Subhojit Roy MD, PhD
@roylab-ucsd.bsky.social
Science & Music. Sometimes funny. www.roylab.org https://www.youtube.com/@pandemicmelodica
"Every day, we manage veterans whose conditions are profoundly complex, trauma deep, and suffering [that] can turn dangerous. This is not routine primary care; it is a form of service..." @m1singh.bsky.social 's colleague about what VA doc's life has become: www.annfammed.org/content/24/4...
Maybe I Should Have Taken the Fork
In this reflective essay, a primary care physician describes practicing within the Department of Veterans Affairs during a period of workforce reductions, policy shifts, and changing institutional pri...
annfammed.org
Twenty years ago, Addgene co-founder Melina Fan, PhD, couldn’t get the plasmids she needed for her research, so she helped build a better way to share them. 🧬 On Aug. 1, Melina stepped into a new role as Chief Scientific Advisor. A thank-you and a look at what’s next:
blog.addgene.org
Thank You, Melina: A New Chapter After 20 Years
twp.ai
"The early video store was often a place to talk as well as to shop, and the persona and expertise of retailers and clerks structured the consumer experience of home video as much as the shelves on the wall" I still have my Blockbuster card. thereader.mitpress.mit.edu/the-lost-civ...
The Lost Civic Life of Movie Rental Stores
Decades before recommendation algorithms, video stores served as social hubs where conversation and camaraderie became a form of taste-making.
thereader.mitpress.mit.edu
Key argument why academia is trash...every human "must be a strong business asset" (view shared by the mythical "requiter"):
Every trainee thinks that they can write a paper whenever they want. Some divine intervention will happen as and when necessary, but there is no need to practice anything. Newsflash: You can't just wake up one day and start writing. Just like you can't wake up one day and start playing the cello.
"For anyone with an Internet connection and a little discretionary income, the contemporary moment offers a superabundance of seductive distractions" www.theguardian.com/us-news/ng-i...
Why does everything feel so joyless? Welcome to the age of decadence without pleasure | Michèle Mendelssohn and Charlie Tyson
Decadence in our era comes in technologically mediated forms, emptied of desire and obsessed with self-optimisation
theguardian.com
"Jared Cooney Horvath said Gen Z is less cognitively capable than previous generations, despite its unprecedented access to technology...Gen Z is the first generation in modern history to score lower on standardized tests than the previous one" fortune.com/article/how-...
The U.S. spent $30 billion to ditch textbooks for laptops and tablets: The result is the first generation less cognitively capable than their parents | Fortune
Neuroscientist Jared Cooney Horvath said older generations “screwed up” giving students access to so much technology: “I genuinely hope Gen Z quickly figures that out and gets mad.”
fortune.com
Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...
Arc mediates intercellular tau transmission via extracellular vesicles
Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…
authors.elsevier.com
Interesting to see how few of the "1% papers" say something definitive with a high degree of certainty. Give me something I know is real has become gimme something fuzzy but scintillating that can go in glossy journal. I don't know how to do science anymore.
Richard Sever@richardsever.bsky.social · 2mo ago"the first validated, large-scale framework for judging the quality of life science papers independently of venue, identity, and prestige...Blinded domain-expert professors sided with score three times more often than with journal rank" the-one-percent.qedscience.com 1/n
Souvenir from the Cell Biology of the Neuron GRC in beautiful Tuscany. A great community, looking forward to meet everyone again in two years with @barrlab.bsky.social and @roylab-ucsd.bsky.social at the helm!
"But doing the minimum required just to keep your advisor or supervisor satisfied probably isn’t the goal. Hopefully, you’re motivated by more than the prospect of avoiding discipline or dismissal" helpimascientist.com/2022/11/20/h...
How hard should science trainees work? One perspective
Help I'm a Scientist - How hard should science trainees work? One perspective by David Fay
helpimascientist.com
If you use this, ask yourself: do you really like your job? 🧪
MIT Technology Review@technologyreview.com · 2mo agoPrism is a ChatGPT-powered text editor that automates much of the work involved in writing scientific papers.
"It's been 84 years but I can still smell the fresh DNA paint...." @christlet.bsky.social reminiscing with @francescabartolini.bsky.social and me at GRC Cell biology of the Neuron, Italy
A fantastic week at the Cell Biology of the Neuron GRC in Tuscany. @roylab-ucsd.bsky.social & I are organizing 2028, June 4-9: same location A great perk of being a scientist is getting to hang with other scientists. My cup is full. Thank you! @channyskye.bsky.social @rodallab.bsky.social
GRC Cell Biology of the Neuron Italy. Same venue in 2028 I'm co-chairing with @barrlab.bsky.social
"We lived below the poverty line and my stepfather [abused] my mother and me...Not long after, I escaped from our dingy apartment with a suitcase of essentials and never looked back" From homeless to Ph.D.: How I found my way into research | Science | AAAS share.google/uOXeuM5rJ7GL...
From homeless to Ph.D.: How I found my way into research
“For much of my scientific training I feared I was behind my peers,” this grad student writes
share.google
expect less hair tho...
Journal of Cell Science@jcellsci.bsky.social · 2mo agoOur Academic Editor Subhojit Roy (@roylab-ucsd.bsky.social) is attending the Cell Biology of the Neuron GRC, which takes place this week. Please reach out to him if you'd like to discuss a submission, or visit: journals.biologists.com/jcs/pages/re... #forscientistsbyscientists #notforprofit
A perfectly reasonable statement...except Barbara was not purifying tubulin. Crazy story with ups and downs shows how scientific discoveries are really made: onlinelibrary.wiley.com/doi/10.1111/...
yesterday we discussed that for a PI, every experiment takes 6 months or less because stupendous success at every corner is the norm and 18 hour workdays (including weekends) is expected.
Would you write a figure legend like this today (John Heuser 1980)? Hey, good thing we are so much more certain of our data than John was in 1980...
"No matter how much we tell ourselves AI is like spell-check, it isn’t. When we use AI to flesh out ideas, we lose the most important part of the writing process: thinking...the effort and the hang-ups are a feature of the human thought process, not a bug" www.theatlantic.com/technology/2...
The Biggest Tell That Something Was Written by AI
Look closely and you’ll see that every part of the text is not quite right.
theatlantic.com
Giving a talk? Don't waste time with "practice talks". Stay in slide sorter view & practice 3 things for each slide: 1. What point/s do I want to convey with this slide (</=3). 2. What's the 1-line summary of this slide? 3. What is the transition to the next slide? Something doesn't fit? FIX IT
"Over the last 7 yrs, we published >700 ‘First Person’ interviews...But JCS has been around much longer – in fact, JCS was first established in 1853 as the Quarterly Journal of Microscopical Science (QJMS), re-branded as JCS in 1966" @jcellsci.bsky.social journals.biologists.com/jcs/article/...
‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science
Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.
journals.biologists.com
"Intellia Therapeutics announced that its systemic CRISPR–Cas9 gene editing medicine had met primary and secondary endpoints, leading the biotech to start a rolling submission for US Food and Drug Administration approval" www.nature.com/articles/s41...
Intellia heads to FDA with first in vivo CRISPR-based gene editing therapy - Nature Biotechnology
Nature Biotechnology - Intellia heads to FDA with first in vivo CRISPR-based gene editing therapy
nature.com
"They are, after all, what our society is. A society in which it is commonplace to discriminate and other people based on religion, region, caste, class, colour of skin, gender and sexuality" www.espncricinfo.com/story/ipl-20...
Arshdeep calling Tilak 'andhera' is colourism and it is a problem, not banter
The BCCI, the IPL and the teams are supposed to check this and make the sport a more inclusive space
espncricinfo.com
I was interviewed by @snehakhedkar.bsky.social for The Scientist about our work using super-resolution microscopy to map the neuronal architecture, and make nice pictures along the way! Check the article here: www.the-scientist.com/super-resolu...
Super-Resolution Microscopy Helps Map Hidden Neuronal Architecture | The Scientist
Christophe Leterrier uses advanced microscopy to uncover neurons’ intricate nanostructure and dynamics while creating striking images that bring brain science to life.
the-scientist.com
Our postdoctoral fellow Patrick Kearney, PhD @ucsandiego.bsky.social has been selected in the Inaugural Cohort of Discovery Fellows by Aligning Science Across Parkinson’s @asapresearch.parkinsonsroadmap.org (full fellowship + research funds): parkinsonsroadmap.org/newsroom/dis...