Also check out another paper from the Selmer Lab in the same issue of NAR @narjournal.bsky.social Adrian and Maria managed to get the first high-resolution structure of RRF and EF-G on the 70S ribosomes. This is a key step in protein synthesis. doi.org/10.1093/nar/...

Structural characterization of ribosome recycling and fusidic acid inhibition in Staphylococcus aureus

Abstract. During bacterial ribosome recycling, 70S ribosomes are split into subunits by ribosome recycling factor (RRF) and elongation factor G (EF-G). The

doi.org

Ribosomal RNA is modified at key locations. Not much happens when you remove them one by one, but what about removing them en masse around the catalytic center? The catalytic efficiency drops and the RNA forms misfolded conformations. Collaboration with the Remme Lab. @narjournal.bsky.social

23S rRNA modifications stimulate catalytic activity and prevent the formation of alternative structures

Abstract. Ribosomal RNA (rRNA) modifications cluster around the peptidyl transferase centre (PTC), the catalytic centre of the ribosome, yet their collecti

doi.org

Excited to share our preprint introducing ASHI: the Atlas of SLiM-mediated Human protein-protein Interactions. By screening 800+ domains against the human intrinsically disordered regions, we map 20,000 SLiM-mediated interactions. Many thanks to everyone involved! www.biorxiv.org/content/10.6...

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions

Short linear motifs (SLiMs) within intrinsically disordered protein regions mediate transient interactions crucial for cell physiology. However, the global interaction landscape of human SLiMs remains...

biorxiv.org

Check out our new article if you are interested in disorder-mediated protein interactions, AlphaFold-based structural modeling and variant characterization: Https://rdcu.be/fw2oz Dx.doi.org/10.1038/s41594-026-01846-z

Variant characterization in the intrinsically disordered human proteome - Nature Structural & Molecular Biology

Proteome-wide prediction and structural modeling of disordered protein interaction interfaces advance characterization of disease-associated variants in disordered protein regions.

dx.doi.org

Our MASLD paper is finally out @naturemetabolism.bsky.social @ebi.embl.org @opentargets.org ! Fantastic collaboration with Toni Vidal-Puig's group in the IMS, UCam (co-led), Papatheodorou @earlhaminst.bsky.social and other coauthors, led by Ioannis Kamzolas and Thodoris Koutsandreas. Check it out!

Open Targets@opentargets.org · last mo.

Out now in Nature Metabolism! 🖥️🧬 An Open Targets project has identified a set of plasma proteins that could be used to diagnose and monitor patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) www.nature.com/articles/s42...

My department @eth-dbiol.bsky.social at ETH Zurich is hiring for a tenured professor in mol cell bio and biochemistry (associate/full). The position is within the Institute of Biochemistry (www.bc.biol.ethz.ch) and it is fairly open within their scope of research. www.nature.com/naturecareer...

Professor of Molecular Cell Biology and Biochemistry - Zurich, Switzerland job with ETH Zurich | 12861386

The Department of Biology at ETH Zurich invites applications for the above-mentioned tenured professorship at the Institute of Biochemistry

nature.com

Excited to share our preprint introducing ASHI: the Atlas of SLiM-mediated Human protein-protein Interactions. By screening 800+ domains against the human intrinsically disordered regions, we map 20,000 SLiM-mediated interactions. Many thanks to everyone involved! www.biorxiv.org/content/10.6...

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions

Short linear motifs (SLiMs) within intrinsically disordered protein regions mediate transient interactions crucial for cell physiology. However, the global interaction landscape of human SLiMs remains...

biorxiv.org

Heidelberg University Biochemistry Center @bzh-hd.bsky.social is looking for a #professor of #biochemistry. Please spread the word‼️ www.bzh.uni-heidelberg.de

A fabulous day for Biochemistry at @uu.se celebrating the conferment of no fewer than seven PhDs in Biochemistry in one go. I’m especially proud to have served as main PhD advisor to two of these newly conferred PhDs. #Biochemistry #UppsalaUniversity #PhD #AcademicMentorship

Very much looking forward to visting #Toronto next week for the 20th anniversery symposium of the #Donnelly Centre. My postdoc stay there in 2012 helped lay the foundation for my independent lab. It will be wonderful to return and take part of the celebratation.

Just for fun, the illustration of topics we cover in the #Biochemistry research programme @uu.se

Happy to share that my #PhD student Maximilian Vieler nailed his thesis "Decoding the #ubiquitin system: charting and characterizing #motif-based interactions of #E3 ligases" today. Looking forward to the defense early June.

1/ ProPER - Our novel ligation-free proximity detection method for efficient multiplexed imaging of molecular interactions in situ. Among other things we use it to image the life cycle of RNA molecules and resolve differential kinetics of gene expression steps. New preprint: doi.org/10.64898/202...

Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪

Free and open-source images, icons, and tools for creating scientific illustrations

Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics

doi.org

📝From 2025, the Review "The intersection of viral mimicry and nuclear entry" from David Jacques et al: www.cell.com/trends/bioch...

The intersection of viral mimicry and nuclear entry

The nuclear pore complex (NPC) facilitates macromolecular exchange between the cytoplasm and nucleus; the selective nature of which is vital to proper cell functioning. Many DNA and some RNA viruses m...

cell.com

Back in Uppsala after a marvelous yearly meeting with the EU MCS DC network IDPro. It is very rewarding to see how our #doctoral candidates develop and the amazing research they are doing. Stay tuned for the output to come on #intrinsically disordered #proteins during next year.

Remember to catch out next online seminar on April 20, 3pm CEST!

PMC Protein Modules Community@pmc-modularity.bsky.social · 5mo ago

Tune in to our next seminar on April 20 at 3pm CEST! We’ll hear from Prof. Tina Perica (@glukozica.bsky.social) and Isabella Menart (@isabellamenart.bsky.social) Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity

Our new preprint on detailing the molecular mechanisms of how the carbonic anhydrase activates it's activity upon encapsulation into alpha-carboxysomes is now live. Congrats to Nikole and @guillawme.fediscience.org.ap.brid.gy !

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 5mo ago

Molecular mechanism of redox regulation of the alpha-carboxysomal carbonic anhydrase CsoSCA https://www.biorxiv.org/content/10.64898/2026.04.02.716132v1

Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.

IBEC | Institute for Bioengineering of Catalonia@ibecbarcelona.eu · 5mo ago

🔬 Investigadores de l'#IBEC creen un mapa mutacional de l’amilina que mostra com certes mutacions poden accelerar o frenar la formació d’agregats tòxics vinculats a la diabetis tipus 2.  📖 https://ibecbarcelona.eu/an-unprecedented-mutation-map-reveals-how-amylin-mutations-influence-type-2-diabetes/

Tune in to our next seminar on April 20 at 3pm CEST! We’ll hear from Prof. Tina Perica (@glukozica.bsky.social) and Isabella Menart (@isabellamenart.bsky.social) Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity

Our preprint is published in MSB! This time with the correct preprint post below! link.springer.com/article/10.1...

Integrative multi-omics defines melanoma drug response networks and ARID1A-dependent resistance mechanisms - Molecular Systems Biology

Resistance to BRAF/MAPK inhibitors is a significant challenge in melanoma treatment, driven by adaptive and acquired mechanisms allowing tumor cells to evade therapy. We explored early signaling respo...

link.springer.com

Evangelia Petsalaki@epetsalaki.bsky.social · 2y ago

We are proud to present "ARID1A-induced transcriptional reprogramming rewires signalling responses to drug treatment in melanoma" led by Charlie Barker and Sumana Sharma in collaboration with EPIC-XS Utrecht, ProtAvio, @sangerinstitute.bsky.social and UofAthens www.biorxiv.org/content/10.1...

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Fabulous Friday is when your students tell you your course was great AND you get the message "we are pleased to inform you your manuscript is in principle accepted"..

Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. www.nature.com/articles/s41...

A proteome-wide dependency map of protein interaction motifs - Nature Structural & Molecular Biology

Ambjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicte...

nature.com

Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly. www.biorxiv.org/content/10.1...

Systematic Discovery of Motif-based Interactions of the Auxiliary Domains of USP Family Deubiquitinases

The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity i...

biorxiv.org

IDPSeminas is back again TOMORROW! Talks from Lucia Strader (@luciastrader.bsky.social) and Heather Meyer! Sign up at idpseminars.com. Talks start at 1 pm EST / 7 PM CET!! Come learn about transcriptional adaptation and IDRs as environmental sensors and accuators!

US science after a year of Trump "More than 7,800 research grants terminated or frozen. Some 25,000 scientists and personnel gone from agencies that oversee research." via @nature.com Dark Age 2.0

Very much looking forward to the next PMC seminar, featring Benjamin Turk and Giorgia Massacci: www.proteinmodules.org/online-semin...

Protein Modules Community - Online seminars

Our new online seminar series explores the latest in protein modules research, featuring two talks on the second Monday of every month. Register to attend: tinyurl.com/PMCseminar2 Contact us for mo...

proteinmodules.org

PMC Protein Modules Community@pmc-modularity.bsky.social · 8mo ago

We are back on Jan 19 at 3pm CET! Our first seminar for 2026 will feature Prof. Benjamin Turk (@benturklab.bsky.social) and Dr. Giorgia Massacci. Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity

Not sure if Trump getting the Nobel Prize medal from Machado is more embarrassing for Trump, Machado, the Norwegian Nobel Committee, or the USA as a country.

This is such hard news to process. Such an amazing scientist and inspiration for so many of us. www.embl.org/news/embl-an...

In remembrance of Peer Bork  | EMBL

EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.

embl.org