Delighted to be a small part of this beautiful new study from @mariakoufaki.bsky.social and @santiagozelenay.bsky.social, identifying a #DendriticCell phenotype and activation state that is critical for anti- #tumour #immunity 🧪 #ImmunSky - congratulations Maria and Santiago!

Immunity@cp-immunity.bsky.social · 4d ago

Online now: CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity

You've got just a few days left to submit your proposal to join us as a new Group Leader 📅 Applications close 2nd November Package includes: 🪙Multi-year funding 🧪Core Facility Access 🥼 #Postdoc & #PhD positions 🤝Mentorship Visit our website to apply: www.cruk.manchester.ac.uk/career/new-g...

Exciting #postdoc opportunity to join @turajliclab.bsky.social here in #Manchester (with visiting scientist status @crick.ac.uk) to use novel tools to investigate #aneuploidy in #KidneyCancer For full details of the position, including how to apply, visit: www.cruk.manchester.ac.uk/career/mi-25...

Just 3 days left to apply for a #postdoc position with @clausjorgensen.bsky.social and the Systems Oncology group 🥼Study a novel therapeutic target in #PancreaticCancer relating to the #TumourMicroenvironment For full details & to apply please visit: www.cruk.manchester.ac.uk/career/mi-25...

Now online in Cancer Discovery @aacrjournals.bsky.social: Glucocorticoids Unleash Immune-dependent Melanoma Control through Inhibition of the GARP/TGF β Axis - by Charles Earnshaw, @santiagozelenay.bsky.social, and colleagues doi.org/10.1158/2159... @cruk-mi.bsky.social

We have exciting research projects led by group leaders including @jloke1.bsky.social, @giampazolias.bsky.social, @turajliclab.bsky.social, @sylvaindelaunay.bsky.social and @santiagozelenay.bsky.social See full details of all #PhD opportunities here: www.cruk.manchester.ac.uk/phd-student-...

PhD Student Recruitment 2026 - OPEN | CRUK Manchester Institute

We are pleased to announce seven exciting postgraduate opportunities within the Cancer Research UK Manchester Institute for new PhD Students to start in 2026

cruk.manchester.ac.uk

Exciting new research from our Cancer Inflammation and Immunity Group led by @santiagozelenay.bsky.social on the counterintuitive effects of steroids to enhance responses to immunotherapy in #melanoma Visit our website for more on this paper published today in Cancer Discovery

Glucocorticoids Unleash Immune-dependent Melanoma Control Through Inhibition Of The GARP/TGF β Axis | Cancer Research UK Manchester Institute

This study uncovers a surprising role for GCs in triggering CD8+ T cell–dependent tumour control through downregulation of GARP and thus TGF β signalling.

cruk.manchester.ac.uk

We are recruiting! 🥼 Scientific Officer to work with @drwilliamhill.bsky.social 💻 Computational Immunologist in the lab of @santiagozelenay.bsky.social 📝 Executive Assistant to our new Institute Director Prof Samra Turajlić @turajliclab.bsky.social Details at: www.cruk.manchester.ac.uk/careers/

We are delighted to announce, along with Cancer Research UK (@cancerresearchuk.org), The University of Manchester (@manchester.ac.uk) and The Christie NHS Foundation Trust, the appointment of Professor Samra Turajlić as our new Director! ⭐ Full story here: www.cruk.manchester.ac.uk/news/profess...

We are recruiting a #postdoctoral researcher for our Cancer Inflammation and Immunity group headed by @santiagozelenay.bsky.social For all the project details, research background, information about the position and the Institute, please visit: www.cruk.manchester.ac.uk/career/mi-25...

And learn more about the role and how to apply here: www.cruk.manchester.ac.uk/career/mi-25... Please share with anyone who might be interested!

Santiago Zelenay@santiagozelenay.bsky.social · last yr.

Interested in investigating the principles that regulate the establishment of tumour environments that promote or inhibit the anti-tumour function of the immune system? Our group is currently recruiting a postdoctoral fellow. Learn more about our research 👇 www.cruk.manchester.ac.uk/research-gro...

Interested in investigating the principles that regulate the establishment of tumour environments that promote or inhibit the anti-tumour function of the immune system? Our group is currently recruiting a postdoctoral fellow. Learn more about our research 👇 www.cruk.manchester.ac.uk/research-gro...

I am excited to share our study showing how the immune system strikes a delicate balance between tolerating food and defending against helminth infections. www.science.org/doi/10.1126/....

Identification of antigen-presenting cell–T cell interactions driving immune responses to food

The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...

science.org

Interesting work, it's becoming clear that @santiagozelenay.bsky.social's 2015 work on the COX-PGE axis' role in tumor immune evasion is robust (and also that we really need to focus on type I IFN in anti-tumor immunity). #Immunology #Immunotherapy #Immunosky

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

Cyclooxygenase-driven prostaglandin E2, produced by a variety of tumors, drives malignant growth through successful evasion of type I interferon and/or T-cell-dependent tumor elimination. A remarkable synergy between cyclooxygenase inhibitors and checkpoint blockade immunotherapy results in tumor eradication.

cell.com

Anna Obenauf@obenaufa.bsky.social · 2y ago

Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz

But because, as many people like to complain, nothing in immunology is simple, Ifn gamma also has an important role to play www.cell.com/immunity/ful...

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade

Inflammation can fuel or suppress cancer. Bonavita et al. identify NK cells as primary orchestrators of T cell inflammation in murine models and devise an inflammatory signature that predicts patient survival and response to immunotherapy in multiple malignancies.

cell.com

⏰ Final call! 🧑‍🔬 Last week to apply for this fantastic opportunity to work with the exceptional @giampazolias.bsky.social at @cruk-mi.bsky.social. #TeamManchester To apply (deadline 1 Dec 2024): www.cruk.manchester.ac.uk/recruitment/...

Jon Lim, FRCP PhD@drjonlim.bsky.social · 2y ago

🧑‍🔬 Interested in #CancerImmunology? Looking for #postdoc position? Excellent opportunity to join us in Manchester to work with my close friend & collaborator @giampazolias.bsky.social - a superb scientist & group leader 💫! We have many things planned, including #TranslationalResearch. More info 👇

Are so-called 'M2-like' CD206+ macrophages immunosuppressive? On the contrary, we find that they are critical for T cell mediated anti-tumor immunity. Arja Ray drove this study with help from Ken Hu, Kelly Kersten, Alexis Combes and others www.biorxiv.org/content/10.1...

Critical role of CD206+ macrophages in organizing anti-tumor immunity

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

We’ve renewed funding for our Lung Cancer Centre of Excellence for the next 5 years! With up to £4m support from our partner ScottishPower, researchers will continue to find new ways to beat #LungCancer 👇 @cruk-mi.bsky.social @thecrick.bsky.social news.cancerresearchuk.org/2024/11/20/4...

£4m funding renewal for lung cancer research in Manchester and London - Cancer Research UK - Cancer News

The Lung Cancer Centre of Excellence will continue its groundbreaking research with up to £4m of funding support from ScottishPower.

news.cancerresearchuk.org

Enjoying an izakaya with Santiago Zelenay in Kyoto, a Demengeot lab reunion.

The final event of the CCII-Kyoto inaugural symposium: a workshop for students/postdocs on #immunity #Metabolism #inflammation & #ageing with Hongbo Chi, Santiago Zelenay & Osamu Takeuchi #Immunology www.ccii.med.kyoto-u.ac.jp/en/

💥Exciting #ERCResearch funded postdoc opportunities in my lab at @cruk-mi.bsky.social to study #NutrientHostMicrobiome interactions in #CancerImmunity in mice and humans. #CancerImmunology#MucosalImmunology#Microbiome ⏰Deadline: 1 December 2024 Apply👇 www.cruk.manchester.ac.uk/recruitment/... ⏩RT