The August issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Jihui Hao and colleagues showing senescent CAFs drive early-stage lymph node metastasis in PDAC via lactate-mediated metabolic-epigenetic rewiring - that and more aacrjournals.org/cancerdiscov... 👇

Now online in Cancer Discovery @aacrjournals.bsky.social: Follicular Lymphoma Transformation Is Characterized by Cytokine-associated Remodeling of Stromal and Macrophage Compartments doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Systematic Targeting of Protein Complexes with Molecular COUPLrs - by Diane Yang, Stefan Andrew Harry, Harrison Byron Chong, Neha Khandelwal, Edwin Zhang, John Iafrate, @liron1bar-peled.bsky.social, and colleagues doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Molecular and Structural Basis of Pan-Resistance to BTK Degraders and Inhibitors doi.org/10.1158/2159...

My postdoctoral work! If you are interested in degraders/PROTACs, check it out!

Abdel-Wahab Lab, MSKCC@oawlab.bsky.social · 3w ago

Excited to announce a new paper out today in Cancer Discovery @aacrjournals.bsky.social on clinical mechanisms of resistance to BTK degraders. Led by @quinnsievers.bsky.social and part of our ongoing collaboration with Meghan Thompson, Nurix Therapeutics & Justin Taylor (U. Miami):

Excited to announce a new paper out today in Cancer Discovery @aacrjournals.bsky.social on clinical mechanisms of resistance to BTK degraders. Led by @quinnsievers.bsky.social and part of our ongoing collaboration with Meghan Thompson, Nurix Therapeutics & Justin Taylor (U. Miami):

Now online in Cancer Discovery @aacrjournals.bsky.social: LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis - by Xiaowen Zhang, Mahak Singhal, @hellmutaugustin.bsky.social, and colleagues doi.org/10.1158/2159... @dkfz.bsky.social @uniheidelberg.bsky.social

Congratulations to Xiaowen Zhang for her spectacular publication in Cancer Discovery identifying a subpopulation of LPL-expressing intratumoral endothelial cells that decisively controls the anti-tumor immune response in liver metastases. See: aacrjournals.org/cancerdiscov...

Now in Cancer Discovery: two studies showing that CDK8 inhibitors act by trapping Mediator on chromatin & that cancers w/driver oncogenes acting as dosage-sensitive transcription factors (e.g. aRMS, Ewing sarcoma) are vulnerable to impairment of transcriptional regulatory complex dynamics:

In case you missed this Cancer Discovery paper in the news last week: First-in-Human Testing of a Mutant KRAS Vaccine for Pancreatic Cancer Interception in High-Risk Cohorts - by Daniel Haldar, Amanda Huff, Michael Goggins, Elizabeth Jaffee, Neeha Zaidi, and colleagues @aacrjournals.bsky.social

American Association for Cancer Research (AACR)@theaacr.bsky.social · 4w ago

A vaccine to intercept pancreatic cancer in high-risk individuals was safe and elicited specific and durable immune responses, according to research published in the AACR journal Cancer Discovery. Learn more: www.aacr.org/about-the-aa...

Robert Kruger, PhD, Editorial Director, Publications and Senior Executive Editor, Cancer Discovery is attending #AACRrarecancers26 and would love to hear about your research. Connect with him to discuss publishing opportunities in the Journals.

Hear from cancer vaccine expert and Editor-in-Chief of Cancer Immunology Research Elizabeth M. Jaffee, MD, FAACR, on the latest breakthroughs, the clinical progress, and the path toward new effective vaccine-based strategies.

American Association for Cancer Research (AACR)@theaacr.bsky.social · 4w ago

Beyond therapy, research on vaccines for pancreatic cancer is exploring their application for cancer interception. Learn more about this and other recent advances on the #AACRBlog:

Now in Cancer Discovery @aacrjournals.bsky.social: Impact of Vitamin D on the CRC Immune Microenvironment: A Randomized Clinical Trial of Preoperative Vitamin D Supplementation in Patients w/Stage I-III CRC - by Andressa Dias Costa, Jonathan Nowak, Kimmie Ng, et al. doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Germline CDK12 Variants in Aggressive Prostate Cancer - by Sofie Tolmeijer, Colin Pritchard, Alexander Wyatt, and colleagues doi.org/10.1158/2159...

The July issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Jimin Min, Lisa Schweizer, Anirban Maitra, Andreas Mund et al. using AI-powered deep visual proteomics to reveal molecular transitions in pancreatic cancer - more here: aacrjournals.org/cancerdiscov...

AACR is deeply concerned that proposed OMB regulations would disrupt the process for awarding federal research grants, severely weakening a program that has supported American medical innovation for decades. Learn more: buff.ly/GLOGlW8 #UnitedByCancerResearch

buff.ly

It's been a pleasure to work with Dr. Vander Heiden so far and I look forward to the next era of Cancer Discovery under his leadership! Luis Diaz, Tali Lev, Lisa Situ, Robert Kruger, and I joined him for our first team meeting at #AACR26 (Michele Hartsough and I-Mei Siu were holding down the fort)

American Association for Cancer Research (AACR)@theaacr.bsky.social · last mo.

AACR is pleased to announce that Matthew Vander Heiden, MD, PhD, FAACR, has been appointed editor-in-chief of the AACR journal Cancer Discovery. He joins Luis A. Diaz, Jr., MD, FAACR, in guiding this premier publication. Learn more: www.aacr.org/about-the-aa... #AACRFellows @aacrjournals.bsky.social

Now in Cancer Discovery @aacrjournals.bsky.social: Tumor Microbial Burden Drives Immune Responses via Regulation of Interferon Signaling - by Haoyue Liu, Jeong-Hoon Jang, Fuduan Peng, Hajar Rajaei, @linghua-wang.bsky.social , Luis Diaz, Florencia McAllister, and colleagues doi.org/10.1158/2159...

Harmony Turk, PhD, Executive Editor of Cancer Research, is attending the 2026 @metastasisresearch.bsky.social Society Biennial Congress. If you have a question about the journals or are interested in discussing your research, reach out to her at harmony.turk@aacr.org. #MRS2026

Now in Cancer Discovery @aacrjournals.bsky.social: Spatial Multiomics Implicate Tpex-B cell Interaction in Tertiary Lymphoid Structures after Neoadjuvant Therapy - by Jingying Huang, Yahui Chen, Peng Deng, Qian Kong, Konglan Lin, Ruijun Tian, Yiwen Lu, Shicheng Su, et al. doi.org/10.1158/2159...

It's another KRAS day at Cancer Discovery @aacrjournals.bsky.social! Three papers now online about mutant KRAS alleles, rewiring that occurs after allele-specific KRAS inhibition, and potential combination approaches 👇

Now in Cancer Discovery @aacrjournals.bsky.social: Deconvolving SARS-CoV-2 mRNA Vaccine Impact on Immunotherapy-related Survival - by Justin Jee, @sawyerslabmskcc.bsky.social, Nikolaus Schultz, et al. doi.org/10.1158/2159... @mskcancercenter.bsky.social

Now online in Cancer Discovery @aacrjournals.bsky.social: The Landscape of Prostate Tumor Methylation - by Jaron Arbet, Takafumi Yamaguchi, Paul Boutros, and colleagues doi.org/10.1158/2159...

The June issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Yan Zhang, Songhua Wang, Weiwei Ma, Yuan Wang, et al. showing a role for tumor microtube expansion & neural synaptic pruning in GBM - Read that & more: aacrjournals.org/cancerdiscov...

Joan Massague giving the keynote at the EMBO Workshop on the Many Faces of Cancer Evolution - read his recent piece in Cancer Discovery @aacrjournals.bsky.social calling for an organ-informed precision oncology framework integrating site-imposed metastatic programs aacrjournals.org/cancerdiscov...

Couldn’t be happier to return to Rimini for the 3rd edition of the EMBO Workshop on the Many Faces of Cancer Evolution! Thanks @magnanilab.bsky.social @ciriellolab.bsky.social Céline Vallot, and Samra Turajlic for the invitation and congrats on another amazing meeting!

Now online in Cancer Discovery @aacrjournals.bsky.social: Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer - by Ahmed Elhossiny, @fertiglab.bsky.social, Eileen Carpenter, Timothy Frankel, Marina Pasca di Magliano, et al. doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Senescent-like Neutrophils Shape Angiogenic Immunosuppressive Niches in CRC Liver Metastasis - by Zhihang Chen, Xiaoxue Ren, Yifan Zhang, Youmei Kang, Ye Yang, Xiaoxing Li, Jianting Long, Lixia Xu, Ming Kuang, et al. doi.org/10.1158/2159...

Now online in Cancer Discovery AACR Journals: Mismatch Repair-Proficient Colorectal Cancer Can Evade Immune Surveillance through an Intrinsic Suppressive Program - by Chiara Cattaneo, Sharon Scardellato, @bardellilab.bsky.social et al. doi.org/10.1158/2159... IFOM

Now online in Cancer Discovery AACR Journals: A Spatial Atlas of Muscle-Invasive Bladder Cancer Reveals Lineage-Specific Vulnerabilities and Immune Architecture - by Kai Yu, Jianfeng Chen, Jianjun Gao, Linghua Wang, MD, PhD, et al. doi.org/10.1158/2159... @mdanderson.bsky.social