We invite you to submit your latest research to our upcoming special issue: Proteostasis. This issue will be coordinated by two of our Academic Editors: Pedro Carvalho and Tamotsu Yoshimori. journals.biologists.com/jcs/pages/pr...
Elif Karagöz
@gekaragoz.bsky.social
Group leader at Max Perutz Labs interested in protein quality control
PhD position in Ribosome Biology. We look for a motivated candidate to investigate how ribosomes change during plant germination. You will join a dynamic and multidisciplinary team to apply cryo-EM, proteomics and functional assays across different model species. uni-tuebingen.de/universitaet...
PhD position in ribosome biology (m/f/d, E13 TV-L, 65%)
uni-tuebingen.de
PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs
To understand what a lipid does, we need to know its partners. Which proteins bind lipids and how can we capture those interactions? Our new Nature Protocols paper provides a practical, step-by-step guide to identifying lipid-binding proteins. 🧵
Kudos to @science.org for this self-analysis of the peer review process. These kind of data are never shared and don't have to be. Wildly refreshing to see it out in the open. Editorial and peer review dynamics at elite general science journals | Science Advances www.science.org/doi/10.1126/...
Editorial and peer review dynamics at elite general science journals
Analyses of deidentified data reveal complex interactions that quantify success at elite general science journals.
science.org
Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - UOD2336
Closing date: Thursday 27 August 2026, 23:59
dundee.ac.uk
Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...
Our work is finally out! I am extremely proud of Sanya‘s latest publication, we thank the reviewers for the amazing feedback!
Max Perutz Labs Vienna@maxperutzlabs.ac.at · 2w ago🚨 The @gekaragoz.bsky.social lab uncovers in @genesdev.bsky.social how the RNA-binding protein IGF2BP3 helps cells cope with stress by fine-tuning unfolded protein response, revealing a layer of regulation that determines if cells adapt or fail➡️ tinyurl.com/3fxhxznz @univie.ac.at @meduniwien.ac.at
Excited to see this collaboration now in print. Dye chemistry meets AI-designed proteins. Three small, orthogonal tags; lifetime modulation; split versions. Request the free dyes at dyes.janelia.org www.science.org/doi/10.1126/...
De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging
Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...
science.org
In Wilmington, North Carolina, in 1898, a white mob murdered Black men in the street and overthrew the city’s democratically elected biracial government. North Carolina would not elect another Black person to Congress until 1992. newyorkermag.visitlink.me/cRGMCD
The Intimate Legacies of a White-Supremacist Coup
A racist takeover in Wilmington, North Carolina, in 1898, has reverberated across generations as a reminder of American democracy’s terrifying vulnerability.
newyorkermag.visitlink.me
📯 Our paper “VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair” out now in Nature Communications rdcu.be/frKmN
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Nature Communications - Not all components of the lysosome damage response pathway have been defined. Here, the authors discover that the bridge-like lipid transport protein VPS13C senses lysosomal...
rdcu.be
I am excited to announce the latest paper from our lab, published in Science ! In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.
Hierarchical sensory processing in zebrafish thalamocortical-like circuits
Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian...
science.org
Kavli Institute for Systems Neuroscience@kavlintnu.bsky.social · last mo.Out now in @science.org by @emreyaksi.bsky.social, Anh-Tuan Trinh and colleagues at the Kavli Institute in Trondheim: Hierarchical sensory processing in zebrafish thalamocortical-like circuits doi.org/10.1126/scie...
Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.
I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...
My Peer Review of The 1%
I wanted to like QED's new 1% ranking. I don't.
open.substack.com
Take a look at this new paper in @science.org Reversible suppression of autophagy in a mouse model reveals neuronal resilience | Science www.science.org/doi/10.1126/...
Reversible suppression of autophagy in a mouse model reveals neuronal resilience
Impairments in intracellular quality-control mechanisms, including autophagy, affect neuronal integrity and function. Despite numerous studies aimed at slowing neuronal deterioration, it remains uncle...
science.org
🆕 publication! How do cells build their molecular machines? Tsimafei Navalayeu (Ameres lab) in @embojournal.org maps the stepwise assembly of the RNA exosome in mammalian cells, revealing the quality control mechanisms that ensure this essential complex is built correctly ➡️ tinyurl.com/84c2298e
In our latest paper in @natchem.nature.com, we reported how the crystalline environment alters protein dynamics. If you want to get the big picture quickly, have a look at the News & Views article by Lars Schäfer. www.nature.com/articles/s41... @istaresearch.bsky.social
Molecular neighbours reshape protein dynamics - Nature Chemistry
As proteins are dynamic molecular machines, to fully understand their functions we need to understand how they move. Now, nuclear magnetic resonance spectroscopy and molecular dynamics simulations rev...
nature.com
🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92
Come join the new Novo Nordisk Foundation Center for Protein Design as a group leader Cool science in a great scientific environment in wonderful and very family friendly Copenhagen There are two positions that can either be at TT assistant or associate prof level employment.ku.dk/tenure-track...
Tenure-track Assistant Professor or Associate Professor of De novo Protein Design
The Novo Nordisk Foundation Center for Protein Design at the University of Copenhagen seeks to appoint two new group leaders in de novo protein design from 1 February 2027 or as soon as possible thereafter. These positions will be at the Assistant or Associate Professor level and associated with the Department of Biology (Faculty of Science) or the Department of Drug Design and Pharmacology (Faculty of Health and Medical Sciences).
employment.ku.dk
Ina @inahuppertz.bsky.social and Kathrin @katleppek.bsky.social cordially invite all RNA enthusiasts based in the Rhineland region to attend our series of inspiring in-person talks on RNA-related topics by local and invited speakers. This time on Monday July 13th in the DZNE auditorium in Bonn.
a small attempt to capture this enormous loss and what Greg meant and means to so many. www.cell.com/cell/fulltex...
Gregory J. Hannon (1964–2026)
Gregory J. Hannon passed away in April 2026 at the age of 61. A towering figure in modern molecular biology, Greg influenced remarkably diverse areas of science. His work reshaped our understanding of...
cell.com
BacPROTACs outperform inhibitors in Mycobacterium tuberculosis https://www.biorxiv.org/content/10.64898/2026.06.12.731830v1
Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.
cell.com
So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...
LASER couples damage sensing to ESCRT assembly for lysosome repair - Nature
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
nature.com
Nature research paper: Substrate selectivity of the human RNA m5C methyltransferase NSUN2 go.nature.com/4v7ZeTt
Substrate selectivity of the human RNA m5C methyltransferase NSUN2 - Nature
NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.
go.nature.com
Single molecule studies from Arda Mizrak in the Farese/Walther @msk & Harper Labs @harvardcellbio.bsky.social shows how lipid droplet proteins track through ER networks to ultimately partition into nanodomains on droplets, dependent upon Trp-containing hairpin motifs www.nature.com/articles/s41...
Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets - Nature Cell Biology
Mizrak et al. use single-molecule tracking to dissect mechanisms of protein targeting to lipid droplets. They show that nanodomain-based confinement drives selective protein accumulation on lipid drop...
nature.com
The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox: www.nature.com/articles/s41...
Structural basis of signal peptide recognition by the signal peptidase complex - Nature Communications
Signal peptides are highly variable, yet the signal peptidase complex processes them with remarkable specificity. Here, authors combine cryo-EM, molecular dynamics simulations and modeling to reveal a...
nature.com
New insights into #fertilization from the @pauligroup.bsky.social & Ikawa labs! In a tour-de-force study, we discovered ✨ SPARK ✨, a conserved sperm fertilization complex that couples sperm-egg binding to membrane fusion. Read on 🧵👇 and check out our preprint for more details! tinyurl.com/34cm4xat
tinyurl.com
Victoria Deneke@vdeneke.bsky.social · 3mo agoHow do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇