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Advances in Pancreatic Neuroendocrine Tumor (PNET) Treatments

Dr. Diane Reidy-Lagunes outlines the current state of treatments for pancreatic neuroendocrine tumors (PNETs).

bit.ly

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches

Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast (apCAF) populations across multiple cancer types. Mesothelial-related apCAFs locate near cancer cells while fibrocyte-...

cell.com

Identification, functional insights and therapeutic targeting of EMT tumour states

Nature Reviews Cancer, Published online: 25 September 2025; doi:10.1038/s41568-025-00873-0In this Review, Dong and Blanpain outline our current understanding of the epithelial-to-mesenchymal transition in cancer, which we now know is not a simple binary switch but the existence of a series of different tumour states. The authors also discuss the implications of this knowledge for pharmacologically targeting epithelial-to-mesenchymal transition to overcome therapy resistance.

nature.com

Aix-Marseille University hiring Ingénieur Pédagogique développement d’une formation en e-learning in Marseille, Provence-Alpes-Côte d'Azur, France | LinkedIn

Posted 8:38:34 AM. Nous cherchons un·e Ingénieur·e pédagogique (F/H) en CDD de 12 mois pour développer une formation…See this and similar jobs on LinkedIn.

linkedin.com

Unraveling the glyco-immunity nexus in pancreatic cancer - Molecular Cancer

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease, and standard of care therapies have failed to yield significant clinical benefit, with invasive surgery being the only curat...

molecular-cancer.biomedcentral.com

Is your AI benchmark lying to you?

Artificial intelligence models are too often assessed against flawed goals — a stumbling block for progress.

go.nature.com

EBV induces CNS homing of B cells attracting inflammatory T cells - Nature

Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

nature.com

Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

Overcoming resistance to KRAS∗-targeted therapy remains a major challenge. Theardy et al. demonstrate that YAP1 drives the recovery of surface SDC1 upon KRAS∗ inhibition by downregulating ARF6 GAPs, thereby activating RTKs and macropinocytosis to promote resistance. Targeting the YAP1-SDC1 axis represents a promising strategy to combat resistance in KRAS∗-driven cancers.

dlvr.it

High levels of circular DNA made as immune cells develop increases the risk of leukaemia relapse

DNA segments that are naturally excised during immune-cell development can replicate, drive damage at various genomic sites and lead to cancer recurrence.

go.nature.com

Stressomic: A wearable microfluidic biosensor for dynamic profiling of multiple stress hormones in sweat

A wearable sensor enables dynamic and noninvasive monitoring of multiple stress hormones to personalize stress management.

science.org

What You Need To Know About Screening for Pancreatic Cancer | PancChat Podcast with Alisyn Camerota | Episode 4

Who should be screened for pancreatic cancer, and when should it start? In this episode of PancChat, host Alisyn Camerota speaks with leading experts Dr. Michael Goggins (Johns Hopkins) and Dr. Anirban Maitra (MD Anderson / NYU Langone) about identifying higher-risk individuals and creating...

f.mtr.cool

Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI

Nature Reviews Gastroenterology & Hepatology, Published online: 31 July 2025; doi:10.1038/s41575-025-01100-9Artificial intelligence (AI) is a powerful tool that could be applied to microbiome research. This Perspective discusses best practices and current limitations with the application of AI in microbiome data research, giving insights into future use and practical advice and recommendations on its use.

nature.com

Portail Emploi CNRS - Offre d'emploi - Postdoctoral researcher in human neurobiology (M/F)

emploi.cnrs.fr

Precisely defining disease variant effects in CRISPR-edited single cells - Nature

A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants on cell state and function.

go.nature.com

Association between ultra-processed food consumption and lung cancer risk: a population-based cohort study

Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent. Research question Are UPF associated with an increased risk of lung cance...

thorax.bmj.com

Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer

Chen et al. integrate sc/snRNA-seq with spatial transcriptomics to characterize cellular composition, lineage dynamics, and spatial architecture in PDAC tissues with varying neural invasion status, un...

cell.com

JCI - What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment

jci.org

Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation

Inhibition of a distinct macrophage subcluster is expected to hinder recurrence of pancreatic cancer after IRE ablation.

science.org

Stanford cancer scientists awarded funding for cancer AI

A team of Stanford cancer scientists has been awarded to develop AI models that integrate different data types and identify biomarkers to predict whether a patient will respond to a specific cancer…

med.stanford.edu

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets

Knol et al. report a large pan-cancer proteome landscape based on high-throughput, single-shot mass spectrometry across 22 cancer types including both liquid (n = 4) and solid cancers (n = 18), revealing co-expression-based phenotypes and immune phenotypes and defining top 25 ranked proteins as potential biomarkers and drug targets for each cancer type as well as a multi-cancer classifier.

dlvr.it