My son's favorite thing to do in Amsterdam is to visit the Huttendorp in the Jeugtland playground. He shows up, they give you a hammer, nails and a saw and off he goes to play around with wood and build something.

Join us in Budapest in October! There is still time to register with an abstract. Talk and flash talk slots, a great speaker line up at an informal meeting on epigenetics, gene and genome regulation etc. in a beautiful city. shorturl.at/fOuCZ. For that to do list before the holidays!

Really proud PI here. Felix is fantastic and it is so much fun to work with him on his project. Congratulations on this achievement!

Max Perutz Labs Vienna@maxperutzlabs.ac.at · 4w ago

👏 Congrats to Felix Haslhofer (Bücker lab), this year’s Max Perutz PhD Fellow! 💡 His project combines synthetic genomics, high-throughput screening, and deep learning to uncover how enhancers communicate with genes across large genomic distances ➡️ tinyurl.com/mvtf637y

Here is a big thank you to the student who wrote in the exam that the DNA is packaged tightly into heterochromatin or loosely into homochromatin. You made my day brighter and full of laughter.

Alois is one of the most dedicated and awesome teachers we have at the Perutz and @univie.ac.at. Every time he teaches his practical course, the students hang on his lips and learn so much. He is a treasure, and I am glad that we could show him some of that appreciation with this award.

Max Perutz Labs Vienna@maxperutzlabs.ac.at · last mo.

🎉 Congratulations to Alois Schweighofer on receiving the @univie.ac.at Teaching Award for the Max Perutz Labs! Recognized for his outstanding commitment to teaching and student engagement, Alois creates a learning environment where students are encouraged to try out their ideas 🙌

We've got a stellar lineup for the last Fragile Nucleosome Seminar before our summer break!

FragileNucleosome@fnucleosome.bsky.social · 2mo ago

🧬This Wednesday will be the final seminar of the Spring 2026 #FNucleosome schedule, and we've got a great one lined up! Join us to hear about the outstanding research of @annanordin.bsky.social, @valentinabaderna.bsky.social, and @kezlane.bsky.social! register here: us06web.zoom.us/webinar/regi...

Congratulations, Yinan!

Yinan Wan@yinanwan.bsky.social · 2mo ago

Excited to share that I will start my lab at the Center for Integrative Genomics in Lausanne @unil.bsky.social in Jan 2027! I’m looking for PhD students fascinated by how cells build tissues and excited about developing new technologies to study development across scales. www.wanlab.bio/pages/9397

Join is in Budapest in October! For the 6th time, all things epigenetics, gene and genome regulation and more. A fantastic opportunity to present, to talk to speakers and colleagues in a friendly, informal setting at a great location. Please note, travel grant deadline will expire soon.

Congratulations, Victoria and the whole Pauli team!

Victoria Deneke@vdeneke.bsky.social · 3mo ago

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇

I have a love/hate relationship with traveling for work. It is exhausting and takes you away too much from family. But then you have some of these trips that invigorate you and make you realize why you love your job. The conversations with like-minded people, making new friends and getting inspired.

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

really cool! congratulations and some food for thought!

Elias Friman@eliasfriman.bsky.social · 3mo ago

Is distal gene activation by enhancers inherently different from promoter-proximal activation? We propose not. But both cohesin and cooperativity are important aspects of how transcription is affected. Happy to share our recent preprint (thread below) 1/ www.biorxiv.org/content/10.6...

I would go for it, if I would be young! Cool question and great supervisor!

MC Gambetta@mcgambetta.bsky.social · 3mo ago

Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity

Love that mural. and the rest of the @maxperutzlabs.ac.at

Thiago Carvalho@cyrilpedia.bsky.social · 3mo ago

Hello Vienna

New paper out in @cp-cellstemcell.bsky.social. We uncover unexpected complexity in how metabolism changes when the embryo implants or when stem cells exit naive pluripotency, revealing a central role for dynamic TCA cycle rewiring in cell fate decisions. www.cell.com/cell-stem-ce...

TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency

Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al. show that TCA cycle rewiring underlies mouse embryo implantation and the exit from naive pluripotency. In this context...

cell.com

When do lineage biases first emerge in the epiblast? They are detectable before gastrulation, but how this early asymmetry is established has remained unclear. A CRISPRa screen identifies WT1 as an unexpectedly early regulator of formative pluripotency. (1/4)

I really appreciate this discussion! Teaching at all levels needs this discussion right now.

Arjun Krishnan@compbiologist.bsky.social · 4mo ago

What is the PhD actually for, especially now that AI can do increasingly more of what we train scientists to do? compbiologist.substack.com/p/what-is-th... A response to @pracheeac.bsky.social's thought-provoking essay "Free the PhD".

Exciting job offer: PhD Program Manager. Lead recruitment, support PhD candidates, and shape doctoral training at a top international life sciences campus. https://ow.ly/3YkN50YAuGM Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology

Our work on the role of Ufmylation on ribosome quality control on the ER is out! Great work of two terrific first authors Milica and @alessandrick.bsky.social together with our wonderful collaborators, the one and only Dagdas lab @plantophagy.bsky.social!

Max Perutz Labs Vienna@maxperutzlabs.ac.at · 4mo ago

🆕 publication! The @gekaragoz.bsky.social lab shows how cells clear stalled ribosomes at the ER, preventing harmful 'traffic jams' during protein synthesis🚦Their new @embojournal.org study reveals how quality control and UFMylation team up to keep translation moving ➡️ tinyurl.com/2czj8fvp

The BioOptics facility will expand their team with a Junior Imaging Scientist with a background in Biological Sciences, who is enthusiastic about applying cutting-edge light microscopy for imaging-based research 🔬 Join a collaborative service team at the Perutz today! ➡️ tinyurl.com/5n7m2dyw

New preprint from our lab... We applied our hopping technology to relocate CTCF binding sites to thousands of alternative positions in the Sox2 locus: www.biorxiv.org/content/10.6...

Eliminating the confounding effects of human pluripotent #stemcell co-culture with MEFs: @grazianomartello.bsky.social @leeboratory.bsky.social @jzylicz.bsky.social and collaborators describe a serum coating approach for feeder-free culture of naïve hPSCs link.springer.com/article/10.1...

Serum coating enables feeder-free culture of naive human pluripotent stem cells preserving developmental potential - The EMBO Journal

Naive human pluripotent stem cells (hPSCs) represent a pre-implantation epiblast state able to efficiently differentiate into embryonic and extraembryonic pre-implantation lineages and to self-organis...

link.springer.com

I had a wonderful visit to Montpelier! Beautiful city, fantastic science! Thanks you @laghalab.bsky.social for the invitation.

Congratulations, @yinanwan.bsky.social !

Alex Schier @schierlab.bsky.social · 5mo ago

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Welcome to the campus!

Manon Demulder@manondemulder.bsky.social · 5mo ago

Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026 We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more Looking for people who want to build the lab together, get in touch! #teamtomo

The Programmable Genomics Lab at @umasschan.bsky.social just officially launched our site! We have a "simple" goal: to develop synthetic regulatory elements that target every cell type in every tissue, and control payload dosage/duration Check it out! programmable-genomics.github.io

One frame. Many voices. ✨ This International Women’s Day, our Women in Science series features group leader Christa Bücker 🙌 Today, @chribue.bsky.social shares an important perspective on finding role models and becoming one for the next generation 👩‍🔬 @univie.ac.at @meduniwien.ac.at

Today I was asked to talk at a mentoring event for people preparing an application for the ERC. Of course I spend some time on how I prepared for the successful application. However most of the time I spend on the times when it did not work out, grant was rejected.

*New pre-print* I’m delighted to share the second story from my PhD 🥳 We identify 29 severe COVID-19-associated human genetic risk variants that modulate enhancer activity in lung epithelial cells 1/10 www.biorxiv.org/cgi/content/...