Kamal M Khanna
@khannakm.bsky.social
Scientist/Immunologist at NYU school of Medicine. http://khannalab.weebly.com/kamal-m-khanna.html
2/ Our brand new Focus Issue brings together some of the latest research in trained immunity. Explore it all today 👇 elifesciences.org/collections/...
Focus Issue: Trained Immunity
Our latest Focus Issue looks at what we’ve learnt over the past decade and what’s next for the field of trained immunity.
elifesciences.org
1/ This Review Article from our new Focus Issue outlines how #epigenetic and metabolic rewiring enables innate immune cells to ‘remember’ past challenges, shaping protection, pathology, and new therapeutic strategies. buff.ly/NHdWyKS
Pleased to share our review l. Thank you @payalyokota.bsky.social
Payal Yokota@payalyokota.bsky.social · 9mo agoHappy Friday! We're so thrilled to share our review on #trainedimmunity out in @elife.bsky.social today. We had a great time writing this. Honored to be included in the special issue of trained immunity. Always an absolute treat to write with @khannakm.bsky.social elifesciences.org/articles/108...
Check out this beautiful paper from Isaac Chiu lab, with some contributions from our lab. www.science.org/doi/10.1126/... @khannakm.bsky.social
Vagal TRPV1+ sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics
TRPV1+ neurons facilitate host survival from flu infection by controlling viral spread, myeloid cell responses, and immunopathology.
science.org
Brilliant and paradigm shaking new story by Vishwa Deep Dixit's team out this month @naturemetabolism.bsky.social -"Cysteine depletion triggers adipose tissue thermogenesis and weight loss". Congratulations to Deep, Aileen and the entire team on this important work. 🤯 www.nature.com/articles/s42...
Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism
The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
nature.com
Check out the latest review article from #TeamKhanna superstars Eduardo Bernier and recent alumni Dr. Eric Bartnicki. Macrophages: sentinels, warriors, and healers Free Link: academic.oup.com/hmg/advance-... @khannakm.bsky.social
Our latest review on macrophages Macrophages: sentinels, warriors, and healers url:https://academic.oup.com/hmg/article-abstract/doi/10.1093/hmg/ddaf087/8158008 academic.oup.com/hmg/advance-...
Macrophages: sentinels, warriors, and healers
Abstract. Macrophages are versatile innate immune cells that act as sentinels, warriors, and healers in virtually every tissue. This review synthesizes cur
academic.oup.com
#WeAreWhatWeEat! #EveryCellIsAnImmuneCell! Dixit, Lee &co show @natmetabolism.nature.com that caloric restriction depletes cysteines, driving weight loss & browning of white adipose tissue via sympathetic nervous system-derived noradrenaline signaling, reversing metabolic inflammation in obese mice!
Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism
The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
doi.org
Thank you for highlighting this preview of our work by Drs. Rothlin and Ghosh at @yalesph.bsky.social. What a delight to see this.. 🥹 @khannakm.bsky.social @yeungadventures.bsky.social
Waggoner Lab@labwaggoner.bsky.social · last yr.Lung nerve- and airway-associated macrophage response to type I interferon limits SARS-CoV-2 spread, inflammation, lung injury, and mortality @cp-immunity.bsky.social preview cell.com/immunity/ful... of cell.com/immunity/ful...
May issue is online! Explore reviews on the #neuroimmune axis! The beautiful cover was designed by Ella Marushchenko, working with @jonykipnis.bsky.social. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...
🫁"Lung Immune Cell Type ‘Quietly’ Controls Inflammation in COVID-19". Congrats @payalyokota.bsky.social, @khannakm.bsky.social, and colleagues! nyulangone.org/news/lung-im...
Lung Immune Cell Type ‘Quietly’ Controls Inflammation in COVID-19
NYU Langone study shows a type of immune cell in the lungs may help prevent inflammation from spiraling out of control during COVID-19. Learn more.
nyulangone.org
www.cbsnews.com/news/scienti... I wish this was sensationalized or exaggerated - but the impact on US biomedical research outlined in this report is, unfortunately, very much real.
Scientists fear Trump administration cuts to NIH could impact the health of Americans for generations
Former National Institutes of Health Director Dr. Francis Collins, who abruptly left his NIH research lab in February, fears aggressive downsizing could impact Americans' health.
cbsnews.com
Please watch tonight’s important episode of “60 minutes” focused on the impacts of reductions to the NIH budget and workforce featuring a UW Immunology graduate student. www.youtube.com/watch?v=noyS...
NIH | Sunday on 60 Minutes
YouTube video by 60 Minutes
youtube.com
Fantastic and important work @ikinglab.bsky.social
King Lab at McGill University@kinglabmcgill.bsky.social · last yr.I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators. www.sciencedirect.com/science/arti...
Another great study from the @khannakm.bsky.social lab! Disease tolerance to limit Pathology in mucosal tissues
Kamal M Khanna@khannakm.bsky.social · last yr.Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful... our study out now in@cp-immunity.bsky.social #macrophages
Host defense involves both resistance and disease tolerance, a concept elegantly demonstrated in lung viral infection by @yeungadventures.bsky.social @payalyokota.bsky.social @khannakm.bsky.social and colleagues. Spread the word!!
So cool! Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...
cell.com
Online now: Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated macrophages (NAMs) in mitigating SARS-CoV-2 pathogenesis. NAMs regulate viral spread and inflammation through type I interferon signaling, revealing their critical function in disease tolerance and potential as therapeutic targets for respiratory viral infections.
dlvr.it
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful... our study out now in@cp-immunity.bsky.social #macrophages
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...
cell.com
Excited to share our latest study @cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social for his outstanding mentorship throughout! Pls read/share!👇 www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...
cell.com