We found maternal helminth infection can promote antiviral immunity in offspring 🤱🪱 www.cell.com/cell-host-mi... Don’t worry, we are not suggesting we reinfect everyone with worms! Instead, we identified a microbiota-derived metabolite, Indole-3-propionic acid, that enhances antiviral immunity!

Maternal helminths rewire the microbiota to promote offspring antiviral immunity

Fernandes et al. show that maternal helminths, long-standing mammalian partners, confer antiviral immunity to offspring via the microbiota-derived metabolite indole-3-propionic acid (IPA). This work r...

cell.com

If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️ We are looking for a postdoc to join our team at @imbavienna.bsky.social More details 👇🏻

Institute of Molecular Biotechnology@imbavienna.bsky.social · 5mo ago

We are hiring! Join the Jachowicz lab as a postdoctoral researcher. The project focuses on understanding the dynamics of ncRNAs using high-resolution and single-molecule microscopy approaches. Link below 👇

Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus. www.science.org/doi/10.1126/...

Hybrid female sterility due to cohesin protection errors in mouse oocytes

Misregulation of chromosome cohesion during female meiosis serves as a reproductive isolating barrier in mice.

science.org

Looking for motivated postdocs interested in doing exciting research at the intersection of immunology and regenerative biology. We use intravital two-photon imaging to track and manipulate immune cell behavior at the single-cell level in live animals mesa-lab.org Apply: apply.interfolio.com/180660

Mesa Laboratory

mesa-lab.org

Delighted to share my PhD work with @schuhlab.bsky.social @mpi-nat.bsky.social on #humaneggrejuvenation, now available as a preprint on @biorxivpreprint.bsky.social 🎉 Grateful to my collaborators for the teamwork and support 🙌 More details here 👇 www.biorxiv.org/content/10.6... #Aging #Aneuploidy

Restoring Shugoshin 1 reduces chromosome errors in human eggs

Aneuploidy in human eggs, which rises sharply with age, is a leading cause of infertility, IVF failure, and miscarriage. This age-related aneuploidy is primarily driven by premature sister chromatid s...

biorxiv.org

Schuh Lab@schuhlab.bsky.social · 7mo ago

Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility. Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it. www.biorxiv.org/content/10.6... (1/10)

Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility. Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it. www.biorxiv.org/content/10.6... (1/10)

Really happy to see my PhD first-author paper published in @nature.com! I’m very grateful to have worked with such a great team. Huge thanks to Urša Uršič, Michael Staddon, and Jan Brugués, as well as the @brugueslab.bsky.social, and the @poldresden.bsky.social and @mpi-cbg.de community!

Brugues Lab@brugueslab.bsky.social · 7mo ago

Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

📣Huge congrats to our postdoc, Takaya Totsuka, on his new paper @currentbiology.bsky.social 🎉 He found that Ca2+ oscillations regulate oocyte spindle rotation! 🐭The project started during his PhD with Prof. Miho Ohsugi. Free link: authors.elsevier.com/c/1lUqk3QW8S...

🔊New preprint from our lab! Zygotene cilia regulates meiosis, germ cell development, and fertility in zebrafish, mice, and humans www.researchsquare.com/article/rs-7...

LIMmunity is growing! 🤰🤱👶 We are looking for curious & driven postdocs to join us at @princetonmolbio.bsky.social & HHMI to explore the fascinating world of maternal-offspring immune partnerships! Come be part of our collaborative team! hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Postdoctoral Scientist- Lim Lab

Primary Work Address: Dept of Molecular Biology, Princeton, NJ, 08544 Current HHMI Employees, click here to apply via your Workday account. The Lim Lab at Princeton University is seeking an energetic,...

hhmi.wd1.myworkdayjobs.com

Mathematical modelling of the first fate decision This Research Highlight showcases the work from Maria Avdeeva, Madeleine Chalifoux, Bradley Joyce, Stanislav Y. Shvartsman, Eszter Posfai @eposfai.bsky.social : journals.biologists.com/dev/article/...

our unexpected results on the importance of a neural cell adhesion molecule in sea anemone epithelialization and gastrulation are just posted in the following preprint. www.biorxiv.org/content/10.1...

Depletion of a neural cell adhesion molecule disrupts both epithelial and germ layer identity in sea anemone embryos

Assembly of cells into epithelial layers marks the early steps of tissue organization and embryonic development in most animals. Although several conserved proteins are known to be essential for epith...

biorxiv.org

The #devbio project that encompassed the majority of my postdoc is finally out! Huge thanks to my coauthors and our collaborators without whom this work would not have been possible, and my adviser Eszter Posfai who let me play with a light sheet microscope and some colorful mice :)

Eszter Posfai@eposfai.bsky.social · last yr.

Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!

Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!

pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...

We’re hiring! Our lab at WashU has an opening for a Senior/Staff Scientist position. If you're passionate about ovarian physiology, oocyte quality, and excited to contribute to a dynamic and growing team, we’d love to hear from you! Reach out to me directly for more information.

Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...

For my first science post here, I’m proud to advertise our latest work exploring why germ cell connectivity is really important for meiosis 🐁 Done with some awesome colleagues @florpratto.bsky.social www.nature.com/articles/s41...

Intercellular bridges are essential for transposon repression and meiosis in the male germline - Nature Communications

A conserved feature of metazoan meiosis is that it occurs in a syncytium. Here, the authors show that intercellular bridges that connect germ cells in a syncytium are critical for ensuring proper meio...

nature.com

How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...

Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous

For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...

science.org

Interaction between two cells is necessary and sufficient to initiate PCP sorting😀, as shown by Lena P. Basta, Bradley W. Joyce, Dr. Eszter Posfai @eposfai.bsky.social , and Dr. Danelle Devenport. Here is the article. www.science.org/doi/10.1126/...

Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous

For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...

science.org

A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron). We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.

Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags! www.biorxiv.org/content/10.1...

An intriguing mechanism of germline cyst formation through innovative live imaging in fetal mice gonads, and computational modeling. Check out my dispatch in @currentbiology.bsky.social on this beautiful work. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Fascinating & unexpected from the Rodriguez lab on cell competition acting as a nutrient sensor Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them Explains old observations that starvation prevents competition www.biorxiv.org/content/10.1...

Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition.

Cell competition is a quality control acting from development to the adult that eliminates cells that are less-fit than their neighbours. How winner cells induce the elimination of losers during this ...

biorxiv.org

Sharing my latest preprint as a re-introduction to bsky! biorxiv.org/content/10.1... ---- Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?

Check out our new paper in @currentbiology.bsky.social by amazing grad students @ezlevy.bsky.social and @isabellaleite.bsky.social “A tug-of-war between germ cell motility and intercellular bridges controls germline cyst formation in mice” authors.elsevier.com/a/1k7fg3QW8S...