We couldn't be more excited for the start of the 2026 UCSC RNA futures meeting. It's going to be a fun week!!#RNAFutures2026. share.google/4CYqqExEx69i...
CarpenterLab
@carpenterlab.bsky.social
LncRNA, innate immunity, macrophages
I was inspired by this story of a PhD student who retracted her paper because she found a critical coding error. This is the right thing to do, but it takes courage. She won the Ctrl Z Award celebrating scientists who discover errors and correct the record. www.science.org/content/arti...
ScienceAdviser Exclusive: Meet the inaugural winners of the Ctrl Z Award
Today in Science and science: Ice age hunters’ penchant for female mammoths, a detailed vagal map, and more
science.org
“Doctors hoped to repair that… It would be a clinical trial of one, funded in part by $860,000 the parents had scraped together from their own savings and from relatives.” The girl died a week after receiving the experimental treatment. Then her story was hidden. www.science.org/content/arti...
Exclusive: Death of girl in Chinese gene-editing trial was never made public
Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals
science.org
My quote of the day Beware of false knowledge; it is more dangerous than ignorance. George Bernard Shaw
Direct link for podcast with my friend and colleague Derek Angus at JAMA. jamanetwork.com/journals/jam... Derek was the PI of the first clinical trial that NIGMS ever funded (that is how I first met him). Testing a new alternative for protocolized treatment of early septic shock.
Why and How Should the Government Fund Biomedical Research?
Government funding for biomedical research is the topic of this Healthy Dialogue conversation between JAMA Senior Editor Derek C. Angus, MD, MPH, and Jeremy Berg, PhD, former editor in chief of Scienc...
jamanetwork.com
one example? using she to refer to the hypothetical scientist who will be helped by this new "vision" of American science 😭 I CANNOT EVEN 😫
There is still time to register to attend our present a poster at this year's UCSC RNA futures meeting. Registration closes tomorrow July 15th. share.google/uMnnkvcdMaC9...
RNA Futures Meeting – UCSC RNA Center
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107,000 comment so far. Make your voice heard.
Maureen Barr@barrlab.bsky.social · 2mo agoPosted my comments opposing OMBs proposed rule. It was so easy, using this great letter writing tool of @faseborg.bsky.social www.faseb.org/science-poli... Did you submit yours yet? The deadline is soon - July 13. This is essential to save science and research in the US.
Please join us in sunny Santa Cruz this August for the first RNA futures conference. Abstracts for awards and talk opportunities are due July 1st. Registration for trainees is just $500! RNA Futures Meeting – UCSC RNA Center share.google/4CYqqExEx69i...
RNA Futures Meeting – UCSC RNA Center
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“NIH’s plan identifies no innovation. ‘Gold standard science’ is a set of normative aspirations, not a manualized intervention with developers whose intent could be operationalized...It is a case study in how bureaucratic documents can be constructed to look serious while committing to nothing.”
elizabethginexi.bsky.social@elizabethginexi.bsky.social · 4mo agoI spent 22 years as an NIH Program Officer. When I read the "evaluation strategy" in NIH's Gold Standard Science implementation plan, I laughed out loud. Here's the case for why it was never a real plan. elizabethginexi.substack.com/p/evaluation...
Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.
Igor Ulitsky@igorulitsky.bsky.social · 10mo agoA preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Really annoying that viruses figured out the value of long noncoding RNAs too. www.cell.com/molecular-ce...
A cytomegalovirus-encoded lncRNA blocks cell-cycle progression
Human cytomegalovirus expresses the highly abundant lncRNA RNA2.7 to reprogram host gene expression. RNA2.7 stabilizes cellular mRNAs by sequestering RNA-binding proteins and enforces a G1-S cell-cycl...
cell.com
Gotta love San Francisco folks showing up in Ocean Beach for No Kings! Awesome! 🔥
“The Long Labor,” a short documentary that follows Watsonville midwife Maria Ramos Bracamontes, is part of the Watsonville Film Festival’s program this year. Lookout spoke with the film’s co-director Consuelo Alba, who also founded the festival.
Documentary showcasing work of local midwife to screen at Watsonville Film Festival next week
“The Long Labor,” a short documentary that follows Watsonville midwife Maria Ramos Bracamontes, is part of the Watsonville Film Festival’s program this year. Lookout spoke with the film’s co-director…
buff.ly
This is why it's not enough for Congress to just appropriate funds to scientific agencies. How the funds are or are not spent and when they are spent needs to be enforced. The administration is playing games with our taxpayer dollars, when they should be going towards scientific innovation.
Max Kozlov@maxkozlov.bsky.social · 6mo agoCongress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇
We are excited to present this paper which has been the brain child of grad student Eric Malekos. He has taken all riboseq data and mass spec data available from immune cells and analyzed and categorized all potential sORFs. He performed 2 CRISPR screens in macrophages to identify functional sORFs.
bioRxivpreprint@biorxivpreprint.bsky.social · 7mo agoIntegrative multiomics analysis and CRISPR screening identify functional noncanonical translation loci in the mouse immune system. https://www.biorxiv.org/content/10.64898/2026.02.23.707583v1
New and competitive renewal awards. The number of awards is 569 compared with more than 2200 through the same date in earlier fiscal years. All ICs have now made awards except for NIAAA, NCCIH, NLM, FIC, and OD. NEI (Eye Institute) made its first award during the new period. 3/4
Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia | Science Immunology www.science.org/doi/10.1126/...
Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia
SFB colonization phenotypically alters alveolar macrophages, maintaining their antibacterial functions in inflamed interferon-rich lungs.
science.org
Today @nature.com, it's #AlphaGenome, to decipher and determine functionality of the regulatory (very challenging) variants in our genome. Another big step of AI for advancing life science nature.com/articles/s41...
How many STEM Ph.D.s were lost from the U.S. federal government last year? My colleagues @mghersher.bsky.social and @policyhound.bsky.social dug into a recent data release to find the answer. A @science.org exclusive. www.science.org/content/arti...
Nature Aging @nataging.nature.com turns 5 and asked ~50 researchers to reflect on the field. I am honored to contribute alongside colleagues whose work has shaped how I think about #aging science. Past, present and future perspectives on the science of aging www.nature.com/articles/s43...
Cost of being female lead/corresponding author in biomedical sciences: "[T]he median amount of time spent under review is 7.4%–14.6% longer for female-authored articles than for male-authored articles" even in disciplines where women well-represented. #AcademicSky journals.plos.org/plosbiology/...
Biomedical and life science articles by female researchers spend longer under review
Women are underrepresented in academia, especially in STEMM fields, at top institutions, and in senior positions. This study analyzes millions of biomedical and life science articles, revealing that f...
journals.plos.org
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
”never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession--and making it difficult for seasoned investigators to produce their best work”
Rescuing US biomedical research from its systemic flaws - PubMed
The long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession--and making it difficult for seasoned investigators to produ …
pubmed.ncbi.nlm.nih.gov