Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil

A fantastic #postdoc opportunity to join us in Dresden @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social or to join @biohub.org. Apply by the 20th of May!

Max Planck Institute of Molecular Cell Biology and Genetics@mpi-cbg.de · 3mo ago

Biohub @biohub.org and @maxplanck.de, represented by @mpi-cbg.de and @mpipks.bsky.social, invite applications for the Global Science Scholars program, a three year international postdoctoral fellowship program between the U.S. and Germany. www.czbiohub.org/program-mpi-...

@lsprahl.bsky.social and Ronald Canlla in the lab just published a detailed study on remote-controlled epithelial budding morphogenesis. We can direct budding, tubule elongation, and perhaps branching in human kidney organoids via a light-activated RET receptor. www.biorxiv.org/content/10.6...

*New preprint alert* uncovering a mechanical pacemaker that synchronizes nephron formation with branching of the kidney's epithelial tubule tree. Read below to learn about this twisty journey lead by Sam Grindel and Sachin Davis in the lab. [Movie by Nils Lindstrom] www.biorxiv.org/content/10.1...

if you are attending #CellBio2025 please check out the posters from our lab @hugheslabpenn.bsky.social. The lab will have a great showing this year featuring my talented colleagues @lsprahl.bsky.social @danielalber.bsky.social and many others!

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

How do cells navigate up gradients of adhesive proteins? 🤔 Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood We show that passive friction directs cells & explains complex trajectories on gradients 👉 www.nature.com/articles/s41...

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

Peer pressure shapes the gut: latest publication in @pnas.org by @lepuslapis.bsky.social, @zhaoshh.bsky.social from @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social with colleagues from @flatironinstitute.org and Princeton University. www.mpi-cbg.de/news-outreac...

Peer pressure shapes the gut

International research team develops mechanical model to explain the shaping of the fruit fly hindgut by forces from neighbouring tissues

mpi-cbg.de

Now #published @pnas.org: "A model for boundary-driven tissue morphogenesis", a great #biophysics #devbio collaboration led by @danielalber.bsky.social @zhaoshh.bsky.social: doi.org/10.1073/pnas.2505160122 @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social @flatironinstitute.org

Pierre Haas@lepuslapis.bsky.social · last yr.

New #preprint: "A model for boundary-driven tissue morphogenesis" arxiv.org/abs/2503.03688. A great collaboration with @danielalber.bsky.social @zhaoshh.bsky.social, Alexandre Jacinto, Eric Wieschaus, Stas Shvartsman. @flatironinstitute.org @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia. @sreejithsanthosh.bsky.social biorxiv.org/content/10.1...

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

Now #published in Phys. Rev. Lett. as an Editors' Suggestion: "Mechanics of poking a cyst" - the first paper from the PhD work of @zhaoshh.bsky.social. journals.aps.org/prl/abstract... @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...

Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous

For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...

science.org

How do cells migrate without substrate, e.g. in embryogenesis, when extra-cellular matrix has not yet formed? Check out our paper in @cp-cellreports.bsky.social on zebrafish lateral mesendoderm migration, led by @stetavano.bsky.social @heisenbergcplab.bsky.social! www.cell.com/cell-reports...

Ste Tavano@stetavano.bsky.social · last yr.

That is a great reason for a first post! With a few days of delay, I am proud to share that my postdoc work at the @heisenbergcplab.bsky.social has finally been published on @cp-cellreports.bsky.social doi.org/10.1016/j.ce... Now a small (or maybe not) thread about the work!

I am delighted to share with you my first postdoc paper, which has now been published in @currentbiology.bsky.social! www.cell.com/current-biol... Thanks to everyone who contributed: A. Chamolly, @aurelienvilledieu.bsky.social, F. Corson and @jeromegros.bsky.

A tension-induced morphological transition shapes the avian extra-embryonic territory

Michaut et al. show that the tension produced during epiboly elastically stretches the extra-embryonic (EE) territory, while the embryo proper (EP) remains unaffected. Although the whole epiblast (EP ...

cell.com

New #preprint: "Euler buckling on curved surfaces" arxiv.org/abs/2503.04303 @zhaoshh.bsky.social and I ask the question that Euler left open: How does an elastic line buckle within a (general) curved surface? @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

New #preprint: "A model for boundary-driven tissue morphogenesis" arxiv.org/abs/2503.03688. A great collaboration with @danielalber.bsky.social @zhaoshh.bsky.social, Alexandre Jacinto, Eric Wieschaus, Stas Shvartsman. @flatironinstitute.org @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

Developmental systems have regions that deform actively or passively from their active neighbors. We use a ring of tissue as a model to investigate this boundary-driven morphogenesis in its biological context, learning something about gastrulation and possibly blastopore geometries in the process!

Pierre Haas@lepuslapis.bsky.social · last yr.

New #preprint: "A model for boundary-driven tissue morphogenesis" arxiv.org/abs/2503.03688. A great collaboration with @danielalber.bsky.social @zhaoshh.bsky.social, Alexandre Jacinto, Eric Wieschaus, Stas Shvartsman. @flatironinstitute.org @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron). We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.