📢 #Postdoc job: I am looking for a #bioinformatician to join my lab for investigating #XchromosomeInactivation and #chromatin-mediated #epigenetic mechanisms underlying #sexbias in #MultipleSclerosis. Please RT

We are looking for someone to lead the new Facility for Protein Biochemistry & Biophysics at the MPI of Immunobiology and Epigenetics in Freiburg — please spread the word and apply if you are interested!

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · last mo.

🚀 Job alert: We’re starting a new Facility – and you can lead it! The MPI-IE & @mariekeoudelaar.bsky.social are hiring a Head of Protein Biochemistry & Biophysics to launch and lead a brand-new Core Facility in Freiburg 🇩🇪. Once-in-lifetime-chance. Details ⬇️ jobs.ie-freiburg.mpg.de/jobposting/b...

For the first time, we can see individual mRNAs in 3D inside cells at nm precision. Their shapes vary by gene and subcellular location. Congrats @fbzt.bsky.social & team @impvienna.bsky.social Top 1% @qedscience.bsky.social Edited by @lifescienceeditors.bsky.social www.biorxiv.org/content/10.6...

Super-resolved imaging of mRNA ultrastructure in cells

Messenger RNA (mRNA) is a central polymer of gene expression, whose ultrastructure and defining regulatory rules remain unclear. To visualize the ultrastructure of mRNA, we here develop Combi-PAINT, a...

biorxiv.org

For the second time this month, a team of researchers has reported harnessing a precise gene-editing technique to alter the DNA of human embryos go.nature.com/4vwIXrO

‘Edited’ human embryos reveal secrets of our development — and fuel ethical debate

Ethical discussions are urgently needed as genome-editing science advances, some researchers say.

go.nature.com

#postdoc #fellowship available in my lab (1year renewable) to investigate #chromatin mediated #epigenetic mechanisms of #sexbias in #autoimmunity and the role of long #mcRNA #XIST. Please RT!

📖 The final version of our paper is out in press Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption authors.elsevier.com/a/1m%7EU03vV... or www.cell.com/molecular-ce...

Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption

Shah, Tortora, et al. show that cells can dial the rate of cohesin loop extrusion by balancing the relative dosage of NIPBL and PDS5. Their models provide a quantitative mechanistic basis for the gene...

cell.com

Elphege Nora Lab at UCSF@elphegenoralab.bsky.social · 12mo ago

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

This a very important, and extremely well-executed study from Ralph Grand’s group @uniheidelberg.bsky.social. Congrats to all the authors! www.biorxiv.org/content/10.6...

Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes

A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to. spklr.io/63324EJmf0

Person functionally cured of HIV after bone marrow transplant from sibling

A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to

spklr.io

Our paper on the evolution of XIST regulatory network in primates is now published in Science Advances! Check out the paper www.science.org/doi/10.1126/... or a digest of our findings emmanuelczt.github.io/posts/2026/0... A short 🧵 of our main findings 👇

Remodeling of XIST regulatory landscape during primate evolution

How gene regulation strategies rapidly evolve across short evolutionary timescales is explored.

science.org

Last few days to apply for this #PhD project!

Duncan Sproul@sproullab.bsky.social · 8mo ago

🚨 Want to do a #Phd using high-throughput mutagenesis and CRISPR screens to understand how gene body methylation impacts transcription in collaboration with Greg Kudla's group? Do apply, deadline in a week! www.findaphd.com/phds/project... Deadline 15th December 2025 #epigenetics Please share 🙏

Australia recorded ZERO cases of cervical cancer in women under 25 for the first time since they started tracking the cancer in the 80s. This is the power of vaccines. The HPV vaccine is extremely effective at preventing cancer. Viruses can be oncogenic. Get your vaccines and protect yourself!

newsGP - Australia set for world-first cervical cancer elimination

Vaccination programs have played a key role, and GPs remain ‘instrumental’ in boosting screening rates to reach the 2035 target.

www1.racgp.org.au

🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease? Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city. 🧵 1/4 Please repost 🙏

Only 6 days left to apply! We’re recruiting a PhD student to study the immunogenic roles of transposable elements in pediatric AML. The project involves working with clinical trial samples in collaboration with Dr. Richard Dillon (KCL). If interested, get in touch!

Transposon and Cancer Epigenetics Group@deniz-lab.bsky.social · 10mo ago

Come and join us to discover immunogenic potential of transposable elements in pediatric AML as part of CRUK CoL PhD programme.

Advice needed: can you distinguish splicing variants by commercial #spatialtranscriptomic (eg visium)? #singlecell #omics

The #Nobel prize has been assigned to the discovery of #Treg peripheral tolerance. We are humbly greatful for this discovery as we recently described a subtype of Tregs associated with worse breast cancer prognosis

Irene Cantone@cantoneirene.bsky.social · 2y ago

Our first #immunology paper is out! We show that Tregs with FOXP3 splicing variants retaining exon 2 are a prognostic marker for breast cancer www.science.org/doi/10.1126/...

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism https://www.biorxiv.org/content/10.1101/2025.10.07.680990v1

How does a “universal” transcription factor evolve to do species-specific jobs? Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes. Read it here 👉 www.biorxiv.org/content/10.1... #MolecularEvolution #Transcription

Molecular determinants underlying functional divergence of TBP homologs

The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

biorxiv.org

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...

#Xcromosome paper on the role of the #human specific long noncoding RNA #XACT!

bioRxivpreprint@biorxivpreprint.bsky.social · 10mo ago

Upregulation of the lncRNA XACT sustains pluripotency, blocks lineage specification, and drives germ cell tumor-like transcriptional programs in human pluripotent stem cells https://www.biorxiv.org/content/10.1101/2025.10.02.679492v1

Chromatin is a long-range force generator that regulates plasma membrane tension and cell integrity independently of gene expression https://www.biorxiv.org/content/10.1101/2025.10.02.680155v1

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

❓Can a father’s environmental exposures before conception influence their offspring? We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences www.embopress.org/doi/full/10....

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal

imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

embopress.org

Metabolism changes the epigenome across generations via lysosome Supercool! www.science.org/doi/10.1126/...

Lysosomes signal through the epigenome to regulate longevity across generations

The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

science.org

To the #XchromosomeInactivation field: anyone knows Xist is a long #noncodingRNA Which publication has ruled out that there are protein coding regions within it? And how?

#Postdoc openings: we investigate #chromatin mediated #epigenetic mechanisms underlying #sexdifferences and #sexbias in #human #diseases including #immune and #cancer. If u want to join us, we can help you preparing #HFSP #EMBO #MarieCurie fellowships. DM or email (publications needed!)

The story of sex determination from a woman’s life perspective. Beautiful thread for #WomenInternationalDay

Mark A. Hanson@hansonmark.bsky.social · last yr.

This #InternationalWomensDay I want to tell the story of Lilian Vaughan Morgan. I learned of Lilian this past year - what a badass. Lilian was a leading scientist when women weren't welcome in the lab, nor even the department. But she contributed immensely to the genetics of sex determination 1/n

One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social

A #computational #Postdoc position is available in my lab to dive into #chromatin mediated #epigenetic mechanisms underlying #autoimmune reactions in #MultipleSclerosis! Please circulate