New study from our lab at NICHD, NIH! We identify TBC1D9 and TBC1D9B as novel ARL8 effectors that suppress exosome secretion by inactivating RAB11A and thus blocking exocyst-dependent fusion of multivesicular endosomes with the plasma membrane. www.pnas.org/doi/10.1073/...

Congratulations to @juanbonifacino.bsky.social at the NIH on his election to the American Academy of Arts and Sciences — one of the nation's most prestigious honorary societies — in recognition of his distinguished contributions to cellular and developmental biology! 🎉 www.amacad.org/new-members-...

New work from Niccolo Mencacci @feinberg.northwestern.edu et al., with contribution from @depaceraffa.bsky.social in our lab at the NIH, identifies pathogenic variants in BORCS5, encoding a subunit of the BORC complex, as a cause of a severe neurodevelopmental disorder. www.jci.org/articles/vie...

Take a look at our Research Highlight: Adriana Golding et al. www.nature.com/articles/s41... We highlight the work by Ghoochani et al., who generated an atlas of brain lysosomal proteins and identified SLC45A1-associated disease as a lysosomal disorder: www.cell.com/cell/fulltex...

Our first cancer biology preprint is up! TRIM9 switches melanoma cell phenotypes. First author @klukasik.bsky.social has taken the lab into new directions for sure in a fun collaboration with @coronin.bsky.social. We can't wait to hear what you think. www.biorxiv.org/content/10.6...

Thrilled to share that the first part of my PhD work from @cohenlaboratory.bsky.social lab is now on bioRxiv! www.biorxiv.org/content/10.6... Check out the threads below:

Sarah Cohen@cohenlaboratory.bsky.social · 6mo ago

During #NeuronalDifferentiation, #organelles dramatically reorganize. #Microtubules are essential tracks for transport. But are they just highways, or can they instruct organelle behavior? Are tubulin modifications a regulatory code that guides organelle position or function? 1/9

During #NeuronalDifferentiation, #organelles dramatically reorganize. #Microtubules are essential tracks for transport. But are they just highways, or can they instruct organelle behavior? Are tubulin modifications a regulatory code that guides organelle position or function? 1/9

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 6mo ago

Tubulin acetylation governs organelle remodeling and lysosomal reformation during neuronal differentiation https://www.biorxiv.org/content/10.64898/2026.02.13.705749v1

It's such an honor to be featured in @jcb.org The Year in Cell Biology 2025 Collection!! 🤩 Huge thanks to my amazing PI @nanigrotjahn.bsky.social and my wonderful lab mate @nitishdua.bsky.social for bringing the hard copy of the magazine back from #cellbio1025 for me. It truly made my day! 🥰

Danielle Grotjahn@nanigrotjahn.bsky.social · 8mo ago

What an honor to see @attychang.bsky.social’s work featured in @jcb.org The Year in Cell Biology 2025 collection! Even more special that it coincides with my first #cellbio2025 conference 🙂 s/o to co-authors @baradlab.com @hamid13r.bsky.social @zidlab.bsky.social #teamtomo #cellbio25

Attending #CellBio2025? Come see the Cohen Lab - Monday will be a busy day for us, including my theatrical debut in WICB "Scripts of Success" skits!

1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1... Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.

Cytokines control the physical state of immune tissue

Unlike most solid-like tissues, immune tissue is protean and reconfigurable—its component cells can patrol vast territories, find rare cellular partners, and dynamically self-organize into functional ...

biorxiv.org

It was great to finish off #UNCResearchWeek by seeing Sherry Hsu’s beautiful image on display in Bondurant Hall! 🔬🔬🔬

@chrisho.bsky.social discovered exciting roles for Coro1A in netrin-dependent neuronal morphogenesis. A fun foray into a new-to-us actin regulator. rupress.org/jcb/article/...

Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis

Ho et al. identified a novel role of coronin 1A in neuronal development. They find coronin 1A mediates growth cone and filopodial dynamics, and its interac

rupress.org

I’m excited to share that my PhD work is out in @jcb.org! Big thanks to my amazing mentor @stephgupton.bsky.social and inspiring collaborator @coronin.bsky.social!!!!

Journal of Cell Biology@jcb.org · 10mo ago

Ho, @stephgupton.bsky.social et al. find that coronin 1A mediates neuronal growth cone & filopodial dynamics, & its interaction with E3 ubiquitin ligase TRIM67 is required for morphological responses to the guidance cue netrin-1 rupress.org/jcb/article/... #Neuroscience #Cytoskeleton #Development

Two weeks left to apply for this year's Physiology Course! We are looking forward to another exciting summer 🔬🦑☀️

Marine Biological Laboratory@mblscience.bsky.social · 2y ago

🔔Upcoming deadline!🔔 January 27 is the last day to submit applications to the MBL's 2025 Physiology Course. This seven-week lab course has educated generations of leading biologists and fostered groundbreaking discoveries. Learn more: bit.ly/3BZSj9c #ScienceStartsHere

Do you love #organelles? If so, vote for Cohen Lab member Sherry Hsu’s Dino-organelles in the plasmidsaurus vote below!

plasmidsaurus@plasmidsaurus.bsky.social · 2y ago

It's time to cast your vote! Which dino masterpiece will be our first 2025 winner? 🦖 Comment your choice down below! Fierce Dino Ball Drop Dinos Festive Lab Dinos Dino-organelles

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

Excited to be at #CellBio2024! Today, I'll be presenting my work exploring how the actin binding proteins and E3 ubiquitin ligases regulate neuronal morphogenesis. I'll be at poster board 40 and giving a teaser talk at 10:45 in Room 33B. Come say hi, if you love neurons, cytoskeleton or ubiquitin!

2024 Cell Biology of the Neuron GRC was rated one of the best Gordon conferences by attendees. Next stop is Italy (2026) chaired by @rkuruvi1.bsky.social & Gipi Schiavo. @barrlab.bsky.social and I will chair one after that. Attendance capped further, so don't miss it! www.grc.org/cell-biology...

Looking for the latest and greatest single particle tracking software. Please send your recommendations.

Cohen lab will be well represented at #CellBio2024! If you love #Organelles, #MembraneContactSites, and/or #Neurons and #Astrocytes, please come say hello!

I am so happy to see this finally published! Being able to manipulate Hortaea genetically has been a dream since I was a postdoc, and now it is a reality! This was possible thanks to the @mblscience.bsky.social Whitman Fellowship, which let me spend my summer studying this amazing yeast.

Strategies for genetic manipulation of the halotolerant black yeast Hortaea werneckii: ectopic DNA integration and marker-free CRISPR/Cas9 transformation | Microbiology Spectrum

Hortaea werneckii is a remarkable yeast capable of growing in high salt concentration, and its cell division cycle alternates between fission-like and budding. For these unique attributes, H. wernecki...

journals.asm.org