Cédric Maurange
@cedricmaurange.bsky.social
Group Leader at the Developmental Biology Institute of Marseille. Interested in stem cell trajectories during brain development and childhood cancers. https://www.ibdm.univ-amu.fr/team/neural-stem-cell-plasticity/
Exciting symposium on #CellPlasticity in Development and Diseases – Sept 21–22 | Paris Keynote speakers: — Sui Huang (Seattle) — Jessica Whited (Boston) Short talk slots available. Free to attend, registration mandatory. Abstract deadline: July 20th Registration: itbcrde.inserm.fr/index.php?pa...
I can’t agree more 👇🏻
Carlos Ribeiro@ribeirocarlitos.bsky.social · 5mo agoAmazing opportunity to hang out with the current and future leader who are shaping #Drosophila research in Europe. for me the @fly-jedi.bsky.social were one of the best things that happened in my early career. And this year the meeting is in a beautiful location in Portugal. Few spots left! Join!
Amazing opportunity to hang out with the current and future leader who are shaping #Drosophila research in Europe. for me the @fly-jedi.bsky.social were one of the best things that happened in my early career. And this year the meeting is in a beautiful location in Portugal. Few spots left! Join!
Junior European Drosophila Investigators@fly-jedi.bsky.social · 6mo agoCalling all #Drosophila #NewPI #researchers! A few spots remain for the upcoming JEDI Conference - and you won’t want to miss this! Every attendee gives a talk, making the exchange dynamic, personal, and highly interactive - all at a stunning venue that inspires collaboration and creativity.
Congratulations to these excellent CNRS PIs 🤩 for their promotion (pending a lot of bureaucracy🥲)! Full details in the link c3n-cn.fr/2025/12/12/c...
Congratulations to the brilliant scientists shortlisted for the auditions @cnrs.fr for cell bio dev bio and evo-devo #section24! Looking forward to hearing you in a few weeks. Many other amazing candidates were no less deserving and we hope to see them next year. sncs.fr/2025/12/11/c...
Concours CNRS 2026
Le SNCS-FSU s'engage à publier les classements d'admissibilité des concours chercheur-euses CNRS 2026.
sncs.fr
Tumours aren’t just a messy mix of cells—they’re highly organised and hierarchical societies! Just like in all societies, small chats between individuals can drive collective emergent behaviours - we reveal how these sustain tumour growth and cellular heterogeneity. 🧵👇
System-level regulation of hierarchical transitions in a tumour lineage
The fundamental principles defining how cell state transitions are regulated along a tumour lineage to determine its cellular composition remain unclear. Here, we investigate how such transitions are controlled in a reductionist hierarchical brain tumour model. Quantitative analysis of 3D transition maps revealed that the differentiation of cancer stem cells (CSCs) into transit amplifying progenitors (TAPs) depends on the identity of their immediate neighbours. This is embodied in a transition rule that quantitatively predicts the probability to differentiate as a function of the proportion of TAP neighbours. Integrated into 3D simulations of tumour growth, this rule spontaneously recapitulates spatial segregation of CSCs in clusters and their stable proportion. We further show in vivo that CSC clustering protects the CSC pool from depletion driven by TAPs. We identify an EGFR-mediated relay mechanism that propagates the CSC-to-TAP transition across CSC clusters. In CSCs, the LRIG1-like EGFR inhibitor Kekkon1 dampens this propagation, ensuring continuous replenishment of the CSC pool. Collectively, these findings show how local fate regulation drives emergent segregation which in turn constrains CSC differentiation dynamics. This provides a conceptual framework to understand and exploit the tumour’s intrinsic differentiation potential by manipulating the determinants of its system-level features. ### Competing Interest Statement The authors have declared no competing interest. Turing Centre for Living Systems (CENTURI) La Ligue Contre le Cancer, https://ror.org/00rkrv905, Equipe Labellisée LIGUE 2025 Fondation pour la Recherche Médicale, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Agence Nationale de la Recherche under the France 2030 program, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Centre South-ROCK, INCa-Cancer_18695
biorxiv.org
Tumours aren’t just a messy mix of cells—they’re highly organised and hierarchical societies! Just like in all societies, small chats between individuals can drive collective emergent behaviours - we reveal how these sustain tumour growth and cellular heterogeneity. 🧵👇
System-level regulation of hierarchical transitions in a tumour lineage
The fundamental principles defining how cell state transitions are regulated along a tumour lineage to determine its cellular composition remain unclear. Here, we investigate how such transitions are controlled in a reductionist hierarchical brain tumour model. Quantitative analysis of 3D transition maps revealed that the differentiation of cancer stem cells (CSCs) into transit amplifying progenitors (TAPs) depends on the identity of their immediate neighbours. This is embodied in a transition rule that quantitatively predicts the probability to differentiate as a function of the proportion of TAP neighbours. Integrated into 3D simulations of tumour growth, this rule spontaneously recapitulates spatial segregation of CSCs in clusters and their stable proportion. We further show in vivo that CSC clustering protects the CSC pool from depletion driven by TAPs. We identify an EGFR-mediated relay mechanism that propagates the CSC-to-TAP transition across CSC clusters. In CSCs, the LRIG1-like EGFR inhibitor Kekkon1 dampens this propagation, ensuring continuous replenishment of the CSC pool. Collectively, these findings show how local fate regulation drives emergent segregation which in turn constrains CSC differentiation dynamics. This provides a conceptual framework to understand and exploit the tumour’s intrinsic differentiation potential by manipulating the determinants of its system-level features. ### Competing Interest Statement The authors have declared no competing interest. Turing Centre for Living Systems (CENTURI) La Ligue Contre le Cancer, https://ror.org/00rkrv905, Equipe Labellisée LIGUE 2025 Fondation pour la Recherche Médicale, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Agence Nationale de la Recherche under the France 2030 program, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Centre South-ROCK, INCa-Cancer_18695
biorxiv.org
Super happy to share the exciting work of Emma Legait, showing how neighbourhood composition determines cancer stem cell fate in hierarchical tumours. A great and long-standing collaboration with @cedricmaurange.bsky.social www.biorxiv.org/content/10.6...
Il n'est plus tenable que notre gouvernement et, par là même, les médias qui relaient ses communications (ainsi que les verbatims de toutes les personnalités politiques), s'expriment via un outil de propagande fasciste étranger ! À vos signatures 👇 petitions.assemblee-nationale.fr/initiatives/...
Cesser d'utiliser X (anciennement Twitter) pour les communications officielles du gouvernement - Cesser d'utiliser X (anciennement Twitter) pour les communications officielles du gouvernement - Platef...
Cessez d'utiliser cette plateforme comme l'un des principaux porte-parole des communications officielles en France. Il existe des alternatives bien mieux modérées et régulées, et il est même possible ...
petitions.assemblee-nationale.fr
💥🥚 ANR-funded Assistant Engineer position open in our “Control & Dynamics of the Ovarian Cycle” group at IBDM Marseille 🇫🇷 Work on mouse lines + lab logistics + follicle culture/imaging 🔬 🗓️ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U... Please share widely — especially with colleagues in France!
Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics
Biophysics of organoids
In this review, Weichselberger, Moore et al. discuss how physics-based approaches illuminate organoid development and homeostasis by integrating mechanical, chemical, and informational processes. They...
dlvr.it
First-ever atlas of brain development shows how stem cells turn into neurons There are 6 excellent human brain development papers in Nature - www.nature.com/articles/d41... Check them out!
🚨🚨🚨 The SFBD board needs to be renewed with 5 members We wish to strengthen our board with young scientists To apply: send a brief text introducing your research interests and motivations to sfbd@sfbd.fr by December 4th Elections will be held online from December 10th to 17th Please share the info
🚨 Exciting conference for stem cell aficionados! ‘Frontiers in Stem Cell Innovation’ will bring together experts in stem cell biology from academia & industry to discuss key developments as well as challenges in regenerative medicine and disease modelling. fisci2026.eventbrite.co.uk Please repost 🙏
Frontiers in Stem Cell Innovation 2026
Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery
fisci2026.eventbrite.co.uk
Paul Nurse describing the main job of a PI (From ‘The Thinking Game’, 2024)
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/3X5lbUg
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
Nature - In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
go.nature.com
Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 11mo agoHierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1
Starting Monday!!! If you are in Paris, feel free to drop in for this exceptional course!
Bardin Lab@bardinlab.bsky.social · last yr.Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included. training.institut-curie.org/courses/deve...
Self-organizing principles driving hierarchical transitions and cell heterogeneity in colorectal tumors. Very interesting work!
Carlos Pérez-González@cperez-gonzalez.bsky.social · 11mo ago1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social : "Self-organization of tumor heterogeneity and plasticity" biorxiv.org/content/10.1... Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated? A thread👇
Excited to share our new #biorxivpreprint: “Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1... We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
🎂 Mon blog (Neuro)biologie et société (neurobiologieetsociete.org) associé au @cafe-sciences.org a 10 ans en ce mois d'octobre 2025 ! neurobiologieetsociete.org Les 5 billets les plus populaires au cours de ces 10 ans 👇 : #CultureScientifique #vulgarisationscientifique
(Neuro)biologie et société
Voir l’article pour en savoir plus.
neurobiologieetsociete.org
Reprigramming of neural crest cells to mesodermal fates drives Ewing sarcoma…. Very nice study using zebra fish! www.cell.com/cell-reports...
Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm
Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence for a neural crest origin of the disease. These findings offer new insight into how a single oncogenic fusion can hij...
cell.com
Il n’est pas acceptable qu’un pays développé comme la France ignore l’ensemble des causes d’une incidence singulière du cancer. www.lemonde.fr/idees/articl...
Cancer : la France doit savoir pourquoi elle est surexposée
ÉDITORIAL. L’étude du « Lancet », qui a placé la France en tête des pays les plus touchés, doit servir de signal d’alarme. Qu’un pays développé ignore l’ensemble des causes d’une incidence singulière ...
lemonde.fr
Developmental Biology lost a giant yesterday 😔 May his legacy thrive and keep inspiring current and future generations of scientists www.gurdon.cam.ac.uk/nobel-laurea...
Nobel Laureate Professor Sir John Gurdon Dies Aged 92 – Gurdon Institute
gurdon.cam.ac.uk
Abstract deadline (Dec 15th) approaching for the 2026 Neurogenesis meeting in Ascona. The last one was outstanding, so we’re all really looking forward to this second edition. Reassuringly in this day and age it’s held on the “Mount of Truth”.
Denis Jabaudon@djabaudon.bsky.social · 12mo agoInterested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT neuro-unige.ch/news/csf-mee...
Great clip. About PhDs here on H1B’s that “create entire industries.”
Raider@iwillnotbesilenced.bsky.social · 12mo agoMichio Kaku on H1B being the secret weapon of the US.
🧠 You are in Marseille on September 29th and interested in neurodevelopmental questions, don't forget to register to our symposium "Linking neural development, human disease and evolution". To register: evento.renater.fr/survey/mini-... @neuromarseille.bsky.social @ibdm.bsky.social
Répondre au sondage - Mini-symposium "Linking neural development, human disease and evolution" - Evento
evento.renater.fr
Baptiste Libé-Philippot@blibep.bsky.social · last yr.🧠 I am happy to organise on September 29th 2025, with @sophiechauvet.bsky.social, a Symposium "Linking neural development, human disease and evolution" in the Hexagone, Luminy, Marseille. More detailed for the schedule and registration below!
