New paper “Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions” out in Nature Communications! doi.org/10.1038/s414...

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions - Nature Communications

Using advanced MRI modeling, this study found distinct spatial and pathophysiological signatures in vascular- and neurodegeneration-related white matter hyperintensities, clarifying their interpretati...

doi.org

It’s out! 🎉 Check our paper “Intracranial volume: To adjust or not to adjust? It is not a matter of if, but how” 🧠. We wanted to evaluate the effectiveness of different methods to adjust for total intracranial volume (TIV) to remove its effect on sex differences in aging trajectories. 1/11

Imaging Neuroscience@imagingneurosci.bsky.social · 5mo ago

New paper in Imaging Neuroscience by Aliza Brzezinski-Rittner, Mahsa Dadar, et al: Intracranial volume: To adjust or not to adjust? It is not a matter of if, but how doi.org/10.1162/IMAG...

Love seeing this paper coming out from my science neighbours @douglasresearch.bsky.social Congrats @dadarmahsa.bsky.social @albrzez.bsky.social !!

Imaging Neuroscience@imagingneurosci.bsky.social · 5mo ago

New paper in Imaging Neuroscience by Aliza Brzezinski-Rittner, Mahsa Dadar, et al: Intracranial volume: To adjust or not to adjust? It is not a matter of if, but how doi.org/10.1162/IMAG...

Job Alert! 📢📢📢 We're looking for a motivated RA with experience in histology/IHC processing: douglas.research.mcgill.ca/offres_d_emp...

Excited for this new paper in @braincomms.bsky.social by Denise Wezel and @oknox.bsky.social The association between white matter hyper intensity volume and menopausal status in the UK Biobank @linasifi.bsky.social @nikigervais.bsky.social @dadarmahsa.bsky.social academic.oup.com/braincomms/a...

Investigating links between white matter hyperintensities and menopausal status using robust age-correction methods in UK Biobank

Wezel, Parent et al. investigated white matter hyperintensity volumes across the menopausal transition in the UK Biobank using strict age-matching procedur

academic.oup.com

Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI https://www.medrxiv.org/content/10.1101/2024.05.15.24307354v1

Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI https://www.medrxiv.org/content/10.1101/2024.05.15.24307354v1

Numerous research groups worldwide have focused on postmortem imaging to bridge the resolution gap b

medrxiv.org

Postmortem MRI of Tissue Frozen at Autopsy https://www.biorxiv.org/content/10.1101/2024.01.20.576456v1

Postmortem MRI of Tissue Frozen at Autopsy https://www.biorxiv.org/content/10.1101/2024.01.20.576456v1

Introduction: Postmortem MRI provides insight into location of pathology within tissue blocks, enabl

biorxiv.org

Effects of Postmortem Intervals on Quantitative MRI in Unfixed and Fixed Swine Brain: Implications for Ex Vivo MRI Applications https://www.biorxiv.org/content/10.1101/2025.10.08.681281v1

Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II https://www.biorxiv.org/content/10.1101/2025.11.21.689744v1

Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease www.nature.com/articles/s41... via @natmed.nature.com #Alzheimers #dementia #publichealth #exercise #fitness #geriatrics #GeriSky

Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease - Nature Medicine

In cognitively normal older adults at risk for Alzheimer’s dementia, physical inactivity was associated with faster tau protein buildup and cognitive decline.

nature.com

We are excited to launch The Data Quartet Challenge, recognizing student contributions to projects that integrate data from at least 2 of 4 FRQ supported Quebec Alzheimer’s and Aging cohorts (PREVENT-AD, CIMA-Q, NuAge, TRIAD), with 3 prizes of 5000$ tinyurl.com/3dy899xn

Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | doi.org/10.1371/jour... How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates @plosbiology.org ⤵️

Integrating and interpreting brain maps | doi.org/10.1016/j.ti... Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

Hey #AAIC25 ! Today I'll be sharing our research on the mediating effect of WMH on spontaneous brain activity during aging! 🧠 Join me on poster 430! @ameliemetz.bsky.social @dadarmahsa.bsky.social @yasharneuro.bsky.social @roqamoqa.bsky.social

🧾 Poster #487 Data-Driven Characterization of Heterogeneous Brain Atrophy and White Matter Hyperintensity Progression in FTD (Amelie Metz @ameliemetz.bsky.social ) Tuesday, July 29

Honoured to have been awarded the Vanier Scholarship — pretty psyched about it. Big thanks to everyone who’s helped me get here!

McGill University@mcgill.ca · last yr.

Twenty-three #McGill doctoral & postdoctoral researchers have earned Vanier Canada Graduate Scholarships and Banting Postdoctoral Fellowships, recognizing excellence, leadership & research potential. 🔗 https://mcgill.ca/x/ist

Really excited to share this new preprint on the dynamics of alpha-synuclein spreading by Dr. Stephanie Tullo in our group. This was a long term labour of love spanning the pandemic, experimental work, and in silico modelling www.biorxiv.org/content/10.1... See more below ⬇️

In vivo and in silico alpha-synuclein propagation dynamics: The role of genotype, epicentre, and connectivity

Synucleinopathies, like Parkinson's disease (PD) are characterized by progressive accumulation and spread of misfolded alpha-synuclein (aSyn) throughout the brain. To improve understanding of disease ...

biorxiv.org

The REC Steering Committee is excited to host multiple opportunities for early career researchers across the #NIAfundedADRC Program to gather at #AAIC2025! RSVP to connect w/other scholars and leaders from #NIA, #NINDS, and the ADRC Program: uwashington.qualtrics.com/jfe/form/SV_...

In @ohbmossig.bsky.social's first Open Datasets Special Issue paper, Wearn et al. introduce the OHBM Time Machine, a freely accessible archive of Annual Meeting content on YouTube: doi.org/10.52294/001... @alfiewearn.bsky.social @sitek.bsky.social @sofievalk.bsky.social @stephforkel.bsky.social

wonderful opportunity for junior faculty

Mathew Kiang@mathewkiang.com · last yr.

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

🚨New preprint 🚨 TL;DR Supporting cerebrovascular and mental health, along with staying cognitively engaged, may help preserve brain function and delay cognitive decline and dementia. @dzne.science

medRxivpreprint@medrxivpreprint.bsky.social · last yr.

Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance https://www.medrxiv.org/content/10.1101/2025.06.16.25329648v1

After 3 years of "just one more analysis", our work on WMH pathophysiology is finally out! Building on previous post-mortem findings of non-vascular WMHs, we identified a specific signature of neurodegenerative WMHs in vivo using microstructural MRI and normative modeling doi.org/10.1101/2025...

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions

White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative e...

doi.org

Sex Differences in Vulnerability to Tau Pathology: Impact on Cognitive Decline https://www.medrxiv.org/content/10.1101/2025.05.25.25328324v1

Gray matter microstructure from in-vivo diffusion MRI reflects post-mortem neuropathology severity and clinical progression of Alzheimer's disease https://www.medrxiv.org/content/10.1101/2025.05.30.25328630v1

Vascular risk factors mediate the relationship between education and white matter hyperintensities https://www.medrxiv.org/content/10.1101/2025.06.03.25328899v1

Happy to see my first first-author paper in Imaging Neuroscience (along with @fmrib-karla.bsky.social and @nichols.bsky.social): Characterising ongoing brain aging and baseline effects from cross-sectional data doi.org/10.1162/IMAG...

Parkinson's disease links to ultra-processed foods and pesticides www.nytimes.com/2025/05/07/w... www.nytimes.com/2025/05/07/w... jamanetwork.com/journals/jam...

Chemical additives in plastics (phthalates) and cardiovascular mortality www.thelancet.com/journals/ebi...

Our Department of Global and Public Health within McGill University School of Population and Global Health is recruiting an Assistant Professor (Tenure Track). Apply now! 👇 mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Reducing the risk of all-cause dementia with intensive blood pressure control, the results of a cluster randomized trial in~34,000 participants. @naturemedicine.bsky.social www.nature.com/articles/s41...

Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial - Nature Medicine

In the CRHCP-3 cluster-randomized trial, blood pressure reduction lowered the risk of all-cause dementia by 15% in 33,995 individuals with hypertension.

nature.com