Now out in Blood @ash.hematology.org @bloodjournals.hematology.org ashpublications.org/blood/articl... Really proud of this one, and grateful to the reviewers for the constructive criticism. It really is a much better paper now!

The red blood cell proteome and interactome identify a Band 3-BLVRB axis regulating hypoxic metabolic adaptation

Key Points. Deep proteomics defines a complete, contamination-free RBC proteome (3,775 proteins) and O2-dependent interactome by Xlinking proteomicsThe Ban

ashpublications.org

Angelo D’Alessandro@dalessandrolab.bsky.social · 8mo ago

Labor of love announcement: Red blood cells make up 83% of the cells in the human body. Mature RBCs lack nuclei (no gene expression) and organelles, and >90% of their dry weight is hemoglobin. Yet we have lacked a clean, contamination-free map of their proteome. Until now. doi.org/10.1101/2025...

Excited to share a new publications led by Dr. Cristiana O'Brien showing that circulating lipids levels can be used to predict chemotherapy response in AML patients. doi.org/10.1182/bloo...

Blood donors, like 67% of adult Americans, drink a lot of coffee. However, caffeine may reduce quality of stored RBCs by (i) inhibiting G6PD (~40%); (ii) antagonizing ADORA2b. Likely relevant beyond blood transfusion! Paper: haematologica.org/haematologic... news.cuanschutz.edu/news-stories...

Study Reveals Caffeine May Undermine Blood Transfusion Effectiveness

Study Reveals Caffeine May Undermine Blood Transfusion Effectiveness

news.cuanschutz.edu

Congratulations to Maria Amaya, MD, PhD, Assistant Professor of Medicine-Hematology (and CU HemeOnc Fellowship alumni) on being selected as one of the 2025 Translational Research Scholars. Each scholar receives research support over four years. #CUAnschutz #CUCancer

The positive economic benefit of Cincinnati Children's on Ohio is at risk cincinnatichildrenshospitalmc.us.newsweaver.com/1m1vhmv4sc/m...

This field is on fire! If you liked Julie’s poster at #ASH24, our paper just came out at Aging Cell onlinelibrary.wiley.com/doi/10.1111/...

Arginine metabolism is a biomarker of red blood cell and human aging

Reisz et al. examined age-related changes in erythrocyte metabolism using 15,700 specimens from 13,757 individuals across four cohorts, including healthy donors and sickle cell disease patients. The ...

onlinelibrary.wiley.com

Christian Frezza@frezzalab.bsky.social · 2y ago

Decoding aging clocks: New insights from metabolomics www.cell.com/cell-metabol...

Is the survival disparity observed in Black AML patients linked to underlying differences in disease biology? Come learn about PHIP, a previously overlooked oncogene found in Black patients, at my talk tomorrow (12/7) at 4:30🩸 #ASH24 #AML #healthequity @leegrimeslab.bsky.social

Excited to share two new stories investigating the importance of metabolism in AML at #ASH24! I will be presentating on 12/8 9:30-11:05am. Cristiana O'Brien will be presenting 12/8 6-8pm