I'm looking for an enthusiastic student to join my team as a PhD candidate on archaeal genome evolution 🦠💻 Work in beautiful Utrecht, at @binfutrecht.bsky.social, an international group full of caring, amazing scientists, and with frequent cake breaks! www.uu.nl/en/organisat... Please share! 🙏

New review in @cp-trendsgenetics.bsky.social on the fascinating world of chromatin organization in Asgard archaea. Very nice joint effort with @jvhooff.bsky.social www.sciencedirect.com/science/arti...

Chromatin organization in Asgard archaea: histones, SMC complexes, and the archaeal roots of eukaryotic chromatin

The genomes of organisms across the tree of life are structurally and functionally organized into chromatin. In eukaryotes, within an organelle called…

sciencedirect.com

Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com www.jobs.ac.uk/job/DQY475/r...

Research Fellow (Postdoctoral) at University of Birmingham

Explore an exciting academic career as a Research Fellow (Postdoctoral). Don't miss out on other academic jobs. Click to apply and explore more opportunities.

jobs.ac.uk

Now online! Bringing the genetically minimal cell to life on a computer in 4D

Bringing the genetically minimal cell to life on a computer in 4D

Simulating the complete cell cycle of the minimal cell provides a platform to understand the progression of complete states over time. The spatial heterogeneity of the intracellular environment can strongly affect biochemical reactions that control phenotypes.

dlvr.it

Now online: Pingzhuang Ge's studies on the impact of pH on local chromatin structure and transcriptional activity of the H-NS-regulated hdeAB operon www.biorxiv.org/content/10.6...

Mark your calendars for the next incarnation of the Biology and Physics of the Prokaryotic Chromosome meeting to be held in Paris on July 6-9, 2027. See the web site for further information biophychrom2027.sciencesconf.org

pdb101.rcsb.org/motm/314

PDB101: Molecule of the Month: Histones Across the Tree of Life

Uncovering the evolutionary diversity of histones

pdb101.rcsb.org

My laboratory has an open postdoctoral position in the field of biomolecular condensate mechanochemistry! Please inquire if you are interested in interdisciplinary, cutting-edge research! www.mashaghilab.org/vacancies (Deadline: February 8, 2026) #ChemSky #Mechanobiology #Biomolecular_Condensate

Mashaghi Lab - Vacancies

Community science: Since 1996, Alireza Mashaghi has actively advocated for collaborations between disciplines to explore new ways of addressing scientific and societal challenges. The team has a long...

mashaghilab.org

I am very pleased to share that our database of prokaryotic and viral histones, ProHistoneDB, is now available online at prohistonedb.org. Please also see the accompanying article in J Mol Biol: doi.org/10.1016/j.jm...

We invite contributions to a special issue on "Chromatin Structure and Function in Bacteria and Archaea," edited by Ilaria Baglivo and me. See: www.mdpi.com/si/264656

I am very pleased to share our newest work on the face-to-face histone HTkC, which plays an important role in chromatin organization next to canonical histones HTkA and HTkB www.biorxiv.org/content/10.6...

Archaeal histone HTkC hypercompacts DNA

Histones are important organizers of chromatin in eukaryotes and archaea. In eukaryotes, the core histones assemble with DNA to form the octameric nucleosome. In archaea, histones form hypernucleosome...

biorxiv.org

Let’s wrap things up: Open and closed hypernucleosomes in Asgard archaea

Let’s wrap things up: Open and closed hypernucleosomes in Asgard archaea

Asgard archaea are widely considered the closest living relatives of eukaryotes. In this issue of Molecular Cell, Ranawat et al. report high-resolution structures of hypernucleosomes formed by the hodarchaeal HHoB histone, disclosing open and closed chromatin conformations.

dlvr.it

New article online: Modulation of archaeal hypernucleosome structure and stability by Mg2+ In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB). www.sciencedirect.com/science/arti...

Modulation of archaeal hypernucleosome structure and stability by Mg2+

DNA-wrapping histone proteins play a central role in chromatin organization, gene expression and regulation in most eukaryotes and archaea. While the …

sciencedirect.com

Soon available in my group: 1 PhD position to investigate prokaryotic histones. See our recent work that highlights the existence and diversity of prokaryotic histones (e.g. Schwab et al., TIBS, 2025; Schwab et al., Nat Comm, 2024; Hu et al., Nucl Acids Res, 2024). Please DM for informal enquiries.

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

That’s a wrap for The Biology and Physics of Prokaryotic Chromosomes VII 2025. A big thank you to all those who attended 🧪 #BioPhyChrom2025 #BiochemEvents

Tomorrow is the start of Biology and Physics of Prokaryotic Chromosomes VII. Great speakers and participants. Excellent support by the Biochem. Society. @biochemsoc.bsky.social @danielabarilla.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @damelab.bsky.social #BioPhyChrom2025

Time flies .. it is today 25 years ago that we published our studies that revealed that bacterial H-NS is a DNA bridging protein: academic.oup.com/nar/article/... @narjournal.bsky.social

H-NS mediated compaction of DNA visualised by atomic force microscopy

Abstract. The Escherichia coli H-NS protein is a nucleoid-associated protein involved in gene regulation and DNA compaction. To get more insight into the m

academic.oup.com

One week to go for The Biology & Physics of Chromosomes VII, but there is still time to register! Join us! 🧬🧬🧬 @biophychrom.bsky.social @biochemsoc.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @damelab.bsky.social

Daniela Barillà@danielabarilla.bsky.social · last yr.

Chromosome enthusiasts, York is calling! Join us at The Biology & Physics of Chromosomes www.eventsforce.net/biochemsoc/f... Late breaking abstract deadline 📆 7 August @biophychrom.bsky.social @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social #microsky

Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...

Supervisors and Projects

bioch.ox.ac.uk

Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫 www.eventsforce.net/biochemsoc/f... @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

Just few days left to register for this chromosome biology fête! 🧬🧬🧬 ⏳📆 16 July www.eventsforce.net/biochemsoc/f... @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

I am pleased to share our new review on the role of bacterial nucleoid-aasociated proteins in mediating responses to changes in environment. Important: some NAPs can directly ‘sense’ physico-chemical changes. www.sciencedirect.com/science/arti... @pingzhuangge.bsky.social

The role of nucleoid-associated proteins in mediating responses to environmental changes

Bacteria face diverse environmental challenges, such as changes in temperature, pH, and osmolarity, and exposure to antibiotics, which necessitate ada…

sciencedirect.com

York calling! 📣 🧬🧬🧬 Join us at www.biochemistry.org/events-and-t... ⏳⏰ Early bird deadline approaching soon, 16 July! Do not miss out! Half of the talks selected from abstracts. @damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

Daniela Barillà@danielabarilla.bsky.social · last yr.

Fancy a journey back in time to Roman Eboracum by walking on the city walls?And a visit to the Norman Clifford Tower? A stroll down the Middle Age Shambles? All this whilst enjoying a full immersion into chromosome biology? 🧬 Join us at The Biology & Physics of Prokaryotic Chromosomes! 🦠🧪🧬

A must-read for histone afficionados: our new review on 'Histone-mediated chromatin organization in prokaryotes and viruses' www.cell.com/trends/bioch... @samuelschwab.bsky.social @vikramalva.bsky.social

Histone-mediated chromatin organization in prokaryotes and viruses

Histones are fundamental chromatin-organizing proteins in eukaryotes and archaea, where they assemble into (hyper)nucleosomes that wrap DNA. Recent studies have expanded the known repertoire of histon...

cell.com

Chromosome Enthusiasts, join us at The Biology & Physics of Prokaryotic Chromosomes 🧬! Friendly community, fantastic speakers line-up, grant writing session for ECRs. Early-bird deadline approaching soon. @damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biophychrom.bsky.social

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

Join us in York for the Biology & Physics of Prokaryotic Chromosomes! 🧬 #Microsky #Archaeasky www.biochemistry.org/events-and-t... @biochemsoc.bsky.social @damelab.bsky.social @graingerlab.bsky.social @vslioy.bsky.social

Daniela Barillà@danielabarilla.bsky.social · last yr.

Fancy a journey back in time to Roman Eboracum by walking on the city walls?And a visit to the Norman Clifford Tower? A stroll down the Middle Age Shambles? All this whilst enjoying a full immersion into chromosome biology? 🧬 Join us at The Biology & Physics of Prokaryotic Chromosomes! 🦠🧪🧬

New vacancy in my team! PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture. Please repost and share with talented MSc students in #evobio, bioinformatics or related :) www.uu.nl/en/organisat... #MEvoSky #MicroSky