Brian Sheridan Lab
@bsheridanlab.bsky.social
T Cells and Mucosal Immunology Assoc. Professor at Stony Brook University
We gave Jay Bhattacharya an opportunity to clarify his vaccine stance: does he REALLY believe that the vaccine is worse than the disease? Instead, he launched into a defense of MAHA as the future of scientific inquiry, and never really gave us a straight answer... @repauchincloss.bsky.social
Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. New study from Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues @ccii-kyoto.bsky.social: rupress.org/jem/article/... #TumorImmunology
Review: Reaching maturity: Thymic γδ T cell differentiation in mice and humans www.science.org/doi/10.1126/... @sciimmunology.bsky.social @bsilvasantos.bsky.social
Urs Mörbe, William Agace et al. characterize and spatially map the fibroblast landscape within human large and small intestinal gut-associated lymphoid tissues, including Peyer’s patches and isolated lymphoid follicles, during homeostasis and #Crohns disease. rupress.org/jem/article/... #IBD
Always worth repeating: Every new medicine begins in an academic lab, and this publicly funded research is one of the strongest economic engines a state can support, making the proposed EBRI a win-win for everyone, so sign and share >>> c.org/nDnRNSsVcq
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
Can you spare a minute to help this campaign?
c.org
Hey friends. I’m looking for a postdoc interested in studying host-pathogen interactions and immunology of tuberculosis. Send me some good people! We have a great group here! Email me joanne@pitt.edu. Thanks!
Wondering why you should ✍ our petition? c.org/nDnRNSsVcq In @aai.org, founder @drshrutinaik.bsky.social reveals why the coalition was formed, why NY needs a state-backed research institute, and how scientists should organize for systemic support — here and nationwide. news.aai.org/2025/11/20/n...
Immunologists Push for State Biomedical Research Funding in New York - AAI News
Dr. Shruti Naik is one of the immunologists in New York state behind NY-CURES, advocating for state investment in biomedical research.
news.aai.org
David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.
David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
Nature - The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.
nature.com
Key points on the need for continued animal use in scientific research. www.theguardian.com/science/2025...
Why we have to continue with animal testing for medical research | Letters
Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments
theguardian.com
Run a lab? Work in a lab? Wondering where your future research funding will come from? New York has an unprecedented opportunity on the table — a bold proposal to supercharge biomedical research and innovation across the state. 👉 Sign the petition & share to help make it happen.: c.org/TDMy2H9JTW
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
c.org
Online now: Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells
Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells
Mattingly et al. use human lung cells to show that virus-specific CD8+ tissue-resident memory T cells trigger epithelial antiviral defenses via IFNγ. This early protective response varies by epithelial subset, restricts influenza infection, and highlights the importance of Trm-epithelial cell crosstalk in mediating respiratory virus control.
dlvr.it
Excited to share our new paper in @jem.org! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (#Trm) amplify antiviral protection during reinfection. #immuno 🧵👇1/6
Journal of Experimental Medicine@jem.org · 9mo agoHernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/... #MucosalImmunology
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/47zrzYZ
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
go.nature.com
Enjoyed sharing my home brew 'Cyto-hops-ic IE-ale' with everyone at our departmental Oktoberfest. Unfortunately, only my lab and a select few understood the reference.
www.nejm.org/doi/10.1056/... Science is pretty amazing! The amount of basic science that leads to these clinical breakthroughs is staggering and often not appreciated by the politicians that decide funding levels
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...
nejm.org
A key US Senate committee has indicated that it will reject the huge budget cuts that President Donald Trump proposed for some science agencies, including the US National Science Foundation and NASA. go.nature.com/40H0XST
US senators poised to reject Trump’s proposed massive science cuts
Committee gives first hint that policymakers might preserve, rather than slash, funding for US National Science Foundation and other agencies.
go.nature.com
As NIH budget deliberations continue, prepare to hear Bhattacharya deflect substantial questions about the negative effects of his funding policies with “I’m an economist.” He’s not a very good one if he’s unable to assess the impact of funding decisions at the agency he directs.
Ferric Fang, MD@fangferric.bsky.social · last yr.BHATTACHARYA'S "FORWARD FUNDING" SCHEME In last week's Senate Appropriations hearing with the NIH Director, Bhattacharya and Sen. Baldwin clashed over the proposed scheme. Baldwin said it was "funny math," to which Bhattacharya responded, "I'm an economist." www.politico.com/newsletters/...
Our latest review on macrophages Macrophages: sentinels, warriors, and healers url:https://academic.oup.com/hmg/article-abstract/doi/10.1093/hmg/ddaf087/8158008 academic.oup.com/hmg/advance-...
Macrophages: sentinels, warriors, and healers
Abstract. Macrophages are versatile innate immune cells that act as sentinels, warriors, and healers in virtually every tissue. This review synthesizes cur
academic.oup.com
Listen to our newest Immunology faculty @priyadevarajan.bsky.social discussing her new lab @stonybrookmedicine.bsky.social and the benefit of @societymucosalimm.bsky.social mentorship program to her career development!
Mucosal Immunology@mucosalimmunol.bsky.social · last yr.Start your week off with the latest episode of the Mucosal Immunology Podcast @societymucosalimm.bsky.social featuring @priyadevarajan.bsky.social with @marionbrunck.bsky.social @ashu-mangalam.bsky.social and more: open.spotify.com/episode/3dJF...
These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years. It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
Proud of Harvard for pushing back, exercising some creativity, and, maybe, helping folks get some needed education. Harvard is making many of their online government courses FREE. I just signed up for "Citizen Politics in America". They even asked me my Gender. pll.harvard.edu/subject/gove...
Government | Harvard University
Browse the latest Government courses from Harvard University.
pll.harvard.edu
Metabolic reprogramming of IL-17 producing gd T cells promotes de novo lipogenesis under psoriasis conditions
γδ T cell Forum@forum-gd.bsky.social · last yr.Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions #gdTcells @natmetabolism.nature.com
NEW: We (mostly @noamross.net) launched a website to shine a brighter light on terminated NIH and NSF grants. grant-watch.us It links to our NIH & NSF trackers, grant info submission forms, and other info. We'll also add new analyses soon. Check it out and let us know what else you'd like to see.
Grant Watch
grant-watch.us
Check out this cool new study from a colleague at @stonybrookmedicine.bsky.social. Congrats to Charles and his team! Mtb-reactive CD8a expressing NK cells in humans!
Waggoner Lab@labwaggoner.bsky.social · last yr.CD8α marks a Mycobacterium tuberculosis-reactive human NK cell population with high activation potential www.nature.com/articles/s41...
Another great study from the @khannakm.bsky.social lab! Disease tolerance to limit Pathology in mucosal tissues
Kamal M Khanna@khannakm.bsky.social · last yr.Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful... our study out now in@cp-immunity.bsky.social #macrophages
Check out this fantastic story from @ikinglab.bsky.social group! There's always something cool going on in the mucosa
King Lab at McGill University@kinglabmcgill.bsky.social · last yr.I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators. www.sciencedirect.com/science/arti...
