Happy to finally see this out in a peer-reviewed form 🧬🌱 Congrats to everyone who contributed! www.nature.com/articles/s41...

The dual trxG/PcG protein ULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions - Nature Plants

This study reports a bivalent factor, ULTRAPETALA1, that can counteract as well as promote PRC2 activity at hundreds of developmental genes in Arabidopsis thaliana. The pro-PRC2 activity of ULTRAPETAL...

nature.com

Our new study shows a CHD-family remodeler can nucleate and spread H3K9 methylation de novo, inverting the canonical hierarchy between writers and remodelers. www.biorxiv.org/content/10.6...

Nucleosome remodeling by a CHD enzyme promotes H3K9 methylation establishment and spreading via remodeler-writer feedback

In Schizosaccharomyces pombe , the conserved CHD remodeler Mit1 function within the SHREC remodeler-deacetylase complex (a homolog of the metazoan Mi-2/NuRD complex), which is essential for H3K9 methy...

biorxiv.org

We have a postdoc position available in the lab and would like to spread the word. Please apply if you are interested! www.cam.ac.uk/jobs/researc...

I feel it's not merely being anti-AI; it's also that many people work off the assumption that AI is (and will stay) in the "incapable and harmful" quadrant (below), leading them to neglect the risks in the "capable and harmful" quadrant (which are pretty concerning imo, but hard to discuss here).

I have a pet theory about bluesky: there's actually a silent majority of people with concern, but ultimately a nuanced opinion on AI. But this crowd is generally too hesitant to express any excitement or wonder bc there will be a hard-and-fast backlash from the vocal anti-AI contingent. Kinda sucks

Read this article, get excited, and come to the Epigenome Editing symposium! Marianne Rots, Charlie Gersbach, and Angelo Lombardo (all featured in the piece) will be there in person!! Registration only 50€, talks from abstracts, plus Paris 😜 @natureportfolio.nature.com www.nature.com/articles/d41...

Epigenetic editing makes its mark

Researchers are rewriting the chemical tags on DNA and chromatin to tune gene expression.

nature.com

Maxim Greenberg@maxvcg.bsky.social · 5mo ago

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

Sailing in @biorxivpreprint.bsky.social ready for summer, our study on the iconic Portuguese man o' war 🪼 is out: www.biorxiv.org/content/10.6.... We use (epi)genomics to understand a critter that fascinates me since childhood. Massive team effort with @obog.bsky.social, Cummins and Neely groups. 🧵

Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com Led by @crisnava.bsky.social and @seanamontgomery.bsky.social www.nature.com/articles/s41... Some highlights below

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n

I wish I was still blissfully unaware of the imminent toxic caterpillar takeover of Europe.... www.newyorker.com/science/elem...

How to Survive an Infestation of Toxic Caterpillars

The oak processionary caterpillar, which is spreading as Europe warms, fills the air with microscopic hairs that inflict excruciating rashes.

newyorker.com

That’s a beautiful story that shows again how powerful long reads are for studying transposable elements. Exciting times! For accessing the Perspective piece without a paywall: www.science.org/eprint/NIKHD...

Why the X chromosome is rich in L1 mobile elements

Preferential insertion into the late-replicating inactive X explains L1 accumulation in this chromosome

science.org

Our study published today @science.org shows that X-chromosome inactivation (XCI) attracts L1 mutations to the human X chromosome: doi.org/10.1126/scie... With outstanding Perspective from @aurelien-doucet.bsky.social & @retrogenomics.bsky.social: doi.org/10.1126/scie...

New preprint from Shendure Lab on Locus-Scale aka Long-@$$ MPRAs led by the amazing Abby McGee & @carinabiar.bsky.social Most MPRAs test ~300 bp fragments next to a promoter. But real enhancers are bigger, act combinatorially and from a distance. 1/n www.biorxiv.org/content/10.6...

Open position in our lab for a research engineer. The applicant must hold a PhD in life sciences and have demonstrable experience in molecular biology and biochemistry. For more info: emploi.cnrs.fr/Offres/CDD/U...

Institut Jacques Monod@ijmonod.bsky.social · 6d ago

#JobOffer 💼 Research Engineer (M/F) 📆 October 15th 📍Institut Jacques Monod, @sandraduharcourt.bsky.social 🔗 emploi.cnrs.fr/Offres/CDD/U...

Thank you @natgenet.nature.com for this nice Research Briefing www.nature.com/articles/s41... on our recent paper reporting live-cell measurements of Sox2 promoter bursting kinetics when varying its genomic distance from the SCR enhancer 👉 www.nature.com/articles/s41...

The genomic position of an enhancer modulates bursting dynamics of the cognate promoter - Nature Genetics

We show that, in a genomic locus with minimal complexity, the distance between promoter and enhancer modulates the frequency of clustered transcriptional bursts. Thus, besides the nucleotide sequence,...

nature.com

Next summer's Epigenetics GRC (I'm co-chairing with Deborah Bouch'is) is shaping up nicely with an all-star lineup of speakers working on a broad range of organisms and systems and everything from molecular mechanisms to new phenomena. Apply and put it on your calendar! www.grc.org/epigenetics-...

💫Don't miss the N&V by Priscillia Lhoumaud & @maxvcg.bsky.social 📰SUMOylation fine-tunes DNMT1 to silence viral mimicry transcripts. ⬇️ www.nature.com/articles/s41...

SUMOylation fine-tunes DNMT1 to silence viral mimicry transcripts - Nature Genetics

DNMT1 binds unmethylated CpG islands at active genes and, upon catalytic inhibition, redistributes to partially methylated, inaccessible regions, triggering viral mimicry via endogenous retroelements ...

nature.com

Preprint alert! 🚨 We are very excited to share our new manuscript on Bohring-Opitz syndrome, a devastating rare monogenic disorder driven by truncating variants in ASXL1. This project was led by PhD student Emma Doyle, one of the OG Conway lab members 💪. 1/6 www.biorxiv.org/content/10.6...

Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin

The PR-DUB complex is responsible for erasing the repressive histone modification, H2AK119ub1. ASXL1-3 proteins are mutually exclusive catalytic partners of BAP1 in the PR-DUB complex. Somatic heteroz...

biorxiv.org

Priscillia Lhoumaud and I were very happy to write a N&V for a monster paper about intriguing DNMT1 biology by @mafdawson.bsky.social and co, just out in @natgenet.nature.com . Check it out here (and the actual paper in the next post) (1/2) www.nature.com/articles/s41...

SUMOylation fine-tunes DNMT1 to silence viral mimicry transcripts - Nature Genetics

DNMT1 binds unmethylated CpG islands at active genes and, upon catalytic inhibition, redistributes to partially methylated, inaccessible regions, triggering viral mimicry via endogenous retroelements ...

nature.com

I don’t have an opinion about the piece in Science or the explanation of the use of ChatGPT as a search engine but I think the way people piled on the Editor-in-Chief of the Science journals is really shitty and will likely mean he’ll stop posting here when we could really benefit from his presence.

In preprints – housekeeping the housekeeping genes Maxim V. C. Greenberg @maxvcg.bsky.social writes about two complementary preprints by the @grandlab.bsky.social & @schubelerlab.bsky.social labs that elucidate the mechanistic framework of essential gene expression. doi.org/10.1242/dev....

In preprints – housekeeping the housekeeping genes

The term ‘housekeeping gene’ evokes a sense of banality. These are the boring genes that hum in the background, impervious to cell state or stress. For a developmental biologist captivated by the…

doi.org

Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/

An encyclopedia of human enhancer–gene regulatory interactions - Nature

An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...

nature.com

@mileshuseyin.bsky.social and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region-Capture Micro-C in @natprot.nature.com : www.nature.com/articles/s41... See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/M...

Nature Protocols@natprot.nature.com · 3w ago

New Article! Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC)

There is still time to register for this great free meeting itbcrde.inserm.fr/index.php?pa... Exciting speaker line-up and lots of slot for short talk. Please submit your abstract by July 20, 2026 It will be in the Grand Amphi, 102 Rue de la santé 75014 Paris, on September 21-22, 2026

Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41...

1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature Genetics

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...

nature.com

Si les nouvelles règles de l'éligibilité de l'ANR sont bien réelles, alors je ne comprends pas quelle est la logique sous jacente. Au vu de la pyramide des ages, forcer une collaboration avec chercheurs(ses) <10 ans post thèse va de facto exclure 80% des candidats.

This is brilliant! www.nature.com/articles/s41...

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature Genetics

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...

nature.com

I'll be hanging about The Company of Biologists' booth this afternoon together with two excellent academic editors for Development and Biology Open. If you have any questions about publishing in our journals, please make a visit #ISSCR2026

The Company of Biologists@biologists.bsky.social · 4w ago

Do come and say hello to our Editors today. They will be happy to answer any questions you have about publishing in our journals @amjeve.uk @tristanrodriguez72.bsky.social @irenemiguel-aliaga.bsky.social @dev-journal.bsky.social @biologyopen.bsky.social @dmmjournal.bsky.social

New preprint 📢 Thrilled to share our long-awaited work on the role of RSX in marsupial X-inactivation. This was a huge team effort over the years, led by @aureliencourtois.bsky.social @sermenchero.bsky.social Sugako Ogushi and Waz Varsally, that allowed us to set up genome editing in opossum embryos

Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation

X-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials. The lncRNA Xist mediates X-inactivation in eutherians but is absent from marsupials. An evolutionarily ...

biorxiv.org