Robert Arkowitz
@robertarkowitz.bsky.social
Fascinated by fungal growth & asymmetries. Institute of Biology Valrose, CNRS-Inserm-Université Côté d’Azur, Nice. Microscopy addict, all things cell biological
www.nature.com/articles/s41...
IL-1 family signalling drives mucosal defence against systemic Candida albicans infection - Nature Microbiology
IL-1 family signalling drives host mucosal defence against Candida albicans and, together with neutrophils, prevents mucosal–systemic dissemination and life-threatening fungal disease.
nature.com
Happy to see this fantastic paper finally out. Started as a PostDoc in our lab and finished in her own lab at @mpi-cbg.de talented Sandra Scharaw show how intestinal stem cells optimize niche signal reception by multiple lateral Golgi stacks facing Paneth cells www.nature.com/articles/s41...
Golgi organization regulates stem cell function in the small intestine - Nature Communications
Here the authors show that intestinal stem cells reorganize their Golgi apparatus to improve the delivery of receptors that receive signals from nearby support cells. This adaptation promotes efficien...
nature.com
This one is really important. Great work! Some papers don't go on the reading list, you open them right away. 🤓 I can't help but wonder whether there's another level of regulation via acyl chain identity... the PS threshold should highly depend on saturation degree.
Abdou Rachid Thiam@abdourachidthiam.bsky.social · 9h agoA long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER membrane, which converts small lipid changes into a cooperative transcriptional response. www.biorxiv.org/content/10.6...
New imaging tools target Africa’s neglected fungal diseases www.nature.com/articles/d44...
New imaging tools target Africa’s neglected fungal diseases
A £4.5-million international initiative is developing bioimaging tools to reveal how poorly understood fungal pathogens grow and cause disease, with UCT teams focusing on infections linked to advanced...
nature.com
PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs
www.biorxiv.org/content/10.6...
Distinguishing Polymer Turnover from De Novo Biosynthesis Reveals Dynamic Cell Wall Remodeling During Aspergillus fumigatus Conidial Germination
Dynamic remodeling of extracellular matrices underlies development, environmental adaptation, and host-pathogen interactions, yet distinguishing polymer turnover from de novo biosynthesis in intact ce...
biorxiv.org
www.biorxiv.org/content/10.6...
Ire1 membrane stress responses support cell growth upon disruptions in inter-organelle contacts
Disruptions in inter-organelle contacts result in membrane lipid homeostasis defects that ultimately impair cellular function and viability. Yet, essential responses to membrane lipid imbalances remai...
biorxiv.org
Nature did a short piece on our preprint about how LLMs will affect the practice of science; my more detailed thread is below.
Scientists using LLMs will ‘do more, less well’, modelling study predicts
Research suggests that the combination of incentives to publish and the use of large language models will lead to more papers, but they will be less refined.
nature.com
Carl T. Bergstrom@carlbergstrom.com · 2w ago1. We—@eduede.bsky.social, @mjcrockett.bsky.social, Kevin Gross, and I—have a new preprint on the arXiv today, based on ideas that emerged during an @sfiscience.bsky.social workshop in November 2024: The unintended consequences of large language models as a labor-augmenting technology in science.
www.biorxiv.org/content/10.6...
Mechanochemical Feedback Enables Efficient Navigation in Complex Chemical Gradients
Neutrophils move through narrow pores, convoluted channels, and tight spaces in tissue to find infection sites. Their ability to sense weak chemical gradients, undergo directed motion, and solve such ...
biorxiv.org
Ruibao's first paper from the lab is out in @nature.com . www.nature.com/articles/s41.... Collab with @multicellgenome.bsky.social & @jennahed.bsky.social. How did cells stick together and form the first animals? The protist Ministeria suggests cellular aggregation had a role. @iuqcb.bsky.social
A unicellular relative links aggregative multicellularity to animal origins - Nature
Aggregative multicellularity was key to the evolution of the multicellular animal genetic toolkit.
nature.com
www.biorxiv.org/content/10.6...
Chaperone condensates buffer the heat shock response against pleiotropic inputs
Stress response pathways can be specific, dedicated to one stimulus, or pleiotropic, funneling distinct perturbations into a shared program. The heat shock response (HSR), the Hsf1-driven transcriptio...
biorxiv.org
www.biorxiv.org/content/10.6...
The Candida Genome Database: New Interface and New Tools
The Candida Genome Database (CGD; www.candidagenome.org) is both a model organism database and a fungal pathogen database. As a model organism database, CGD stores data for Candida albicans , which se...
biorxiv.org
🚨🚨 Faculty search! Spread the word! 🚨🚨 The Pathology, Microbiology, and Immunology Department at Vanderbilt is hiring! Special consideration will be given to faculty working with Risk Group 3 pathogens (so you can join us in our brand new state-of-the-art BSL3!) apply.interfolio.com/188545
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Yukiko Nakase, Shet Lee Ng and colleagues find that multimodal coordination of ammonium transporters helps fission yeast survive. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...
www.biorxiv.org/content/10.1...
Naegleria amoebae seek confinement and crawl persistently through narrow spaces
The ''brain-eating amoeba'' Naegleria fowleri dwells in ponds where it normally feeds on bacteria, but if it enters the brain it can cause a deadly infection. To establish infection, N. fowleri must m...
biorxiv.org
www.biorxiv.org/content/10.6...
Molecular organization of the eukaryotic secretory pathway
The eukaryotic secretory pathway is an essential subcellular network comprised of the endoplasmic reticulum (ER) and Golgi organelles. It mediates the trafficking of protein, lipid and other biomolecu...
biorxiv.org
www.nature.com/articles/s41...
Resolving endogenous protein organization in cells with nanometer resolution - Nature Communications
Eilts and colleagues combine a double-homogenisation expansion microscopy approach with dSTORM, revealing molecular details of endogenous protein complexes, including microtubules, clathrin lattices a...
nature.com
Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype
Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype
A genetic analysis in yeast establishes that multicellularity can arise as a side-effect (passenger phenotype) of a completely independent fitness advantage unrelated to the benefits of group formation...
buff.ly
www.biorxiv.org/content/10.6...
Dynamics of phosphofructokinase condensation are regulated by metabolic and redox cues
Condensation of phosphofructokinase, the rate-limiting enzyme of glycolysis, into granules has been observed across species and in various stress conditions. However, it remains unclear what mechanism...
biorxiv.org
Bacteriology-Focused Assistant Professor Position in Microbiology and Immunology at the University of Michigan Application deadline: August 15, 2026 Come be my colleague!
www.nature.com/articles/s41...
The glycolytic enzyme PGAM1 functions as a metabolic–autophagy checkpoint to coordinate growth and stress tolerance - Nature Cell Biology
Zhang, Zhao, Liang et al. report that, independent of its catalytic function, the glycolytic enzyme PGAM1 acts as a scaffold protein to regulate autophagy activation, thereby modulating cellular homeo...
nature.com
Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...
journals.asm.org/doi/10.1128/...
Lanosterol synthase inhibition as a potential approach for re-sensitizing triazole-resistant Aspergillus fumigatus | mBio
Aspergillus fumigatus is a mold pathogen and the major etiologic agent of invasive aspergillosis. Treatment of invasive aspergillosis is currently limited to only three classes of antifungals, the use...
journals.asm.org
journals.asm.org/doi/10.1128/...
Lanosterol synthase inhibition as a potential approach for re-sensitizing triazole-resistant Aspergillus fumigatus | mBio
Aspergillus fumigatus is a mold pathogen and the major etiologic agent of invasive aspergillosis. Treatment of invasive aspergillosis is currently limited to only three classes of antifungals, the use...
journals.asm.org