Paul Dark
@darknatter.bsky.social
Healthcare professional, educator and researcher, Manchester, UK https://research.manchester.ac.uk/en/persons/paul.m.dark 🇬🇧 🇨🇭
anway, read @iwashyna.bsky.social in @nejm.org I look forward to the day when we know better when to start empiric antifungals I'm sure there will be some frustrating BPA popups during the transition but if we can take better care of patients, lets do it
Choosing Humility in the Face of My Ignorance
A patient in shock forced me to consider how to respond to the limits of my own knowledge and those of the medical field at large.
voices.nejm.org
Over on LinkedIn, @darknatter.bsky.social wrote: "Thanks Jack, enjoyable read and hard hitting truths on clinical uncertainty. We've been pondering the "antifungal overuse" question in this setting - the other side of the same coin. Thankfully, research funding is still accessible ...
The team has been in conversation with fellow delegates about rapid diagnostics for sepsis, clinician and nursing care and potential charity partnerships. A chance also to reconnect with @darknatter.bsky.social Prof. Paul Dark, whose continued support for Sepsis Research FEAT's work is invaluable.
Clinical effectiveness of procalcitonin- or C-reactive protein-guided antibiotic discontinuation protocols for adult patients who are critically ill with sepsis: a rapid systematic review and meta-analysis www.manchester.ac.uk/about/news/t...
Test shows when safe to stop antibiotics in sepsis patients
A simple blood test can tell doctors when it is safe to stop antibiotics in patients recovering from sepsis, a review led by University of Manchester researchers has found. The review including 21 stu...
manchester.ac.uk
Cost effectiveness of PCT-guided antibiotic duration explored link.springer.com/article/10.1...
Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis - Critical Care
Background Procalcitonin (PCT)-guided antibiotic duration for critically ill adults with sepsis may be clinically effective and safe. However, cost-effectiveness analyses using clinical trial data for...
link.springer.com
As @ics-updates.bsky.social updates #SOA25 congress draws to a close in Birmingham, Professor Paul Dark @darknatter.bsky.social of manchester.ac.uk emphasises the importance of this charity’s priority setting exercise in ensuring that patient needs are addressed by future sepsis research programmes
New from @jomcpeake.bsky.social @iculone.bsky.social @darknatter.bsky.social and colleagues from @sepsisresearch.bsky.social the full publication of the Sepsis Research priorities. These set out the research priorities from established sepsis survivors, families, carers and healthcare professionals
Top 10 research priorities for sepsis research determined by patients, carers and clinicians
Introduction Sepsis is a high burden syndrome associated with increased morbidity and mortality in both the acute and longer-term phases of illness. Multiple treatment uncertainties remain that requ.....
doi.org
Please consider responding to this important survey following on from publication of the ADAPT-Sepsis trial jamanetwork.com/journals/jam... #IDsky #Medsky #ICUsky #Ansky 🧪
Biomarker-Guided Antibiotic Duration for Patients With Suspected Sepsis
This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antib...
jamanetwork.com
Paul Dark@darknatter.bsky.social · last yr.Have your say - an invitation to complete this important survey to inform UK implementation sespsis patient care research in PCT-guided antibiotic duration. www.qualtrics.manchester.ac.uk/jfe/preview/... @benmorton.bsky.social @ics-updates.bsky.social @criticalcarereviews.com
Have your say - an invitation to complete this important survey to inform UK implementation sespsis patient care research in PCT-guided antibiotic duration. www.qualtrics.manchester.ac.uk/jfe/preview/... @benmorton.bsky.social @ics-updates.bsky.social @criticalcarereviews.com
Preview - Qualtrics Survey | Qualtrics Experience Management
The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.
qualtrics.manchester.ac.uk
Editor’s choice from the February 25 issue. ➡️ Camrelizumab With Chemotherapy in Patients With Early or Locally Advanced TNBC ➡️ Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis ➡️ Essential Thrombocythemia: A Review; and more. ja.ma/4hR14SI #JAMA #MedSky
www.thebottomline.org.uk/summaries/ad...
ADAPT-Sepsis: PCT or CRP Guided Antibiotic Duration
ADAPT-Sepsis: PCT or CRP-guided Antibiotic Duration for Patients with suspected Sepsis Dark et al. JAMA Dec 9 2024. doi:10.1001/jama.2024.26458 Clinical Question For critically ill adults with suspect...
thebottomline.org.uk
The third trial result for #CCR25 in Titanic Belfast in June is the UK-Rox Trial Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU Register via the QR code or on the CCR website criticalcarereviews.com/meetings/ccr25
@criticalcarereviews.com Congratulations to the newly announced PROFESSOR Rob MacSweeney. Richly deserved for a modest person who works tirelessly in support of improving care of the critically ill through world leadership and creativity for clinical research dissemination with real impact. 👏 Prof.
Chief Investigator @darknatter.bsky.social shares insights from the #ADAPTsepsistrial at #CCRdownunder @adaptsepsis @jama.com
Absolutely fantastic work from @darknatter.bsky.social and team. Looking forward to a deep dive into the paper! #ccrdownunder24
Registration for the Critical Care Reviews Meeting 2025 is now open ➡️ June 11th to 13th ➡️ Titanic Belfast, Belfast, Northern Ireland The Best Critical Care Trials in the World criticalcarereviews.com/meetings/ccr25
CCR25
Critical Care Reviews Meeting 2025, Titanic Belfast, June 11th to 13th. Featuring 12 major critical care trial results
criticalcarereviews.com
Welcome back to Manchester Critical Care Research Forum @UKCCRGroup – Tuesday 16 and Wednesday 17 September 2025 The fifteenth national forum for clinical research in critical care, emergency medicine and acute medicine Hosted by Dr Jonathan Bannard-Smith
What's your priority ? www.thelancet.com/journals/lan...
Top ten research priorities for sepsis research: UK James Lind Alliance priority setting partnership
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.1 Sepsis is a substantial global health problem due to its high incidence and associated m...
thelancet.com
Hope to see you in person or virtually for the results of ADAPT-Sepsis criticalcarereviews.com/meetings/ccr...
CCR Down Under
Critical Care Reviews Meeting Down Under - The Edge, Federation Square, Melbourne, December 10th - 11th, 2024
criticalcarereviews.com
