Binders for all!

AI x Bio Discovery@aixbiobot.bsky.social · 6d ago

The Human Bindome: A Proteome-scale Atlas of Designed Binder Candidates [new] ...provides genetically encodable perturbagens with defined sequences for modular, site-specific protein function control, openly available.

Amazing, well done Bronte!

Bronte Johnstone@bjohnstone.bsky.social · 3d ago

I am delighted and incredibly grateful to share that I have been awarded a NHMRC Emerging Leadership (EL1) Investigator Grant!

Take a look at our new paper on the structure of the EHD2 that, upon oligomerization, forms rings that remodel the plasma membrane and form caveolae. Beautiful work by Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff & Oliver Dumke's team; take a look: www.nature.com/articles/s41...

Sometimes I really miss the old Science Twitter that fizzled out around 2023. 🥺

My 4yo came home from his first day at STEM summer camp and said, “There are a lot more boys than girls there. I think science is for everyone.” 🥺 🧪

Very excited to see this work, on our insecticidal pore forming protein come out. This was an enormous amount of work and outstanding collaboration between Monash and Cardiff Uni. first put together by Prof Colin Berry. www.nature.com/articles/s41...

#DiscoveryProjects #DP27 Detailed assessor reports should be released in ARC's RMS tomorrow (23 Jun). Normally about 11am, Canberra time (but it varies). Remember the #ARC3DayRule: Think an assessment is "inappropriate"? You've only got 3 days to lodge a "request for review" 👇

Oooooh I'm feeling inspired

Niki Hubbard, PhD 🐙🦀@nikihubbard.bsky.social · 4mo ago

Always a rare treat when I am lucky enough to spot a tiny clown doris! One of my missions is still to get a better photo of one too 😅 🤡 The R package has been uploaded to CRAN for review! #nudibranch #rstats #dataviz 🦑🐙🧪 #marinelife #invertebrates

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Well done! Congratulation Jordan! 🍾🎉

Gökhan Tolun@gokhan-tolun.bsky.social · 3mo ago

We academics live for days like these! Yesterday was the graduation of my PhD student Jordan Nicholls. A truly proud moment for me as his primary supervisor. I wish him the best in his future career. Others in the picture are to follow, some of them quite soon (already writing their theses!).

1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).

Sad news coming from our colleagues in the US. A friendly reminder to those who have missed out that we have grad school positions available and we value you! Maybe this is an opportunity to make Melbourne, Australia your new home. Please boost.

Jay Van Bavel, PhD@jayvanbavel.bsky.social · 5mo ago

I've seen a lot of demoralized posts (and emails) from people who didn't get into grad school this cycle. This was one of the worst cycles I've ever seen due to massive cuts to research funding, financial difficulties at universities, and technological disruptions.

FlashPPI is our new proteome-wide protein-protein interaction prediction model. If you haven't had a chance to try FlashPPI yet, here's what the end-to-end flow looks like in SeqHub:

🌀 We solved the structure for T. denticola periplasmic flagella! I'm very happy to finally showcase this work. A huge collaborative effort between myself, @bindusmitapaul.bsky.social, @debnathghosal.bsky.social, Jack Kim, @banfieldlab.bsky.social, Eric Reynolds and the Chris Fenno lab. 🦠 Enjoy!

bioRxivpreprint@biorxivpreprint.bsky.social · 6mo ago

Structural basis for curvature generation and functional specialization in spirochete flagella https://www.biorxiv.org/content/10.64898/2026.02.04.703737v1

To learn more, you can find our new preprint here! 13/13 www.biorxiv.org/content/10.6...

We developed a single-molecule, multiplexed, microfluidic force spectroscopy (SM3FS) assay that arrays many flow chambers in one FOV. Additional multiplexing enabled library-scale experiments. 4/13

At #BPS2026? 🧬 Come talk structural biology & mTORC1 signaling! I'll be at Poster B220 this Tuesday, 2:45–3:45 PM. I’m also building the Cui Lab at CU Anschutz and looking for postdocs/students interested in Cryo-EM and ML. Let's chat! 🧪🏔️ #Biophysics #CryoEM #StructuralBiology

www.nature.com/articles/s41...

Laser writing in glass for dense, fast and efficient archival data storage - Nature

An optical archival storage technology based on femtosecond laser direct writing in glass addresses the practical demands of archival storage.

nature.com

Introducing AlphaFast 🚀. AF3 is transformative but too slow for large-scale protein design. My students Ben and Jeonghyeon made it 10-100x faster using GPU-accelerated sequence search. Preprint: www.biorxiv.org/content/10.6...  Code: github.com/RomeroLab/al...

New issue alert 👉 www.cell.com/cell/current On the cover, McCallum et al. depict a fluorescent micrograph showing a engineered biosensor strain in the mouse colon, illustrating how commensal bacteria can serve as in situ reporters of dynamic gut physiology.

I’ve officially started my lab at Monash University! 🎉 We’re diving into #cellgrowth and #lysosome biology, through the lens of molecular #structure and mechanism. I’m thrilled to say that PhD student scholarships are available—so please share widely and get in touch if you’re interested. 🤩

Tried it. Its awesome. Shame the code isn't available. Webserver only, how long will it last??

cryoEM papers@cryoempapers.bsky.social · 6mo ago

Accurate Macromolecular Complex Modeling for Cryo-EM with CryoZeta www.biorxiv.org/content/10.64898/2026.02.13.705846v1 #cryoEM

I've heard this position articulated by a lot of people, but I think this is hard to make precise. Much of this tracks a problem we already know in science: standards of authorship are not stable and there are many difficult edge cases. Consider these cases...

Iris van Rooij 💭@irisvanrooij.bsky.social · 6mo ago

Seeing ppl debate how to deal with paper submissions that are partly written by “AI”. Why are we having that conversation? I would refuse to review or edit any paper that was not 100% written by its authors (i.e., the people who have authorial responsibility for the creation of a papers content).

Physically Grounded Generative Modeling of All-Atom Biomolecular Dynamics www.biorxiv.org/content/10.64898/2026.02.15.705956v1 #cryoEM

Metadynamics meets diffusion-based structure prediction: the same trick that drives enhance sampling of MD trajectories can be adapted and applied as steering terms during generation to sample diverse conformations. Seems obvious in hindsight!

AI x Bio Discovery@aixbiobot.bsky.social · 6mo ago

Metadiffusion: inference-time meta-energy biasing of biomolecular diffusion models [new] Steers PT diffusion models via grad-guided denoising to generate diverse biomol. conformations beyond compact DB biases, without retraining.

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

A small polymerase ribozyme that can synthesize itself and its complementary strand

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

science.org

New online: Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex

Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex

Nature Structural & Molecular Biology, Published online: 12 February 2026; doi:10.1038/s41594-026-01746-2Tafur et al. determined the cryo-electron microscopy structure of the SEA complex (GATOR) bound to its substrate, the EGO complex (Ragulator–Rag), and showed that its GAP activity is essential for both rapid inactivation and reactivation of TORC1.

dlvr.it

New preprint from the Robertson Lab! We used AF ensemble generation for rigidity filtering with generative design to make cryoEM fiducials, enabling rapid inactive states of four drug targets and a beta2 extracellular fiducial to study GPCR activation! www.biorxiv.org/content/10.6...

Nature research paper: Construction of complex and diverse DNA sequences using DNA three-way junctions go.nature.com/4qu2ExZ

Construction of complex and diverse DNA sequences using DNA three-way junctions - Nature

Sidewinder enables high-fidelity DNA assembly by separating the information that guides assembly from the final assembled sequence.

go.nature.com

Not just biomedicine! Chemistry, physics, computer science, climate? Both ARC and NHMRC massively under funded. Success rates abysmal. Skeptical of claim re budget increase by 250%? Aus R&D expenditure (%GDP) is stagnant, significantly below OECD average. Inflation. Rising costs. USA exit. ?!?

Dr Monique Ryan@mon4kooyong.bsky.social · 7mo ago

In the words of a world-renowned cardiologist, Australia’s young medical researchers are “left to flounder with total job insecurity and family pressures. It’s the best recipe we have for raiding our future, in terms of a medical research workforce and the benefits of medical research”