Could not be happier for Milena!!! @maxperutzlabs.ac.at got a great one!

Max Perutz Labs Vienna@maxperutzlabs.ac.at · yesterday

Exciting news for the Perutz: @mschuhmacher.bsky.social will join the institute as a new group leader in 2027! 🎉 Currently leading an independent group at EPFL Lausanne, Milena brings an innovative chemical biology approach to lipid research ➡️ tinyurl.com/4x9xm24m

A stress response can be a great starting point for discovering new biology! By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis. Here’s the first one we characterized: www.pnas.org/doi/10.1073/...

VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1 | PNAS

Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms that protect these membranes from photooxidative damage remai...

pnas.org

Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)

Our Autumn PhD call is OPEN! 30+ fully funded positions & diverse life science subjects. Check out the openings at IMBA👉 www.vbcphd.at Apply now by 10 October! Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology

Molecular mechanism of HUWE1-HAPSTR1-USP7-mediated ubiquitin chain amplification on nuclear proteins

Molecular mechanism of HUWE1-HAPSTR1-USP7-mediated ubiquitin chain amplification on nuclear proteins

Yatskevich et al. show that HUWE1 amplifies existing ubiquitin tags through chain elongation and branching. A cryo-EM structure reveals multivalent HUWE1-USP7 assembly and reciprocal regulation, while HAPSTR1 tunes substrate capture by engaging HUWE1 ubiquitin-binding motifs, defining a coordinated system for short-lived nuclear protein turnover.

dlvr.it

How do cells remove abnormal glycogen? Led by Matthew Yip, using mouse models, cell engineering & cryo-ET, Felix Randow's group found that RNF213 ubiquitylates aberrant glycogen to trigger autophagy. https://mrclmb.ac.uk/news-events/articles/how-cells-clear-dysfunctional-glycogen/ #LMBResearch

1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...

New paper from UCSF looking at the 250 high confidence autism genes and their mechanisms of interaction in early fetal brain development www.science.org/doi/10.1126/...

Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology

Systematic mapping of protein-protein interaction (PPI) networks and determining how causal mutations rewire them in autism spectrum disorder (ASD) provide a powerful framework for uncovering disease ...

science.org

RNA dysregulation as a determinant of aging and neurodegenerative vulnerability

RNA dysregulation as a determinant of aging and neurodegenerative vulnerability

In the nervous system, aging causes deterioration of cellular and molecular processes that are associated with declines in cognition, sensory perception, and motor coordination. Aging is also the strongest risk factor for neurodegenerative disease, yet the mechanisms by which aging predisposes neurons to dysfunction remain incompletely understood. While genomic instability, proteostasis decline, mitochondrial dysfunction, and chronic inflammation have dominated prevailing models, recent evidence highlights RNA dysregulation as a central component of age-associated decline. In this review, we summarize recent findings suggesting that aging progressively erodes RNA regulatory fidelity through alterations in RNA-binding protein abundance, localization, biophysical behavior, and RNA interactions. We argue that age-dependent RNA dysregulation represents an important mechanism that converges with genetic risk to drive neuronal vulnerability and neurodegeneration.

dlvr.it

Fresh preprint from the lab: CIP2A tetramerization is required for mitotic DNA repair. A fantastic collaboration with @marcelvanvugt.bsky.social. By @laurendehaan.bsky.social, @rebeccaschneeweiss.bsky.social, and colleagues from Groningen, Vienna, Leiden, and Amsterdam 🙌 doi.org/10.64898/202...

Very excited to share our new preprint: “A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation”! 🎉 Want to know more? 🧵👇 www.biorxiv.org/content/10.6...

Congrats, Milica Mihailović from the Karagöz lab, on successfully defending her thesis titled "Dissecting the role of UFMylation in endoplasmic reticulum-associated protein quality control"! 🤩🎉 @univie.ac.at @meduniwien.ac.at

Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22

Ten years ago, our director, Stefan Jentsch, passed away. A memorial symposium will be held in his honour on October 23. Many of his former colleagues and friends will be in attendance. Would you like to join? Please register until October 1: ❕https://eveeno.com/256035281 #Ubiquitin #Symposium

🚨 Out now! Special delivery for autophagy: A new @natcomms.nature.com study from the Martens lab, led by first author Elisabeth Holzer, reveals how ATG2A and ATG8-like proteins deliver key lipids to build and expand autophagosomes ➡️ tinyurl.com/ycx9v759 @univie.ac.at @meduniwien.ac.at

🧬 New preprint from our lab! After years of work, we're excited to share our story: the pyruvate dehydrogenase complex (PDHc) — best known for feeding the TCA cycle — has a second, non-catalytic role supporting mitochondrial DNA gene expression in yeast.

Out now in @science.org Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis | Science www.science.org/doi/10.1126/...

Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis

Suppressor transfer RNAs (sup-tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTCs). Their clinical translation is limited by suboptimal ...

science.org

🎉 Our first paper from the Querques lab is out! We uncover the molecular checkpoints controlling cut-and-paste transposition by CRISPR-associated transposons. Congrats to Mateusz & the whole team! 🧬 www.nature.com/articles/s41... @univie.ac.at @meduniwien.ac.at

Max Perutz Labs Vienna@maxperutzlabs.ac.at · last mo.

Paper alert! 📢 The @irmaquerques.bsky.social lab, with Mateusz Walter as co-first author, reveals in @natcomms.nature.com the molecular checkpoints that control how and when CRISPR-associated transposons move DNA ➡️ tinyurl.com/4mzkhwz6 @univie.ac.at @meduniwien.ac.at

Paper alert! 📢 The @irmaquerques.bsky.social lab, with Mateusz Walter as co-first author, reveals in @natcomms.nature.com the molecular checkpoints that control how and when CRISPR-associated transposons move DNA ➡️ tinyurl.com/4mzkhwz6 @univie.ac.at @meduniwien.ac.at

Huge effort from the Lab into the mechanics of the mysterious #ubiquitin like protein FAT10 – taking structural snapshots of FAT10 activation by UBA6 and transfer onto UBE2Z plus really interesting insights into InsP6 regulating FAT10 conjugation pathways: www.nature.com/articles/s41...

New Online! Regulation and roles of mammalian mitophagy

Regulation and roles of mammalian mitophagy

Nature Reviews Molecular Cell Biology, Published online: 14 August 2026; doi:10.1038/s41580-026-01012-9Mitophagy contributes to cellular homeostasis through the recycling of damaged mitochondria and precise control of mitochondrial numbers. In this Review, Martens and Ganley summarize the molecular mechanisms involved in mitophagy pathways, mitophagy regulation and roles in disease.

dlvr.it

PhIX-MS is out in Molecular Cell! Rapid in situ photo-crosslinking traps transient proteasome interactions before purification; crosslinking MS, cryo-EM and AlphaFold tell us where they bind. Paper: doi.org/10.1016/j.mo... Preview: doi.org/10.1016/j.mo...

RESEARCH PAPER: Dual regulation of the unfolded protein response by IGF2BP3 during ER stress By Anisimova et al., and Elif Karagöz ➡️ https://genesdev.cshlp.org/content/40/15-16/1304.full Elif Karagöz Max Perutz Labs Vienna Universität Wien / University of Vienna MedUni Wien Vienna BioCenter

📽️ G&D Tapes 📽️ G&D Author, Aleksandra Anisimova, describes how RNA binding protein IGF2BP3 regulates effector mRNAs of the Unfolded Protein Response during ER stress. In this issue of #genesdev: ➡️ https://genesdev.cshlp.org/content/40/15-16/1304.full Elif Karagöz Max Perutz Labs Vienna

Congratulations to Yange Niu et al for showing how SIVsmm Vif was pre-equipped to antagonize human A3H-haplotype II through cryoEM and virological studies of the HIV-2 Vif-A3H complex. Another satisfying collaboration with Nicholas Chesarino and @memerman.bsky.social www.nature.com/articles/s41...

The structural mechanism of HIV-2 Vif antagonism of human APOBEC3H - Nature Communications

HIV-2 Vif counteracts a broad range of APOBEC3 restriction factors to promote viral infectivity. Here, the authors determine the structure of HIV-2 Vif bound to human APOBEC3H and the host cofactor CB...

nature.com

Check out our new @nature.com paper showing that heme scarcity is surprisingly sensed in #mitochondria by the #DELE1 pathway. Conserved all the way to Hydra, this ancient system takes the heme reading in the very organelle that produces this key metabolite. www.nature.com/articles/s41586-026-10885-x

An ancient mitochondrial program tunes translation to haem availability - Nature

An evolutionarily conserved mitochondrial haem-sensing mechanism that predates the emergence of haemoglobin-based oxygen transport could have therapeutic value in iron deficiency disorders.

nature.com

We invite you to submit your latest research to our upcoming special issue: Proteostasis. This issue will be coordinated by two of our Academic Editors: Pedro Carvalho and Tamotsu Yoshimori. journals.biologists.com/jcs/pages/pr...

PhD position in Ribosome Biology. We look for a motivated candidate to investigate how ribosomes change during plant germination. You will join a dynamic and multidisciplinary team to apply cryo-EM, proteomics and functional assays across different model species. uni-tuebingen.de/universitaet...

PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs

To understand what a lipid does, we need to know its partners. Which proteins bind lipids and how can we capture those interactions? Our new Nature Protocols paper provides a practical, step-by-step guide to identifying lipid-binding proteins. 🧵