4-1BBL on monocyte lineage cells rather than on classical dendritic cells drives CD8+ T cell accumulation in the respiratory tract and protects from severe respiratory influenza infection: www.mucosalimmunology.org/article/S193...
Dan Tyrrell
@danis1337.bsky.social
Asst. Professor at UAB Pathology | T cells, aging, mitos, 🧠,🫀, ☕️, 🐭, 🔬, data vis | He/him | Views mine
CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer Interesting stuff on CD8 T cells www.cell.com/cell/abstrac...
CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer
Dusp5 and Zfp219 serve as critical regulators of age-related T cell dysfunction, with the loss of either driving T cells into an effector-like state that improves tumor control through distinct mechan...
cell.com
A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice Really interesting doi.org/10.1126/scit...
A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice
Mitochondrial uncoupling limits atheroprogression by improving insulin sensitivity, lowering triglycerides, and suppressing inflammasome activation.
doi.org
Not everyone uses AI for their emails yet. Just got a “Greetings of the day!”
Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter Nice paper from Marissa Schafer's group in Nature Aging: doi.org/10.1038/s435...
Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter - Nature Aging
Carver and colleagues profile the aged mouse brain using spatial transcriptomic and imaging analysis and identify a senescence- and disease-associated microglial-linked state enriched in white matter ...
doi.org
gap in knowledge? gaping hole in our collective biological heart we really need some better prose in our grant applications
Is it allowed for fans to bring a full size trombone into the stadium for the World Cup?
I’m soooo excited to get the NOA for the lab’s first R01! Great work from the whole team!
Great American State Fair in DC seems like a cry for DC statehood
#EndothelialCell #PlanarCellPolarity Mutated in Colorectal Cancer BioID interactome in EC▶️ Centriolar proteins +ROBO1 KEAP1 p62 EC MCC KO🐭Retina ⏬Vascularity ⏬Engaged sprouting tip cells (cell body orientation perpendicular to migration front) #Angiogenesis 2026 link.springer.com/article/10.1...
Never 3D printed anything in my life but I think I should do it. Anyone ever followed through to see if these conferences are real?
This is amazing
Richard Sever@richardsever.bsky.social · last mo."public trust in science and scientists is high...The idea that there’s a pervasive lack of trust is completely unfounded...But trust has dropped in certain groups...politically right-leaning groups" Maybe it's not science/scientists that's to blame... 1/2 www.nature.com/articles/d41...
There’s a mosquito in my office and I can’t find it. This is my nightmare
This is so dumb. Pluto is NOT a planet!
Gabino Iglesias@gabino.bsky.social · 2mo agoIt’s always okay to make fun of flat earthers.
3D reconstruction reveals highly conserved vascular network architecture despite phylogenetic diversity spanning >300M years of evolution. Moer here: www.biorxiv.org/content/10.6...
Mechanical perturbation (pipetting) & Reassembly of 🐭colon epithelial organoids😎 Mimicking acute colon injury with epithelial contact/barrier disruption Organoid size-dependent effects of IL-11-JAK/STAT3 axis🤠 @takashi-nishina.bsky.social bioRxiv 2026 www.biorxiv.org/content/10.6...
We are happy to share another paper from the lab! Led by Lena Gaebel, using unconditioned adoptive cell transfer and congenic tracking, we show that Tet2 or Jack2 clonal hematopoiesis do not modify murine tauopathy. journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
What’s unique about NIH programs is the rigorous evaluation. Where else do you find a new career training program with 20 year follow up? We hope business leaders and NGOs take note of the methods!
NIH diversity programs doubled undergraduates’ odds of getting a Ph.D., 20-year study finds
A new study found that two diversity-oriented programs supported by the NIH doubled the odds that an undergraduate would earn a Ph.D.
statnews.com
Wow Plasma proteomic signatures of cellular aging predict human disease Cool doi.org/10.1038/s415...
Plasma proteomic signatures of cellular aging predict human disease - Nature Medicine
The biological age of individual cell types can be evaluated using plasma proteomics, revealing diverse aging profiles across more than 40 cell types and links between the accelerated aging of specifi...
doi.org
IFN-γ produced during immunotherapy induces PD-L1 expression by neutrophils with an aged phenotype that drives therapy resistance @cp-immunity.bsky.social @ki.se www.cell.com/immunity/ful...
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis. Cool work from Cam McAlpine’s group doi.org/10.1038/s415...
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis - Nature
Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.
doi.org
Smooth Muscle Cell Calcification (Cultured & in vivo +VitK+Warfarin) is associated Depletion of Hyaluronan ⏬HAS1 HAS2 TSG-6 ⏫HAS3 Versican Very interesting study! But some data needs to be scrutinized...🤔 #Biomol_MDPI 2026 www.mdpi.com/2218-273X/16...
#ArterioVenousMalformation #HereditaryHemorrhagicTelangiectasia Endothelial Cell KLF4 hyperactivation➡️ ⏫EC Proliferation ⏬EC PDGFB➡️ ⏬NG2+PDGFRβ+ Pericyte investment on AVM lesion Evidence from 1⃣🐭 Retina +BMP9/10 Ab +EC Alk1 or Smad4 KO 2⃣HHT2👤 Nasal mucosa #THNO 2026 www.thno.org/v16p4905.htm
another grant app sent off to the void. we collectively keep pumping these out. is there a point to this?