See also the great News&Views comment by Monica Gobran and @plenart.bsky.social - highlighting all three papers! link.springer.com/article/10.1...

Mitotic entry: Bora takes Polo to Aurora, and gives them a hug - The EMBO Journal

The EMBO Journal - Cell division involves the complete reorganization of the cellular architecture, requiring precise coordination of cellular processes in space and time, but how does this control...

link.springer.com

Additional complementary evidence by Arianna Esposito Verza, @andrea-musacchio.bsky.social et al link.springer.com/article/10.1... and by Anais Pillan, Lionel Pintard @ccdlab.bsky.social et al link.springer.com/article/10.1... in our sister journal @embojournal.org

Molecular requirements for PLK1 activation by T-loop phosphorylation - The EMBO Journal

Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...

link.springer.com

AlphaFold modeling & new assays for mitotic kinase activation in E. coli (#MITOKINAC) reveal molecular basis of specific Aurora A & PLK1 activation through Bora during mitotic entry Lionel Pintard @ccdlab.bsky.social et al #RefereedPreprint ℅ @reviewcommons.org link.springer.com/article/10.1...

Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry - The EMBO Journal

The evolutionarily conserved, intrinsically disordered protein Bora is critical for initiating the activation of mitotic kinases. Once phosphorylated at Ser112 by Cyclin A-Cdk1 kinase, phospho-Bora ac...

link.springer.com

AlphaFold protein interaction modeling tutorial and workshop thenode.biologists.com/https-www-yo...

AlphaFold protein interaction modeling tutorial and workshop - the Node

This video is the culmination of several years attempting to: (1) Figure out best practices for modeling protein-protein interactions; (2) Understand the This video is the culmination of several years...

thenode.biologists.com

Congrats, Ludivine, well done!

Institut Jacques Monod@ijmonod.bsky.social · 10mo ago

📣 Ludivine Roumbo, doctorante dans le laboratoire "Cycle cellulaire et développement" est lauréate du Prix Jeunes Talents France 2025 Fondation L'Oréal - UNESCO Pour les Femmes et la Science ! Plus d'informations 🔗 www.ijm.fr/prix-jeunes-... #FWIS2025 #ForWomenInScience #FemmesEnScience

#JobOffer 💼 Ingénieur d'études en analyse protéomique, H/F 📍 Plateforme ProtéoSeine 📅 1e septembre 2025 🔗 emploi.cnrs.fr/Offres/CDD/U... Candidatez avant le 12 mai 2025

✍️Our collaborative project with the @becklab.bsky.social (@mpibp.bsky.social) and the Kräusslich lab who applied innovative ultrastructural analyses to analyze nuclear pores in Nup133-/- embryonic stem cells and neural progenitors is now out @naturecomms.bsky.social! 🔗 www.nature.com/articles/s41...

Nuclear pores safeguard the integrity of the nuclear envelope - Nature Cell Biology

Taniguchi et al. structurally analyse nuclear pore complex architecture in situ during differentiation, which is associated with mechanical constraints on the nuclear envelope. They link nuclear pore ...

nature.com

✍️ The @pconduit.bsky.social Lab published a new article 📖 @currentbiology.bsky.social 📃 Asymmetric microtubule nucleation from Golgi stacks promotes opposite microtubule polarity in axons and dendrites 🔗 www.sciencedirect.com/science/arti...

Asymmetric microtubule nucleation from Golgi stacks promotes opposite microtubule polarity in axons and dendrites

The neuronal microtubule cytoskeleton is highly polarized, with most microtubules growing away from the soma in axons (plus-end-out), but many microtu…

sciencedirect.com

Greatwall kinase is key for mitotic entry in metazoans, so how can worms do without it? Pintard et al find sole canonical MAST kinase KIN-4 assumes its role in PP2A-B55 phosphatase inhibition and coordination of cell divisions and development in C. elegans www.embopress.org/doi/full/10....

We are delighted to share our latest study (www.embopress.org/doi/full/10....), where we identify and characterize a Greatwall-like pathway in C. elegans. Thanks to our sponsors @agencerecherche.bsky.social y.social, La Ligue Contre le Cancer, @ijmonod.bsky.social, @cnrsbiologie.bsky.social

The MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans | The EMBO Journal

imageimageGreatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single canonical MAST kinase family member KIN-4 is shown to fulfill thi...

embopress.org

✍️ The Léon Lab published a new article 📃 Direct observation of fluorescent proteins in gels: A rapid, cost-efficient, and quantitative alternative to immunoblotting 📖 Biology of the Cell 🔗 onlinelibrary.wiley.com/doi/10.1111/...

Direct observation of fluorescent proteins in gels: A rapid, cost‐efficient, and quantitative alternative to immunoblotting

This manuscript reports on the use of the endogenous fluorescence of green, orange, and red fluorescent proteins directly in gels after separation by SDS-PAGE. This protocol bypasses the need for mem....

onlinelibrary.wiley.com

#JobOffer 💼 Molecular biology and drosophila engineer (M/F) 📅 February, 17th 📍 Institut Jacques Monod / @pconduit.bsky.social's Lab Apply before February 6 ➡️ emploi.cnrs.fr/Offres/CDD/U... #Biology #Engineer

Our first paper on BlueSky!! Remarkable work published in @currentbiology.bsky.social from Jing Xie, Javad Najafi and others, on how cell shape affects mitotic spindle positioning forces in embryos, by impacting cytoplasm flows. @ijmonod.bsky.social www.sciencedirect.com/science/arti...

✍️ L'équipe Ladoux/Mege a publié un nouvel article dans @naturephysics.bsky.social 📃"Dynamic forces shape the survival fate of eliminated cells" 🔗https://www.nature.com/articles/s41567-024-02716-5 Article relayé dans @cnrsbiologie.bsky.social ➡️ www.insb.cnrs.fr/fr/cnrsinfo/...

Vie et mort des cellules épithéliales : le rôle clé des forces mécaniques

Les tissus épithéliaux, présents partout dans le corps humain, sont en interaction constante avec leur environnement.

insb.cnrs.fr

Benoit Ladoux@bladoux.bsky.social · 2y ago

Happy to share our new publication in @naturephysics.bsky.social on life and death of eliminated cells! Great collaboration between our CAM team and Doostmohammadi's. Special congrats @lakshmib02.bsky.social and Siavash Monfared! 🎉 www.nature.com/articles/s41...

La direction de l'Institut Jacques Monod ainsi ses équipes vous présentent leurs meilleurs vœux pour cette année 2025✨ The management of the Institut Jacques Monod and its teams wish you all the best for 2025✨

For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social Please RT !! research.pasteur.fr/fr/call/call...

Ana Almeida, Helder Rocha, Maximilian Raas, Geert Kops, Reto Gassmann, Helder Maiato @i3suporto.bsky.social, et al. dissect the relationship between kinetochore size & CENP-E dependence for chromosome alignment. journals.biologists.com/jcs/article/... journals.biologists.com/jcs/article/...