Why do COX-inhibitors like aspirin and celecoxib help prevent and treat colorectal cancer (CRC)? Our new preprint suggests part of the answer is that they work as ‘anti-plasticity’ drugs. (1/7) www.biorxiv.org/content/10.6...
Chris Tape
@christophertape.bsky.social
Group Leader, UCL Cancer Institute. Studying how different cell-types collaborate to drive cancer | http://tape-lab.com
We are recruiting! We are searching for an exceptional postdoctoral fellow to lead the single-cell phenoscaping efforts of the REWIRE-CAN Cancer Grand Challenge @cancergrand.bsky.social For more information and to apply please visit: www.ucl.ac.uk/work-at-ucl/...
Congratulations to Prof Bart Vanhaesebroeck, Prof @christophertape.bsky.social & Team REWIRE-CAN on securing $25m in @cancergrand.bsky.social funding to take on the challenge of rewiring cancer cells. #CancerGrandChallenges @uclmedsci.bsky.social www.ucl.ac.uk/news/2026/ma...
UCL-led international research team wins $25m Cancer Grand Challenges funding
Team REWIRE-CAN, led by Professor Bart Vanhaesebroeck of the UCL Cancer Institute, will receive up to $25m over approximately five years to take on the rewiring cancer cells challenge.
ucl.ac.uk
In early-2025 I was reeling from a ‘scored fundable’ grant application that was not funded. I really believed in this grant and knew the ideas were good but the review panel just weren’t into the project and there nothing more I could do. That’s science, but it hurts. (1/8)
Annual lab curry ‘n’ karting. Incredibly privileged to work alongside these wonderful people
It's been a HUGE privilege to interview for @cancergrand.bsky.social with the incredible REWIRE-CAN team
(1/N) Thrilled to share that our paper HiPoNet (High dimensional Point cloud Network) to be presented at NeurIPS 2025! HiPoNet treats an entire high-dimensional point cloud as a datapoint! It captures multi-scale geometry and topology of the cloud perform classification and regression tasks.
Paul Nurse describing the main job of a PI (From ‘The Thinking Game’, 2024)
Important new paper from @batllelab.bsky.social showing how the KRAS-G12D inhibitor (RMC-9945) triggers rapid stem cell switching in CRC. This switch happens in just a few hours — similar to what we see with tumour cell responses to CAFs. aacrjournals.org/cancerdiscov...
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13) aacrjournals.org/cancerres/ar...
Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme. If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch! www.colcc.ac.uk/2026-blic-ph...
A warm welcome to the newest member of the team: Lab-bubu
We are recruiting! Our lab is looking for a new mass cytometry technician to help study colorectal cancer organoid perturbation experiments at scale. Please feel free to contact me with any questions! Full job description and application details here: www.ucl.ac.uk/work-at-ucl/...
🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals. ✅ Wet & dry lab ✅ September 2025 enrolment ✅ UK tuition fees only www.ucl.ac.uk/medical-scie...
Pre-Cancer Immunology
The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.
ucl.ac.uk
Incredibly impressed by the student/postdoc run @bacell3d.bsky.social conference. Great talks, a vibrant community, and so well organised 👏
Very excited to have Prof. Chris Tape (University College London, UK) “Single-cell Phenoscaping of Tumour Microenvironment Organoids @christophertape.bsky.social What makes the phenotype of a cell?
Congrats to Rhianna O’Sullivan for winning a poster prize at the UCL Cancer Institute conference! 👏
🏆 UCL is ranked 9th globally in the 2026 QS World University Rankings for the third year in a row. This marks our 14th year in the global top 10, reflecting the strength of our academic and employer reputation. 🔗 Learn more: www.ucl.ac.uk/news/2025/ju... #QSWUR
🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR
2nd European Cancer Dependency Map Symposium - Human Technopole
The 2nd European Cancer Dependency Map Symposium is a scientific event open to the national and international scientific community working in computational genomics, pharmacogenomics, and therapeutic ...
humantechnopole.it
Human Technopole@humantechnopole.bsky.social · last yr.🔬 Join us in Milan for the 2nd European Cancer Dependency Map Symposium #ECDM25! A key event for scientists in functional genomics & target discovery. Talks, panels, AI & poster sessions await. Register now 👉 humantechnopole.it/en/trainings...
2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!
Chris Tape@christophertape.bsky.social · last yr.We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...
Happy to share details of this meeting and the exciting line-up of speakers. Hope to see you there. Please re-post www.crick.ac.uk/whats-on/5th...
We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...
Excited to arrive in Whistler for the @keystonesymposia.bsky.social on Organoids and Single Cells 🇨🇦 🐻
"We’re going to find a way to kill these cells,” says @christophertape.bsky.social “We won’t stop until we do.” Loved working on this piece with Chris & his team - and with Sharon, who donated her bowel tumour to Chris's @cancerresearchuk.org -funded lab. news.cancerresearchuk.org/2025/05/09/s...
The mysterious stem cells that could hold the key to beating bowel cancer - Cancer Research UK - Cancer News
Using organoids, researchers have found that 'revival' stem cells could hold the key to why people's cancers respond differently to treatment
news.cancerresearchuk.org
Thanks to @cancerresearchuk.org for featuring our work on stem cell plasticity in CRC: news.cancerresearchuk.org/2025/05/09/s...
The mysterious stem cells that could hold the key to beating bowel cancer - Cancer Research UK - Cancer News
Using organoids, researchers have found that 'revival' stem cells could hold the key to why people's cancers respond differently to treatment
news.cancerresearchuk.org
Congrats to Corinne Molyneux for winning a poster prize at the UCL Cancer Domain Symposium! 👏
If you’re interested in GI organoids please join us for the first LION meeting at The Crick 09/06! 🦁
Joana F Neves@nevesjf.bsky.social · last yr.Inaugural LION (London gastroIntestinal Organoid Network) symposium @crick.ac.uk June 9th. Registration and details at www.eventbrite.co.uk/e/london-gas.... #Organoids #intestine #IBD #CRC @christophertape.bsky.social @vivianlilab.bsky.social @graycamplab.bsky.social @paolodecoppi.bsky.social