Okazaki fragments–how Tsuneko & Reiki Okazaki found the solution to the "lagging strand" problem

YouTube video by the bumbling biochemist

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Engineering the paclitaxel biosynthetic pathway in Physcomitrium patens for de novo and stable biosynthesis - Nature Communications

Paclitaxel is a highly valuable diterpenoid anticancer drug originally extracted from the yew tree. Here the authors genetically engineer the moss, Physcomitrium patens, for de novo paclitaxel biosynt...

nature.com

A deep learning model captures position-specific effects of plant regulatory sequences and suggests genes under complex regulation

Abstract. Deep neural networks can be trained to predict gene expression directly from genomic sequence, thereby implicitly learning regulatory sequence pa

doi.org

A simple and reliable method for determining kanamycin sensitivity in Brassica napus

Dear Editor,

doi.org

Death and chemotaxis: Bacterial chemotaxis enables collective escape from phage predation

Bacteriophages (“phage”) are viruses that prey on bacteria in diverse environments, from biological tissues to soils. In many of these environments, bacterial hosts are constantly migrating, yet how b...

science.org

Arabidopsis thaliana triggers Phelipanche ramosa germination via isothiocyanates under negative strigolactone regulation

Abstract. Parasitic weeds are major agricultural threats through fine-tuned chemical interactions with their hosts. We investigated the germination-stimula

academic.oup.com

Upregulated jasmonate signaling shifts Arabidopsis microbiota interactions and stress adaptations through a positive feedback loop

Abstract. The model plant Arabidopsis thaliana hosts diverse microbial communities collectively known as the microbiota. The plant microbiota is generally

academic.oup.com

A simple seed-piercing transformation protocol for pearl millet and finger millet

Pearl millet and finger millet are important food crops but are notoriously recalcitrant to genetic transformation and gene editing, limiting their improve

doi.org

Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome - Nature Biotechnology

Optimized long-read sequencing constructs megabase-scale genome assemblies from complex soil samples.

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Genetic and epigenetic divergence among Arabidopsis thaliana Col-0 laboratory lineages since the 1950s

The model plant Arabidopsis thaliana has been a workhorse of plant biology since the 1950s, when the Columbia-0 (Col-0) accession was widely adopted by the research community as a reference genotype. ...

biorxiv.org

Characterisation of gene expression markers and glucosinolates during discrete infection stages of Pyrenopeziza brassicae in Brassica napus

Light leaf spot (LLS), caused by subcuticular hemibiotrophic ascomycete fungus Pyrenopeziza brassicae , is a major constraint on oilseed rape ( Brassica napus ) production, yet the genetic and biochem...

biorxiv.org

Asst Professor - Plant or Fungal Genomics - Wyoming, United States job with University of Wyoming | 37970472

Asst Professor - Plant or Fungal Genomics Join Our Campus Community! Thank you for your interest in joining the University of Wyoming. Our...

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BisCEET: A Visual Browser for Biosynthetic Gene Clusters Aiding in the Identification of Natural Product Variants and Distinct Tailoring Enzymes

Genes involved in the biosynthesis of microbial natural products (NPs) are typically arranged in biosynthetic gene clusters (BGCs). Different congeners of an NP family typically possess distinct chemical features introduced by additional tailoring enzymes encoded in the corresponding BGC variants. However, tools to rapidly visualize the core gene set and distinguish it from variant-specific tailoring genes (VSTGs) in these BGCs are lacking. Here, the software tool BisCEET (Biosynthetic Cluster Environment Examination Tool) was developed, allowing comparison and visualization of the gene composition of related BGCs, thereby streamlining the identification of VSTGs in uncharacterized BGC variants and strains likely to produce novel NP congeners. The use of BisCEET is exemplified by analyzing bacterial BGCs of staurosporine-like indolocarbazoles and xantholipin-like polyketides, which enabled the identification of numerous apparent BGC variants. We anticipate that BisCEET will become a valuable bioinformatic asset, streamlining the prioritization of BGCs and the cultivation of microbial strains for the discovery of distinct NP variants and novel tailoring enzymes.

pubs.acs.org

Zintellect - U.S. Department of Agriculture (USDA) - USDA-ARS Postdoctoral Fellowship: Automated Field Phenotyping for Crop Stress Detection - USDA-ARS-NEA-2026-0158

*Applications are reviewed on a rolling-basis. ARS Office/Lab and Location: A research opportunity is currently available with the U.S. Department of Agric

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Plant microbiota feedbacks through dose-responsive expression of general non-self response genes

Nature Plants - The plant general non-self response system is triggered by leaf microbiota members and, in turn, impacts their colonization.

nature.com

Functional insights into dispensable genes using genome-wide loss-of-function burden tests in Arabidopsis

Genome-wide loss-of-function burden tests in Arabidopsis reveal functional insights into dispensable genes and demonstrate how collapsing variants by funct

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