How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16

A huge congratulations to Zheng and the entire Guo lab for this beautiful story! Very cool mechanism! www.nature.com/articles/s41...

Intestinal stem cells count self-renewal divisions to switch multipotency - Nature

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

nature.com

Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.

Since #durotaxis was described >25 years ago, most studies report cells migrating from soft → stiff New work from my team at @ub.edu (in collaboration with D. Odde's lab) suggests we may have been missing the point all along... 🔥 Check out our new preprint here 👇 www.biorxiv.org/content/10.6...

🚨 New paper from our lab just published in Nature🚨 www.nature.com/articles/s41... Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone ✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

🚨JOB ALERT🚨PLEASE SPREAD and RT Searching for a motivated Master’s student @bokelab.bsky.social @crg.eu @prbb.org to investigate how proteostasis in oocytes influences dormancy and fertility. Reach out to me (adriano.bolondi@crg.es) to join us in sunny Barcelona! See details below👇

Interested in a PhD in collective cell migration & mechanobiology? I'm looking to support a candidate applying for a fully funded UK/Home PhD. The project studies the biophysics of migrating cells, using force measurements & optogenetics, with collaborators in Japan. #mechanobiology #PhD eb4bm.org

Home - Engineering Biology For Biomedicine

Engineering Biology for Biomedicine A UKRI:BBSRC Centre for doctoral training Why EB4BM “ Our graduates bridge fundamental biological design principles with biomedical bottlenecks, delivering engineer...

eb4bm.org

Tissue mechanics and synth morphogenesis folks, bump on this: Would you or someone in your lab be up for a video of a protocol you use getting recorded? The tips and tricks, the hard-to-explain-without-seeing-it-done? In the name of standardization and reproducibility in the field: get in touch! 🫀

Marija Matejčić (mateytch-itch)@marija-matejcic.bsky.social · 8mo ago

I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀 I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field. Abstract submission by March 2026! Get in touch✨ #JoVETissueMech #ReproducibleTissueMech

Interested in doing a PhD in tumor mechanobiology? At Université Paris-Saclay, the upcoming PhD selection process is open, and I’m looking to put forward a candidate to join my lab. If you’re excited about uncovering how mechanical signals regulate tumor progression, please get in touch!

I’m thrilled to share that I will join @gustaveroussy.fr as a Group Leader! Our objective: to understand how mechanochemical feedbacks regulate tumor dynamics and plasticity, with the overarching goal of bridging tissue mechanobiology and tumor pathophysiology using human organoids.

Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

Manning Research Group@manningresearch.bsky.social · 6mo ago

Excited to highlight a new preprint about mechanical contributions to tissue homeostasis, from the Manning group in collaboration with the amazing Carien Niessen and Sara Wickstrom @sarawickstrom.bsky.social labs, spearheaded by Dr. Somiealo Azote: www.biorxiv.org/content/10.6...

A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding

Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.

tinyurl.com

Paper alert! β-catenin forms condensates that help build cell–cell adhesions - showing its role goes beyond simply linking E-cadherin to α-cat/actin. Great collaboration with the Schuijers lab! 👉 nature.com/articles/s41...

I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀 I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field. Abstract submission by March 2026! Get in touch✨ #JoVETissueMech #ReproducibleTissueMech

Want to image cells protecting the embryo during early development? We're hiring! 1 Postdoc, 1 PhD student, and 1 Research Technician. Come to Barcelona! www.embryobioimaging.com

It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

We finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state

van der Net et al. show that mechanical interactions with the stromal component collagen I trigger reprogramming of colorectal cancer cells into a fetal-like state, through mechanosensitive integrins ...

cell.com

Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩 We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species ➡️ www.biorxiv.org/content/10.1...

➡️ This important video was missing from yesterday’s #Bluetorial. CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth. Centonze et al., in #CancerDiscovery #AACR

The Batlle Lab@batllelab.bsky.social · 10mo ago

🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...

📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now! events.ibecbarcelona.eu/embl-ibec-co...

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

On cell extrusion in the #intestine! After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report: 3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look! www.biorxiv.org/content/10.1...

New job, new preprint! We found that embryo implantation can be understood as active wetting! Embryos from older mothers have trouble implanting because they are too contractile and viscous. Check out the wonderful thread (and movies!) by @katecavanaugh.bsky.social. www.biorxiv.org/content/10.1...

A mechanical origin for implantation defects in embryos from aged females

Women over 35 experience a marked reduction in fertility. The origin of these fertility defects appears to reside in the implantation capacity of the embryo itself, but the mechanistic basis of this i...

biorxiv.org

Kate Cavanaugh@katecavanaugh.bsky.social · 10mo ago

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social : "Self-organization of tumor heterogeneity and plasticity" biorxiv.org/content/10.1... Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated? A thread👇