'Fast and slow skeletal muscle: Different overall activation levels and kinetics of myosin motors underlie muscle type-specific contractile properties' Daniel Z. Kruse from @au.dk et al. examine the work of Hill et al. (2026) in this #JournalClub 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

We are ready to scale up glycogen analysis using electron microscopy. By applying a new AI-based image analysis pipeline, workload for 50 samples was reduced from ~600 hours to ~20 hours. This moves us beyond small-scale TEM studies. Details below 👇

First preprint from my PhD! www.biorxiv.org/content/10.1... We show that piperine: 1️⃣ increases ON myosin in resting skeletal muscle. 2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner @hesselanthony.bsky.social

Piperine activates the thick filament of resting rat skeletal muscle, enhancing dynamic contractility in a fiber-type-dependent manner

Thick-filament activation, whereby myosin heads transition from an OFF to an ON state, is a key regulatory step in muscle contraction and a promising therapeutic target. The availability of ON-state m...

biorxiv.org

Excited to share our preprint using time-resolved small-angle X-ray diffraction to study myosin motor conformations during isometric twitch and tetanus contractions in the slow-twitch rat soleus skeletal muscle #myoblue

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 12mo ago

Distinct distributions of myosin motor conformations during contraction of slow and fast skeletal muscle https://www.biorxiv.org/content/10.1101/2025.10.13.679501v1

I have had the fun (and challenging!) opportunity to explain some of my PhD research to a general audience. Thanks to @apsphysiology.bsky.social!

American Physiological Society@apsphysiology.bsky.social · last yr.

Do fast cars burn more fuel? What if you swap out the engine? Your muscles work the same way—and in this case, the "engine" is a compound found in black pepper. @danielzkruse.bsky.social breaks it down on the #ISpyPhysiology blog: ow.ly/OQSQ50WATn9 🧪

New publication on #muscle stretch-shortening cycles. Elst et al. (2025). Eur J Physiol rdcu.be/elxuN @neuromechahnics.bsky.social , @myoblue.bsky.social

Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes

Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia

Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...

link.springer.com

@ambiotech.us on the lookout to hire some #MuscleScientists on a short-term, muscle small-angle X-ray diffraction project in June / July in NY. Must have work permission in USA and must have permeabilized fiber mechanics experience. X-ray experience not mandatory. Full travel plus pay. DM me!

Just completed our first x-ray diffraction experiments at the PETRA III beamline in Hamburg - what an experience! Intense night shifts with cool science on sarcomeric structures in skeletal muscle 💪🏼 Can’t wait to get into the results! Thanks to @hesselanthony.bsky.social and @ambiotech.us