🏆 Congrats to Valentina Venzin, first French researcher to win the prestigious Branco Weiss Fellowship 2026! (8 selected from 609 candidates) 🎉 She's investigating why men & women have different immune responses, unlocking precision medicine tailored to biological sex. @valentinavenzin.bsky.social

Chloé Baum @chloebaum.bsky.social leads the wet-lab team at Institut Pasteur's Biomics. With the PromethION 2 Integrated, she sequences full-length dengue & chikungunya genomes in a single read and runs 96 bacterial genomes per flow cell. #Genomics Interview ↘️ nanoporetech.com/blog/advanci...

www.cell.com/cell-host-mi... a first collaborative paper with @audeber.bsky.social @pasteur.fr - with more to come!

A family of lanthipeptides with anti-phage function

Shomar, Guillaume, et al. report the genomics-driven discovery of a family of more than 2,000 lanthipeptide biosynthetic gene clusters with anti-phage potential. They experimentally demonstrate anti-p...

cell.com

Upcoming seminar: 🎓Dr Aude Bernheim @audeber.bsky.social, Head of Molecular Diversity Unit, Pasteur Institute @pasteur.fr 📢‘What bacteria teach us about immunity’ 📅4-5 PM, Thu 6 August 📍JCBC @cambridgebiocampus.bsky.social #CITIID

In zebrafish, neural stem cells keep producing neurons throughout life. Pasteur scientists reveal how Notch3 signaling coordinates neighboring stem cells to maintain this balance, insights relevant to brain tumours. www.pasteur.fr/en/research-... @natcomms.nature.com #Neuroscience #StemCells

How Brain Stem Cells Coordinate to Produce Neurons

In many vertebrates, brain stem cells produce neurons throughout life. A team of scientists has revealed for the first time the molecular mechanisms by which adult neural stem cells communicate with o...

pasteur.fr

There is more than cilia beating in the establishment of left-right symmetry! Proud to have contributed to this beautiful study by Amaia Ochandorena Saa @meilhacsigolene.bsky.social where Thierry Blisnick imaged mouse node by SEM doi/10.1126/sciadv.adx6486 @pasteur.fr @institutimagine.bsky.social

Institut Pasteur researchers developed "optonanobody": a light-controlled nanobody targeting α7 nicotinic receptors. Switch receptors on/off with light, no genetic editing needed. New research tool for Alzheimer's, Parkinson's & schizophrenia. #Neuroscience ↘️ pubs.acs.org/doi/10.1021/...

An Optonanobody for Reversible Photoactivation of Recombinant and Native α7 Nicotinic Receptors

Photopharmacology, which enables the precise optical control of endogenous receptor activity, represents a powerful approach in neuroscience. However, photochromic diffusible ligands often exhibit lim...

pubs.acs.org

🔬 New paper in Science Translational Medicine! @science.org The complement system boosts antibody neutralization of SARS-CoV-2, especially vs immune-evasive variants. Anti-S2 antibodies + complement = better survival in severe COVID-19. 🦠🛡️ www.science.org/doi/full/10.... @martin-jg.bsky.social

Complement augments antibody neutralization of SARS-CoV-2 variants

Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.

science.org

Institut Pasteur researchers describe LIN codes in PLOS Biology: a standardized numerical system for identifying bacterial strains from genome data, now used in BIGSdb-Pasteur and Pathogenwatch for outbreak surveillance. @sylvainbrisse.bsky.social ↘️ doi.org/10.1371/journal.pbio.3003781

Life Identification Numbers: A strain nomenclature approach to aid epidemiological surveillance of bacterial pathogens

Unified bacterial strain taxonomies are needed for coherent communication of findings in microbiological research. This Essay provides an overview of a novel bacterial strain taxonomy and describes ho...

doi.org

Very happy to share a preprint on our contribution to identifying a polymerase capable of accepting heavily modified nucleotides. Great collaboration with Marc Delarue and John Chaput. Congrats to Maria! @pasteur.fr @ipdbsc.bsky.social @chem4life.bsky.social www.biorxiv.org/content/10.6...

Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical Functionality

Chemical modifications expand the functional repertoire of nucleic acids, but the extent to which complex glycans can be integrated into genetic polymers remains largely unexplored. Glycosylated nucle...

biorxiv.org

🚨 JOB ALERT🚨 We are very excited to be hiring the lab's ✨very first postdoc✨! Work on new AI technologies for decoding antigen protein evolution in a fresh research environment, at the heart of Paris 🇫🇷 Details & link to apply: research.pasteur.fr/en/job/postd... Deadline: Sep 1st

Quantifying how multiple transmission routes contribute to the spread of HTLV-1 in different endemic foci: a mathematical modelling study @scauchemez.bsky.social ↘️ www.sciencedirect.com/science/arti...

Out @cp-cellhostmicrobe.bsky.social, natural products meet bacterial immunity! We used genomics to identify lanthivirins: a family of >2,000 lanthipeptide BGCs that protect Actinobacteria against phages. Led by @hshomar.bsky.social & @mariegllm.bsky.social www.sciencedirect.com/science/arti...

A family of lanthipeptides with anti-phage function

Bacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some nat…

sciencedirect.com

L'Institut Pasteur et l'IRD ont signé ce mardi un nouvel accord-cadre de 5 ans, troisième génération depuis 2010. Priorité commune : les maladies vectorielles et zoonotiques, du laboratoire au terrain, face aux changements climatiques. 🤝 @ird-fr.bsky.social

How do commensal bacteria protect against pathogens? @jmghigolab.bsky.social lab identified CSAP-1, a pore-forming protein that mediates bacterial competition and enhances infected zebrafish survival —a promising lead for aquaculture antimicrobial strategies. 👉️ buff.ly/HSn0tLP @pasteur.fr

The brain's immune sentinels (microglia) & its protective walls (blood-brain barrier) build each other during embryogenesis. Morgane Thion's @morganethion.bsky.social G5 investigates this critical crosstalk and its role in neurological vulnerabilities. ➡️ www.pasteur.fr/en/research-...

𝗟𝗲𝘀 𝗶𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻𝘀 𝘀𝗼𝗻𝘁 𝗱𝗲́𝘀𝗼𝗿𝗺𝗮𝗶𝘀 𝗼𝘂𝘃𝗲𝗿𝘁𝗲𝘀 ! 𝗠𝗢𝗢𝗖 « 𝗦𝗰𝗶𝗲𝗻𝗰𝗲𝘀 𝗛𝘂𝗺𝗮𝗶𝗻𝗲𝘀 𝗲𝘁 𝗦𝗼𝗰𝗶𝗮𝗹𝗲𝘀 𝗲𝘁 𝗚𝗲𝘀𝘁𝗶𝗼𝗻 𝗱𝗲𝘀 𝗘́𝗽𝗶𝗱𝗲́𝗺𝗶𝗲𝘀 » 👉 Inscrivez-vous sur FUN MOOC : www.fun-mooc.fr/fr/cours/sci... 💬 Cours en français avec sous-titres (français/anglais) 📆 Accès au cours à partir du 1er septembre 2026

How do cells "hibernate"? Deep-sea archaea (100°C, 40 MPa) hold the answer. Scientists identified a protein controlling ribosome dormancy, also found in human gut archaea. Nature Communications #Archaea ↘️ www.pasteur.fr/en/press-are...

The Institut reConnect (aka Hearing Institute) at @pasteur.fr, is launching a call for applications to establish a new research group in Ear Therapy. The first stage of the process is the submission of an Expression of Interest (see details below).

Creation of a new research group – UMR Institut Pasteur/Inserm/CNRS at the Hearing Institute, Institut Pasteur, Paris  - Research

Converting advances in auditory neuroscience into innovative inner ear therapies for deafness   Major advances in the field of auditory research - particularly the development of its molecular dimensi...

research.pasteur.fr

Job Opportunity: #CNRS Chemistry - #InstitutPasteur Mid-Career Group Leader (Chemistry for Health) is open in Paris, France. This is a fantastic opportunity for a standout chemist to establish themselves in a world-class environment. research.pasteur.fr/en/call/mid-...

Mid-career Group Leader position in Chemistry for Health at Institut Pasteur, Paris - Research

Institut Pasteur and the CNRS are launching a joint call for a mid-career group leader position in Medicinal Chemistry and Chemistry for Health. We are looking for an experienced researcher (typically...

research.pasteur.fr

New paper from the team in Plos Pathogens @plos.org : providing macrophages with preferred nutrients lets Salmonella replicate even without its Type III Secretion Systems (T3SS). Work by Francisco Garcia-Rodriguez & Paula Martinez, with @kamovalenz.bsky.social and @joaquinbernal.bsky.social 🧵1/9

It was a pleasure to write this preview on the beautiful work by Clare Jolly and colleagues. Their study provides exciting new insights into how cell-to-cell transmission prepares the nuclear pore complex for HIV-1 infection. www.cell.com/cell-host-mi...

Cell-to-cell spread primes the nuclear pore for HIV-1

Cell-to-cell spread reprograms resting CD4⁺ T cells to permit infection. Mesner et al. show that contact between infected and uninfected T cells triggers CD4–LCK signaling, activating CDK1 independent...

cell.com

Very happy to share our new article published @ChemBioChem on enzymatic GalNAc-labelling of oligonucleotides. Big congrats to @pierrenicolasbizat.bsky.social and all authors! @ipdbsc.bsky.social @pasteur.fr @cnrs.fr @chem4life.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Another long-term project finally completed! Solving (well we think) the contribution of the IFT-A complex in anterograde transport. www.biorxiv.org/content/10.6... Congratulations to Adeline Mallet, Thierry Blisnick, @ebertiaux.bsky.social, Cécile Fort, Manuel Majrouh and Sylvain Trépout!

Inaugural post! We are a brand new lab @pasteur.fr studying how pathogen antigens evolve and how we can exploit these proteins' evolution to make better vaccines! Read a few words from the currently sole member of the lab @spyroslytras.bsky.social below! 😁 www.pasteur.fr/en/research-...

Predicting viral evolution with AI

Spyros Lytras is one of four young scientists selected in 2025 to lead new research groups at the Institut Pasteur. He has headed the “Antigen Evolution & Design laboratory” 5-year Group (G5) since Ju...

pasteur.fr

🚨 New pre-print alert! 🚨 Adult neural stem cell state and fate decisions are hidden within transcriptional heterogeneity. To find out how we decoded these heterogeneities to identify a molecularly encoded quiescence cycle, check out the pre-print on bioRxiv! doi: doi.org/10.64898/202...

🔬 Meet Spyros Lytras, one of our new G5 group leaders! Using AI to predict viral protein evolution, he's designing vaccines for strains that don't yet exist. No more waiting for threats to emerge—be ready ahead of time. The future of pandemic preparedness. 🧬 📖 www.pasteur.fr/en/research-...

Predicting viral evolution with AI

Spyros Lytras is one of four young scientists selected in 2025 to lead new research groups at the Institut Pasteur. He has headed the “Antigen Evolution & Design laboratory” 5-year Group (G5) since Ju...

pasteur.fr

Very happy to share our new manuscript in Bioconjugate Chemistr on the enzymatic synthesis of Glyco-DNA Equipped with Oligosaccharides and Charged Monosaccharides. Congrats to Maria and Marc! @ipdbsc.bsky.social @pasteur.fr @cnrs.fr pubs.acs.org/doi/10.1021/... pubs.acs.org/doi/10.1021/...

Enzymatic Synthesis of Glyco-DNA Equipped with Oligosaccharides and Charged Monosaccharides

The therapeutic and biotechnological utility of synthetic oligonucleotides is constrained by the limited chemical diversity of canonical nucleotides and their susceptibility to nuclease degradation. I...

pubs.acs.org

Can bacterial genomics bring 70 years of epidemiological surveillance back to life? We're hiring a postdoc (2–3 years) to explore the historical evolution of Salmonella Typhi using a unique genomic dataset. More details: euraxess.ec.europa.eu/jobs/449895

Congratulations to Shahragim Tajbakhsh on his #ERCPoC grant for StemAAV, a project aiming to target muscle stem cells for more durable gene therapies in Duchenne muscular dystrophy and other myopathies. Led with Brendan Evano @brendan-evano.bsky.social 🇪🇺👨‍🔬 @erc.europa.eu pa.eu