transcutaneous auricular nerve stimulation. Shibuya et al. employ viral tracing, chemogenetics, and optogenetics to unveil a sensory skin-lung vagal reflex that suppresses allergic airway inflammation. They identify the neuropeptide CGRPβ as a key mediator and provide a rationale for transcutaneous bioelectronic neuromodulation in asthma.

dlvr.it

Right now, AI is making science publishing slower, worse, and more expensive

Not Faster, Better, Cheaper

science-forever.com

Activation of the auricular vagus nerve reflex suppresses airway inflammation

Bioelectronic technologies are being deployed to treat many inflammatory conditions using transcutaneous auricular nerve stimulation. Shibuya et al. employ viral tracing, chemogenetics, and optogeneti...

cell.com

Hyperinnervation inhibits organ-level regeneration in mammalian skin

Embryonic skin wounds regenerate diverse cell types across all lineages, but this capacity is lost soon after birth, as a postnatal wound-specific fibroblast population drives excessive innervation th...

cell.com

Neutrophil serine proteases degrade endothelial cortactin and promote extravasation

Guerrero-Fonseca et al. provide evidence for a cellular cross talk through which neutrophils transfer proteases into endothelial cells to degrade cortactin

rupress.org

Goblet cells tune ILC2 activity through a gut-specific response checkpoint

Notch signaling tunes the environmental responsiveness of intestinal ILC2s.

science.org

Protective and pathological roles of immunothrombosis in sepsis

Nature Reviews Immunology, Published online: 09 June 2026; doi:10.1038/s41577-026-01323-0A study in Science uses intravital microscopy to analyse the septic process in real time in mouse lung, showing that immunothrombus formation is associated with early pathology and mortality but later protection from disease through bacterial trapping.

dlvr.it

Protective and pathological roles of immunothrombosis in sepsis - Nature Reviews Immunology

A study in Science uses intravital microscopy to analyse the septic process in real time in mouse lung, showing that immunothrombus formation is associated with early pathology and mortality but later...

nature.com

doi.org

Aging restricts maturation of CXCL13+ T follicular helper cells in human immunity

A decline in specific antibody responses is a hallmark of human aging, yet the differential contributions of B and T lymphocytes remain unclear. CXCL1…

sciencedirect.com

Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice

Sepsis is an immune paradox in which host defense is necessary for survival but also contributes to organ damage and death. We defined an immunothrombosis cascade of neutrophil and platelets in the lu...

science.org

Skin inflammation and itch response are independently regulated by distinct nociceptor subsets

Using scRNA-seq of skin-innervating neurons, Voisin et al. show that skin-projecting nociceptor subpopulations differentially integrate the inflammatory response during allergic contact dermatitis. Although peptidergic TRPV1+ neurons control neutrophils and the inflammatory response, reprogrammed NP1 neurons control itch-evoked behavior.

dlvr.it

Wired for immunity: neuroimmune control of the lung by sensory neurons - Nature Reviews Neuroscience

Lung diseases drive substantial hospitalization, but available therapies remain limited. In this Review, Talbot and colleagues highlight pulmonary neuroimmunology — the bidirectional crosstalk between...

nature.com

Wired for immunity: neuroimmune control of the lung by sensory neurons - Nature Reviews Neuroscience

Lung diseases drive substantial hospitalization, but available therapies remain limited. In this Review, Talbot and colleagues highlight pulmonary neuroimmunology — the bidirectional crosstalk between...

nature.com

Calgary researchers call for national database tracking physician sexual assault, misconduct | CBC News

Researchers from the University of Calgary say they've found key gaps in the way allegations and findings of sexual assault and misconduct against physicians are tracked and reported in Canada — and t...

cbc.ca

Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma - Nature Medicine

Genomic and transcriptomic analysis of samples from patients with multiple myeloma, followed by in vitro validation, indicate mechanisms of antigen escape in response to GPRC5D T cell-engager talqueta...

nature.com

International study led by UCalgary explores why multiple myeloma patients often relapse after immunotherapy

Understanding how tumour cells build resistance to treatment may impact future individualized cancer care

ucalgary.ca

Skin inflammation and itch response are independently regulated by distinct nociceptor subsets

Using scRNA-seq of skin-innervating neurons, Voisin et al. show that skin-projecting nociceptor subpopulations differentially integrate the inflammatory response during allergic contact dermatitis. Al...

cell.com

The Rockefeller University » Symposium highlights SNFiRU's transition from incubator to engine

Three years in, the Stavros Niarchos Foundation Institute for Global Infectious Disease Research has matured into a working pipeline connecting basic science and emerging therapies.

bit.ly

Meet the winners of the 2026 Gairdner Awards

Annual prizes from a Canadian foundation recognize the most significant advances in human biology and medicine

theglobeandmail.com