Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption - Cell Death & Disease

Cell Death & Disease - Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption

nature.com

Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood brain barrier disruption

Focal stroke leads to complex changes in the cerebral microcirculation in surviving brain tissues that strongly influence recovery. Plasminogen activator inhibitor-1 (PAI-1; encoded by Serpine1) is hi...

biorxiv.org

Inflammatory molecule found in the blood may underlie the link between diabetes and dementia

A study in mice identified the cytokine IL-10 as a key culprit in diabetes-associated vascular damage in the brain and cognitive deficits

peterattiamd.com

Repeated naloxone-induced morphine withdrawal alters blood brain barrier and blood spinal cord barrier integrity in mice - Molecular Brain

Passage of molecules across the central nervous system is tightly regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), which restrict entry of many substances, including op...

molecularbrain.biomedcentral.com

Capillaries susceptible to frequent stall dynamics revealed by comparing OCT and bessel-2PM measurements - Rockwell P Tang, Shannon Kelley, Gülce Küreli, Emily A Long, Piergiulio R Bressan, Shashwat S...

Transient stoppages of red blood cell (RBC) flow through capillaries—termed capillary stalls—occur persistently in neurological disorders such as Alzheimer’s di...

journals.sagepub.com

Neuroscience grad makes stroke recovery discovery - Faculty of Health - University of Victoria

A neuroscience graduate whose research focuses on improving the recovery of stroke survivors has been awarded best master’s thesis at the University of Victoria. Kamal Narayana received the Lieutenant...

uvic.ca

Retrograde and anterograde trans-synaptic viral tracing of neuronal connections reveals local and distant effects of ischemic stroke on dendritic spines - Myrthe Van Sprengel, Jenna Butterworth, Patri...

Focal stroke leads to complex neurological disturbances with variable recovery. One explanation for this variability is that stroke disrupts local and remote ne...

journals.sagepub.com

Functional and structural profiling of circulation via genetically encoded modular fluorescent probes

Sustained labeling of fluids is crucial for their investigation in animal models. Here, we introduce a mouse line (Alb-mSc-ST), where blood and interstitial fluid are labeled with the red fluorescent ...

biorxiv.org

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature

Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

nature.com

Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction

Vandal et al. performed a biological sex-based study on the role of the Alzheimer’s disease (AD) genetic factor CD2AP in brain blood vessels. Using mouse models and human AD samples, they identified a...

cell.com

APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice

Communications Biology - Lifestyle matters for genetic Alzheimer’s disease risk: In vivo imaging of mouse blood vessels and neurons shows that APOE4 reduces neurovascular function most in an...

rdcu.be

Brain Barriers

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

The pathobiology of neurovascular aging

As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only reduces cerebral blood flow but also impairs protein clearance, immune function, and neurotrophic homeostasis, thereby increasing the risk of stroke, vascular dementia, and Alzheimer’s disease.

cell.com

Hypothalamic deep brain stimulation augments walking after spinal cord injury - Nature Medicine

Whole-brain anatomical and activity surveys identify the lateral hypothalamus as a key driver of recovery from spinal cord injury, leading to a deep brain stimulation therapy that augments the recover...

nature.com

Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner

The angiogenic capacity of the mature healthy brain and its underlying mechanisms are unclear. Raudales et al. show that rates of cerebral angiogenesis follow regional gradients and are regulated by e...

cell.com

In Vivo Optical Clearing of Mammalian Brain

Established methods for imaging the living mammalian brain have, to date, taken the brain’s optical properties as fixed; we here demonstrate that it is possible to modify the optical properties of the...

biorxiv.org

Research Assistant position available in the Brown laboratory in beautiful Victoria – Canadian Association for Neuroscience

can-acn.org

Microscopy Course on iBiology

This popular, free online microscopy course begins with basics of optics, proceeds through transmitted light microscopy, and covers many microscopy methods.

ibiology.org

A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes - Nature Metabolism

Interleukin-10 promotes the formation of microcirculatory defects in the brain associated with cognitive impairment in a mouse model of type 1 diabetes.

nature.com